Local Structure of Ge／SI（100） Self—Assembled Quantum Dots

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Transiting circumbinary planets Kepler-34 b and Kepler-35 b

Most Sun-like stars in the Galaxy reside in gravitationally bound pairs of stars (binaries). Although long anticipated, the existence of a 'circumbinary planet' orbiting such a pair of normal stars was not definitively established until the discovery of the planet transiting (that is, passing in front of) Kepler-16. Questions remained, however, about the prevalence of circumbinary planets and their range of orbital and physical properties. Here we report two additional transiting circumbinary planets: Kepler-34 (AB)b and Kepler-35 (AB)b, referred to here as Kepler-34 b and Kepler-35 b, respectively. Each is a low-density gas-giant planet on an orbit closely aligned with that of its parent stars. Kepler-34 b orbits two Sun-like stars every 289?days, whereas Kepler-35 b orbits a pair of smaller stars (89% and 81% of the Sun's mass) every 131?days. The planets experience large multi-periodic variations in incident stellar radiation arising from the orbital motion of the stars. The observed rate of circumbinary planets in our sample implies that more than ～1% of close binary stars have giant planets in nearly coplanar orbits, yielding a Galactic population of at least several million.     

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

The newly recognized ataxia-ocular apraxia 1 (AOA1; MIM 208920) is the most frequent cause of autosomal recessive ataxia in Japan and is second only to Friedreich ataxia in Portugal. It shares several neurological features with ataxia-telangiectasia, including early onset ataxia, oculomotor apraxia and cerebellar atrophy, but does not share its extraneurological features (immune deficiency, chromosomal instability and hypersensitivity to X-rays). AOA1 is also characterized by axonal motor neuropathy and the later decrease of serum albumin levels and elevation of total cholesterol. We have identified the gene causing AOA1 and the major Portuguese and Japanese mutations. This gene encodes a new, ubiquitously expressed protein that we named aprataxin. This protein is composed of three domains that share distant homology with the amino-terminal domain of polynucleotide kinase 3'- phosphatase (PNKP), with histidine-triad (HIT) proteins and with DNA-binding C2H2 zinc-finger proteins, respectively. PNKP is involved in DNA single-strand break repair (SSBR) following exposure to ionizing radiation and reactive oxygen species. Fragile-HIT proteins (FHIT) cleave diadenosine tetraphosphate, which is potentially produced during activation of the SSBR complex. The results suggest that aprataxin is a nuclear protein with a role in DNA repair reminiscent of the function of the protein defective in ataxia-telangiectasia, but that would cause a phenotype restricted to neurological signs when mutant.     

istic Conception is

一、网络防火墙技术网络防火墙技术作为内部网络与外部网络之间的第一道安全屏障,是最先受到人们重视的网络安全技术,就其产品的主流趋势而言,大多数代理服务器(也称应用网关)集成了包滤技术。我们应该在哪些地方部署防火墙呢?首先,安装防火墙的位置应该是公司内部网络与外部In     

Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome

Deficient activities of multiple steroidogenic enzymes have been reported without and with Antley-Bixler syndrome (ABS), but mutations of corresponding cytochrome P450 enzymes have not been found. We identified mutations in POR, encoding P450 oxidoreductase, the obligate electron donor for these enzymes, in a woman with amenorrhea and three children with ABS, even though knock-out of POR is embryonically lethal in mice. Mutations of POR also affect drug-metabolizing P450 enzymes, explaining the association of ABS with maternal fluconazole ingestion.     

辽河西部凹陷地层水特征及其成因分析

辽河西部凹陷886个水样分析化验测试数据表明,地层水型主要为低矿化度的NaHCO₃水型,94.3%的地层水化学组分为HCO₃^－、Cl^－、Na⁺,NaHCO₃和NaCl是其主要的表现形式     

地层抬升剥蚀对油气成藏的促进作用

地层抬升剥蚀过程对于油气成藏的影响不仅表现为破坏性,还有建设性作用。研究认为地层抬升剥蚀过程中温度降低、砂体回弹及不均衡剥蚀造成的区域性水流等因素形成的异常低压,为油     

裂缝伤害对套管射孔压裂井产能影响分析

在套管射孔压裂井中,存在影响井生产动态的裂缝伤害:瓶颈裂缝和压裂液滤失形成的滤失带伤害。运用分析方法研究了上述伤害对井产能的影响。分析结果表明两种类型的裂缝伤害都会降低压裂井产能,与滤失带伤害相比,瓶颈裂缝大幅度地降低了井产能,最大降幅达7倍。虽然压裂液滤失对井产能的影响没有瓶颈裂缝那么大,但也降低多一半。在实际施工中,应采用各种措施消除瓶颈裂缝和减小压裂液滤失。     

一种混合退化系统剩余寿命预测方法

针对传统的预测方法不能同时考虑线性和非线性退化问题,提出了一种基于维纳过程的带随机参数和确定参数的混合退化模型.基于首达时间(FHT)的概念给出了剩余寿命(RUL)的解析渐进显式形式,模型中随机参数通过Kalman滤波技术实时更新,确定参数采用极大似然估计进行估计.最后,采用陀螺仪实验数据验证了该方法的有效性.