Two-dimensional simulation of Poiseuille-Rayleigh-Bénard flows in binary fluids with Soret effect

Poiseuille-Rayleigh-Bénard flows in binary fluids with Soret effect are directly simulated by a mixed finite element method. A temperature perturbation is used as an initial disturbed source for the basic parallel flows. The whole spatio-temporal evolution of the binary fluid flows is exhibited: initially only the disturbed mode with the wavenumber k=π is amplified while others are damped, and continuously the amplified mode grows further and the nonlinear effect becomes important; after a nonlinear evolution transition the flow system evolves finally into a periodic right traveling wave.     

Metallogenic epoch and genesis of the gold deposits in Jiaodong Peninsula, Eastern China: a regional review

Gold deposits are characterized by multi-sources, superimposition, large scale and temporal-spatial concentration in Jiaodong Peninsula, Eastern China. In this paper, we review the history and the development of the study on metallogenic chronology and genesis of gold deposits, summarize the main features of superimposed metallogenesis, provide evidence of the Mesozoic complex metallogenic system, and point out some problems for further research of Jiaodong gold deposit cluster from a regional view. Although gold deposits are different in genetic types, ore-forming materials and geological settings, our research indicates that the accumulation and emplacement of the ore-forming materials are temporally-spatially concentrated on a large scale, and the main metallogenic epoch of Jiaodong gold deposits was concentrated in Mesozoic. Metallogenic chronology and geological-geochemical data indicate that there are two periods of gold mineralizations occurred in 130-110 Ma and 90-80 Ma respectively in Jiaodong ore cluster. The gold deposit cluster results from the superimposition of the polygenetic mineralization, and further study is needed to investigate the formation and evolution of the Mesozoic complex metallogenic system.     

Excitatory effect of histamine on neuronal activity of rat cerebellar fastigial nucleus Jn vitro

The cerebellar fastigial nucleus （FN） holds an important role in motor control and body balance. Previous studies have revealed that the nucleus is innervated by direct hypothalamocerebellar hletaminergic fibers. However, the functional role of histaminergic projection in cerebellar FN has never been established. In this study, we investigated the effect of histamine on neuronal firing of cerebellar FN by using slice preparations. Sixty-five FN cells were recorded from 47 cerebellar slices, and a vast majority of the cells responded to histamine stimulation with an excitatory response （58/65, 89.2%）. Perfusing slices with low-Ca^2＋/high-Mg^2＋ medium did not block the histamine-induced excitation （n=10）, supporting a direct postsynaptic action of histamine on the cells. Furthermore, the excitatory effect of histamine on FN neurons was not blocked by selective histamine H1 receptor antagonist triprolidine （n=15） or chlorpheniramine （n=10）, but was effectively suppressed by ranitidine （n=15）, a highly selective histamine H2 receptor antagonist. On the other hand, highly selective histamine H2 receptor agonist dimaprit （n=20） instead of histamine HI receptor agonist 2-pyridylethylamine （n=16） mimicked the excitatory effect of histamine on FN neurons. The dimaprit-induced FN neuronal excitation was effectively antagonized by selective histamine H2 receptor antagonist ranitidine （n=13） but not influenced by selective histamine H1 receptor antagonist triprolidine （n=15）. These results demonstrate that histamine excites cerebellar FN cells via the histamine H2 receptor mechanism and suggest that the hypothalamocerebellar histaminergic fibers may modulate cerebellar FN-mediated sensorimotor integration through their excitatory innervations on FN neurons.     

Mechanism of the interaction between Au nanoparticles and polymerase in nanoparticle PCR

Nanoparticle PCR is a novel method to optimize DNA amplification. It performs well in improving specificity, enhancing sensitivity and speed. Several mechanisms were proposed in previous studies: one was based on the interaction between gold nanoparticles (AuNPs) and DNA while the other was attributed to the heat transfer property of AuNPs. In this paper, we propose that the interaction between AuNPs and DNA polymerase can significantly influence PCR. First, the addition of DNA polymerase can eliminate the inhibitory effects of excess AuNPs. Second, the addition of AuNPs will increase yield of the desired PCR product and make the optimum concentration of DNA polymerase move to higher value. Third, while excess polymerase might inhibit amplification efficiency, AuNPs can reverse this process and the yield of PCR amplification. Based on these results we propose a possible mechanism that AuNPs might modulate the activity of polymerase and improve PCR amplification.     

