The Fundamental Definitions in Radar Measurement Principle and Theory of Space and Time

Fundamental definitions of distance and velocity in radar measurement principle are examined and revised from strict theoretical point of view. Synchronization scheme - for clocks in uniform, translatory relative motion is introduced as theoretical foundation for GPS and GLONASS type navigation and positioning technology. Traditional definitions of two-way radar measurement, based on arithmetic mean vlaue concept, turn out to be special cases of revised definitions for one-way radar measurement, based on geometric mean concept, derived from synchronization of moving clocks in accordance with the principle of relativity. The essential physical meaning of Lorentz transformation is interpreted in terms of radar measured parameters. Invariance or absoluteness of four dimensional interval turns out to be invariance or absoluteness of geometric mean time interval. The Lorentz factor turns out to be ratio of geometric mean and arithmetic mean time intervals in terms of radar measured parameters. Theoretical re     

An effective absorbing boundary algorithm for acoustical wave propagator

In this paper,Berenger's perfectly matched layer(PML)absorbing boundary condition for electromagnetic waves is introduced as the truncation area of the computational domain to absorb one-dimensional acoustic wave for the scheme of acoustical wave propagator(AWP).To guarantee the efficiency of the AWP algorithm,a regulated propagator matrix is derived in the PML medium.Numerical simulations of a Gaussian wave packet propagating in one-dimensional duct are carried out to illustrate the efficiency of the combination of PML and AWP.Compared with the traditional smoothing truncation windows technique of AWP,this scheme shows high computational accuracy in absorbing acoustic wave when the acoustical wave arrives at the computational edges.Optimal coefficients of the PML configurations are also discussed.     

Use of human tissue to assess the oncogenic activity of melanoma-associated mutations

Multiple genetic alterations occur in melanoma, a lethal skin malignancy of increasing incidence. These include mutations that activate Ras and two of its effector cascades, Raf and phosphoinositide 3-kinase (PI3K). Induction of Ras and Raf can be caused by active N-Ras and B-Raf mutants as well as by gene amplification. Activation of PI3K pathway components occurs by PTEN loss and by AKT3 amplification. Melanomas also commonly show impairment of the p16(INK4A)-CDK4-Rb and ARF-HDM2-p53 tumor suppressor pathways. CDKN2A mutations can produce p16(INK4A) and ARF protein loss. Rb bypass can also occur through activating CDK4 mutations as well as by CDK4 amplification. In addition to ARF deletion, p53 pathway disruption can result from dominant negative TP53 mutations. TERT amplification also occurs in melanoma. The extent to which these mutations can induce human melanocytic neoplasia is unknown. Here we characterize pathways sufficient to generate human melanocytic neoplasia and show that genetically altered human tissue facilitates functional analysis of mutations observed in human tumors.     

Multiple volcanic episodes of flood basalts caused by thermochemical mantle plumes

The hypothesis that a single mushroom-like mantle plume head can generate a large igneous province within a few million years has been widely accepted. The Siberian Traps at the Permian-Triassic boundary and the Deccan Traps at the Cretaceous-Tertiary boundary were probably erupted within one million years. These large eruptions have been linked to mass extinctions. But recent geochronological data reveal more than one pulse of major eruptions with diverse magma flux within several flood basalts extending over tens of million years. This observation indicates that the processes leading to large igneous provinces are more complicated than the purely thermal, single-stage plume model suggests. Here we present numerical experiments to demonstrate that the entrainment of a dense eclogite-derived material at the base of the mantle by thermal plumes can develop secondary instabilities due to the interaction between thermal and compositional buoyancy forces. The characteristic timescales of the development of the secondary instabilities and the variation of the plume strength are compatible with the observations. Such a process may contribute to multiple episodes of large igneous provinces.     

A rice quantitative trait locus for salt tolerance encodes a sodium transporter

Many important agronomic traits in crop plants, including stress tolerance, are complex traits controlled by quantitative trait loci (QTLs). Isolation of these QTLs holds great promise to improve world agriculture but is a challenging task. We previously mapped a rice QTL, SKC1, that maintained K(+) homeostasis in the salt-tolerant variety under salt stress, consistent with the earlier finding that K(+) homeostasis is important in salt tolerance. To understand the molecular basis of this QTL, we isolated the SKC1 gene by map-based cloning and found that it encoded a member of HKT-type transporters. SKC1 is preferentially expressed in the parenchyma cells surrounding the xylem vessels. Voltage-clamp analysis showed that SKC1 protein functions as a Na(+)-selective transporter. Physiological analysis suggested that SKC1 is involved in regulating K(+)/Na(+) homeostasis under salt stress, providing a potential tool for improving salt tolerance in crops.     

