利用Fabry-Perot谐振腔和介质谐振天线实现约瑟夫森结阵列的自辐射

本文提出了一种利用Fabry-Perot谐振腔和介质谐振天线,同时集成偶极天线阵实现约瑟夫森结阵列自辐射的方法.在介质基片上制作集成偶极天线阵的双晶约瑟夫森结阵列,并将其嵌入到Fabry-Perot谐振腔内.将基片作为一介质谐振天线,使其与Fabry-Perot谐振腔谐振在同一频率下,从而通过高频电磁耦合机制实现结之间以及结与外部微波电路之间的耦合.文中分别进行了数值仿真和实验研究.对一个包含166个双晶约瑟夫森结的结阵列进行了液氮温度时的测试,在片外（off-chip）检测到了75.2GHz,10pW的辐射信号,与仿真结果吻合.该方法为基于约瑟夫森效应的太赫兹（THz）源提供了一种可能.     

一种潜在语义索引差异模型

通过对全局模型和局部模型的分析,提出一种新的潜在语义索引差异模型,能将类别信息反应在词项中、以医学网页为实验对象,将网页中的文本抽取出来并分别用全局模型和差异模型表示,采用SVD和SLSI降维,利用SVM算法进行分类并计算分类正确率和F1指标．实验发现：采用差异模型表示时,2种降维技术下分类正确率和F1指标较全局模型都有明显提高;同时采用差异模型和SLSI算法并不能对分类结果有更大改善     

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Cell growth and proliferation require coordinated ribosomal biogenesis and translation. Eukaryotic initiation factors (eIFs) control translation at the rate-limiting step of initiation. So far, only two eIFs connect extracellular stimuli to global translation rates: eIF4E acts in the eIF4F complex and regulates binding of capped messenger RNA to 40S subunits, downstream of growth factors, and eIF2 controls loading of the ternary complex on the 40S subunit and is inhibited on stress stimuli. No eIFs have been found to link extracellular stimuli to the activity of the large 60S ribosomal subunit. eIF6 binds 60S ribosomes precluding ribosome joining in vitro. However, studies in yeasts showed that eIF6 is required for ribosome biogenesis rather than translation. Here we show that mammalian eIF6 is required for efficient initiation of translation, in vivo. eIF6 null embryos are lethal at preimplantation. Heterozygous mice have 50% reduction of eIF6 levels in all tissues, and show reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression. eIF6(+/-) cells retain sufficient nucleolar eIF6 and normal ribosome biogenesis. The liver of eIF6(+/-) mice displays an increase of 80S in polysomal profiles, indicating a defect in initiation of translation. Consistently, isolated hepatocytes have impaired insulin-stimulated translation. Heterozygous mouse embryonic fibroblasts recapitulate the organism phenotype and have normal ribosome biogenesis, reduced insulin-stimulated translation, and delayed G1/S phase progression. Furthermore, eIF6(+/-) cells are resistant to oncogene-induced transformation. Thus, eIF6 is the first eIF associated with the large 60S subunit that regulates translation in response to extracellular signals.     

具有抗艾滋病毒活性的多肽T22([T5,12yr,L7yr]-PolyphemusinⅡ)骨架构象模拟

用势能平滑搜索方法,在平滑修饰的势能面上对具有抗艾滋病毒HIV－1活性的肽T22（[Tyr^5,12,Tyr^7]-PolyphemusinⅡ）骨架结构进行了全程搜索,得到了该分子骨加结构在修饰势能面上的分子构象全集。用多构象优化方法,选择较适用于肽OPLS力场,采用GB／SA水溶剂模型,优化上述构象集,得到T22骨架结构在水溶液中优势构象集。结果表明势能平滑搜索与多构象优化相结合的构象分析方法是解决含有环结构的柔性分子构象分析中多重最小问题的有效方法。     

利用人工智能神经网络和DEM数据进行植被变化探测

适时精确的探测土地利用和覆盖变化是研究其起因、过程和效应的基础.本研究利用人工智能神经网络对两景不同时期的影像(2003和2004年)进行一次性变化探测.并且输入层中增加了DEM和坡度两个额外"波段".在选取训练样区的过程中,共选取了82个亚类型,其中36个为植被变化亚类型,46个为无变化植被亚类型.NDVI差值法被用于探测变化和无变化的区域,该方法为获取精确的和足够的植被变化类型训练样区提供有效的参考.研究结果显示利用人工智能神经网络探测变化技术所产生的植被变化图,其精度明显高于分类后比较法所产生的植被变化图精度.此外将DEM和坡度作为额外波段结合两景影像得的8个主成分作为输入层,能够有效的提高人工智能神经网络进行山区植被变化探测精度.同时在选取训练样区的过程中,将各不同的变化和无变化的植被类型根据其不同的光谱特征分成不同的亚类型进行取样,对提高人工智能神经网络进行山区植被变化探测精度有着非常重要的促进作用,此处理可以降低山区影像的地形效应.     

