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991.
CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members 总被引:1,自引:0,他引:1
Trompouki E Hatzivassiliou E Tsichritzis T Farmer H Ashworth A Mosialos G 《Nature》2003,424(6950):793-796
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A large number of high-accuracy vector measurements of the Earth's magnetic field have recently become available from the satellite Oersted, complementing previous vector data from the satellite Magsat, which operated in 1979/80. These data can be used to infer the morphology of the magnetic field at the surface of the fluid core, approximately 2,900 km below the Earth's surface. Here I apply a new methodology to these data to calculate maps of the magnetic field at the core surface which show intense flux spots in equatorial regions. The intensity of these features is unusually large--some have intensities comparable to high-latitude flux patches near the poles, previously identified as the major component of the dynamo field. The tendency for pairing of some of these spots to the north and south of the geographical equator suggests they might be associated with the tops of equatorially symmetric columnar structures in the fluid, or their antisymmetric equivalents. The drift of the equatorial features may represent material flow or could represent wave motion; discrimination of these two effects based on future data could provide new information on the strength of the hidden toroidal magnetic field of the Earth. 相似文献
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Amanullah A Azam N Balliet A Hollander C Hoffman B Fornace A Liebermann D 《Nature》2003,424(6950):741; discussion 742
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Reeves WH Skryabin DV Biancalana F Knight JC Russell PS Omenetto FG Efimov A Taylor AJ 《Nature》2003,424(6948):511-515
Photonic crystal fibres (PCFs) offer greatly enhanced design freedom compared to standard optical fibres. For example, they allow precise control of the chromatic dispersion (CD) profile--the frequency dependence of propagation speed--over a broad wavelength range. This permits studies of nonlinear pulse propagation in previously inaccessible parameter regimes. Here we report on spectral broadening of 100-fs pulses in PCFs with anomalously flat CD profiles. Maps of the spectral and spatio-temporal behaviour as a function of power show that dramatic conversion (to both longer and shorter wavelengths) can occur in remarkably short lengths of fibre, depending on the magnitude and shape of the CD profile. Because the PCFs used are single-mode at all wavelengths, the light always emerges in a fundamental guided mode. Excellent agreement is obtained between the experimental results and numerical solutions of the nonlinear wave equation, indicating that the underlying processes can be reliably modelled. These results show how, through appropriate choice of CD, nonlinearities can be efficiently harnessed to generate laser light at new wavelengths. 相似文献
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Nishimoto S Kawane K Watanabe-Fukunaga R Fukuyama H Ohsawa Y Uchiyama Y Hashida N Ohguro N Tano Y Morimoto T Fukuda Y Nagata S 《Nature》2003,424(6952):1071-1074
The eye lens is composed of fibre cells, which develop from the epithelial cells on the anterior surface of the lens. Differentiation into a lens fibre cell is accompanied by changes in cell shape, the expression of crystallins and the degradation of cellular organelles. The loss of organelles is believed to ensure the transparency of the lens, but the molecular mechanism behind this process is not known. Here we show that DLAD ('DNase II-like acid DNase', also called DNase IIbeta) is expressed in human and murine lens cells, and that mice deficient in the DLAD gene are incapable of degrading DNA during lens cell differentiation--the undigested DNA accumulates in the fibre cells. The DLAD-/- mice develop cataracts of the nucleus lentis, and their response to light on electroretinograms is severely reduced. These results indicate that DLAD is responsible for the degradation of nuclear DNA during lens cell differentiation, and that if DNA is left undigested in the lens, it causes cataracts of the nucleus lentis, blocking the light path. 相似文献
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