Ultrasonic communication in frogs

Among vertebrates, only microchiropteran bats, cetaceans and some rodents are known to produce and detect ultrasounds (frequencies greater than 20 kHz) for the purpose of communication and/or echolocation, suggesting that this capacity might be restricted to mammals. Amphibians, reptiles and most birds generally have limited hearing capacity, with the ability to detect and produce sounds below approximately 12 kHz. Here we report evidence of ultrasonic communication in an amphibian, the concave-eared torrent frog (Amolops tormotus) from Huangshan Hot Springs, China. Males of A. tormotus produce diverse bird-like melodic calls with pronounced frequency modulations that often contain spectral energy in the ultrasonic range. To determine whether A. tormotus communicates using ultrasound to avoid masking by the wideband background noise of local fast-flowing streams, or whether the ultrasound is simply a by-product of the sound-production mechanism, we conducted acoustic playback experiments in the frogs' natural habitat. We found that the audible as well as the ultrasonic components of an A. tormotus call can evoke male vocal responses. Electrophysiological recordings from the auditory midbrain confirmed the ultrasonic hearing capacity of these frogs and that of a sympatric species facing similar environmental constraints. This extraordinary upward extension into the ultrasonic range of both the harmonic content of the advertisement calls and the frog's hearing sensitivity is likely to have co-evolved in response to the intense, predominantly low-frequency ambient noise from local streams. Because amphibians are a distinct evolutionary lineage from microchiropterans and cetaceans (which have evolved ultrasonic hearing to minimize congestion in the frequency bands used for sound communication and to increase hunting efficacy in darkness), ultrasonic perception in these animals represents a new example of independent evolution.     

The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design

The worldwide spread of H5N1 avian influenza has raised concerns that this virus might acquire the ability to pass readily among humans and cause a pandemic. Two anti-influenza drugs currently being used to treat infected patients are oseltamivir (Tamiflu) and zanamivir (Relenza), both of which target the neuraminidase enzyme of the virus. Reports of the emergence of drug resistance make the development of new anti-influenza molecules a priority. Neuraminidases from influenza type A viruses form two genetically distinct groups: group-1 contains the N1 neuraminidase of the H5N1 avian virus and group-2 contains the N2 and N9 enzymes used for the structure-based design of current drugs. Here we show by X-ray crystallography that these two groups are structurally distinct. Group-1 neuraminidases contain a cavity adjacent to their active sites that closes on ligand binding. Our analysis suggests that it may be possible to exploit the size and location of the group-1 cavity to develop new anti-influenza drugs.     

Corneal avascularity is due to soluble VEGF receptor-1

Corneal avascularity-the absence of blood vessels in the cornea-is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many disorders. But the molecular underpinnings of the avascular phenotype have until now remained obscure and are all the more remarkable given the presence in the cornea of vascular endothelial growth factor (VEGF)-A, a potent stimulator of angiogenesis, and the proximity of the cornea to vascularized tissues. Here we show that the cornea expresses soluble VEGF receptor-1 (sVEGFR-1; also known as sflt-1) and that suppression of this endogenous VEGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice. The spontaneously vascularized corneas of corn1 and Pax6+/- mice and Pax6+/- patients with aniridia are deficient in sflt-1, and recombinant sflt-1 administration restores corneal avascularity in corn1 and Pax6+/- mice. Manatees, the only known creatures uniformly to have vascularized corneas, do not express sflt-1, whereas the avascular corneas of dugongs, also members of the order Sirenia, elephants, the closest extant terrestrial phylogenetic relatives of manatees, and other marine mammals (dolphins and whales) contain sflt-1, indicating that it has a crucial, evolutionarily conserved role. The recognition that sflt-1 is essential for preserving the avascular ambit of the cornea can rationally guide its use as a platform for angiogenic modulators, supports its use in treating neovascular diseases, and might provide insight into the immunological privilege of the cornea.     

Research on community detection algorithm based on site topic similarity and topology

Considering the deviation in content of community detection resulting from the low accuracy of resource relevance,an algorithm based on the topology of sites and the similarity between their topics is proposed. With topic content factors fully considered,this algorithm can search for topically similar site clusters on the premise of inter-site topology. The experimental results show that the algorithm can generate a more accurate result of detection in the real network.     

高速公路出口匝道事故预测模型优选及弹性分析

为探索高速公路出口事故发生的关键诱因,依托美国佛罗里达州24条高速公路上405个出口匝道的历史事故和道路交通数据,验证了出口匝道事故服从于对数正态分布.以匝道交通量、匝道长度和设计一致性(分别以平均半径、曲率变化率、运行速度差和运行速度变化率度量)为解释变量,以2004—2006年间事故数为因变量,建立了4个泊松对数正态事故预测模型,其中以速度变化率表征设计一致性的事故预测模型具有最好的拟合度.基于最优拟合度模型的弹性分析表明,运行速度变化率及匝道长度为关键因素;基于安全考虑,出口匝道速度变化率宜控制在20%以内,出口匝道极限最小长度不宜小于200 m,一般最小长度不宜小于400 m.