砂类盐渍土起胀含盐量的试验探讨

目前对盐渍土起胀含盐量的判定多是通过不同学者拟合的盐胀率计算公式反推算求得的,其结果莫衷一是,因此需采用试验方法予以明确.试验选择8种不同孔隙率(级配)的土样,在单次降温条件下观测其是否发生盐胀变形.通过试验发现:砂土起胀含盐量随着孔隙率增长呈现出先长后降的规律,这一规律在不同含水量条件下都有体现.这一现象与盐分在土颗粒间的结晶位置发生改变有关,孔隙率较小时,土壤饱和度较高,盐分多在孔隙内部结晶析出;当孔隙率增加后,土饱和度降低,盐分则转移到水膜较厚的颗粒接触点位置析出,因此启动盐胀所需盐分减少,起胀含盐量下降.     

钢筋受压黏结滑移模型

为研究钢筋的受压黏结滑移关系,采用分辨率较高的激光位移计,对一批短锚长试件进行系列推出试验研究,得到精确度较高的黏结滑移值及完整的试验黏结滑移关系曲线,描述钢筋在混凝土中的受压黏结滑移破坏全过程:弹性阶段、局部滑移阶段、滑移上升段、滑移下降段和残余段.在对试验得到的较短锚长试件推出试验结果分析的基础上,经统计回归和分析,提出钢筋的受压黏结滑移曲线模型,并与试验结果进行对比.     

'Designer atoms' for quantum metrology

Entanglement is recognized as a key resource for quantum computation and quantum cryptography. For quantum metrology, the use of entangled states has been discussed and demonstrated as a means of improving the signal-to-noise ratio. In addition, entangled states have been used in experiments for efficient quantum state detection and for the measurement of scattering lengths. In quantum information processing, manipulation of individual quantum bits allows for the tailored design of specific states that are insensitive to the detrimental influences of an environment. Such 'decoherence-free subspaces' (ref. 10) protect quantum information and yield significantly enhanced coherence times. Here we use a decoherence-free subspace with specifically designed entangled states to demonstrate precision spectroscopy of a pair of trapped Ca+ ions; we obtain the electric quadrupole moment, which is of use for frequency standard applications. We find that entangled states are not only useful for enhancing the signal-to-noise ratio in frequency measurements--a suitably designed pair of atoms also allows clock measurements in the presence of strong technical noise. Our technique makes explicit use of non-locality as an entanglement property and provides an approach for 'designed' quantum metrology.     

The medaka draft genome and insights into vertebrate genome evolution

Teleosts comprise more than half of all vertebrate species and have adapted to a variety of marine and freshwater habitats. Their genome evolution and diversification are important subjects for the understanding of vertebrate evolution. Although draft genome sequences of two pufferfishes have been published, analysis of more fish genomes is desirable. Here we report a high-quality draft genome sequence of a small egg-laying freshwater teleost, medaka (Oryzias latipes). Medaka is native to East Asia and an excellent model system for a wide range of biology, including ecotoxicology, carcinogenesis, sex determination and developmental genetics. In the assembled medaka genome (700 megabases), which is less than half of the zebrafish genome, we predicted 20,141 genes, including approximately 2,900 new genes, using 5'-end serial analysis of gene expression tag information. We found single nucleotide polymorphisms (SNPs) at an average rate of 3.42% between the two inbred strains derived from two regional populations; this is the highest SNP rate seen in any vertebrate species. Analyses based on the dense SNP information show a strict genetic separation of 4 million years (Myr) between the two populations, and suggest that differential selective pressures acted on specific gene categories. Four-way comparisons with the human, pufferfish (Tetraodon), zebrafish and medaka genomes revealed that eight major interchromosomal rearrangements took place in a remarkably short period of approximately 50 Myr after the whole-genome duplication event in the teleost ancestor and afterwards, intriguingly, the medaka genome preserved its ancestral karyotype for more than 300 Myr.