Distributed Penalized Modal Regression for Massive Data

Nowadays, researchers are frequently confronted with challenges from massive data computing by a number of limitations of computer primary memory. Modal regression(MR) is a good alternative of the mean regression and likelihood based methods, because of its robustness and high efficiency. To this end, the authors extend MR to massive data analysis and propose a computationally and statistically efficient divide and conquer MR method(DC-MR). The major novelty of this method consists of splitting ...     

An Energy-Saving Task Scheduling Strategy Based on Vacation Queuing Theory in Cloud Computing

High energy consumption is one of the key issues of cloud computing systems. Incoming jobs in cloud computing environments have the nature of randomness, and compute nodes have to be powered on all the time to await incoming tasks. This results in a great waste of energy. An energy-saving task scheduling algorithm based on the vacation queuing model for cloud computing systems is proposed in this paper. First, we use the vacation queuing model with exhaustive service to model the task schedule of a heterogeneous cloud computing system.Next, based on the busy period and busy cycle under steady state, we analyze the expectations of task sojourn time and energy consumption of compute nodes in the heterogeneous cloud computing system. Subsequently, we propose a task scheduling algorithm based on similar tasks to reduce the energy consumption. Simulation results show that the proposed algorithm can reduce the energy consumption of the cloud computing system effectively while meeting the task performance.     

Effect of P15INK4b expression on the cell cycle and G1 phase related regulatory genes in human melanoma cells

Using the transfeetion teehnique. P15INK4b was introduced into P15INk4b gene deleted human melanoma A375 cells,and a cell model MLED6 overexpressing P15INK4b WAS CONSTRUCTED.Comparing with the control cells MLC2,MLEK6cells in G1phase increased by 11%,but those in Sphase decreased by 15%by FCM.By the method of thymidine(TdR)and N2O arresting,the proportions of synchronized Mphase cells of MLEK6 ana MLC23 were measured and found to be 89.1% and 76.8%respectively ,and the cells in G1phase were 74.3% for MLID6 AND 76. 4% forMLC2.The result of3 H-TdR incorporation indicated that the transition of G1/Sof MLEK6 cell was delayed 2h as compared with that of MLC2 cells,and incorporation rate also decreased.The observation on exprissions of some G1/ S-resates relatory rigusating genes showed that in MLIK6 cells the protein leves of P27KIPI increased with the decreasing expressions of cyclinD1,cyclinE and c-myc,especially cyclinD1 in late G1phade.The expression of cyclinE obviously decreased at G1/S transition ,and c-myc wad inhibited throughout all the process of G1 S phase.All the risults suggest that P15INK4b can delayG1/S transition of MLEK6 cells by inhibiting the cell cycle engine ,and by increasing the expression of Cdk ingibitor P27KIPI in different stages of G1 phase.     

Study of Combination Forecasting in Airline Traffic Turnover

There are many sophisticated forecasting methods at present,butitis difficultto getaccurate and reliable resultwith only one method in forecasting practice.Ifmany differentforecasting methods were adopted in one forecasting subject,and combined appropriately,then available information coming from the varied methods was used adequately to improvethe forecasting accuracy.That is the basic idea of the combination forecasting.Bates andGranger first put the combination forecasting method forward at…     

新中国六十年的两次社会转型

新中国成立六十年来,我国经历了两次社会转型.第一次发生于1949--1978年,这次社会转型,使我国从半殖民地半封建社会转变为社会主义中国.第二次发生于党的十一届三中全会到现在,这次社会转型,使我国从传统社会主义转变为中国特色社会主义.两次社会转型紧密联系,第一次社会转型为第二次社会转型打下基层,准备条件;第二次社会转型是第一次社会转型的继续和深化.     

On the Gracefulness of the Digraphs n·Cm＊

A digraph D（V, E） is said to be graceful if there exists an injection f ： V（G） →{0, 1,... , ｜E｜} such that the induced function f＇ ： E（G） --~ {1, 2,… , ｜E｜} which is defined by f＇ （u, v） = [f（v） - f（u）] （rood ｜E｜＋ 1） for every directed edge （u, v） is a bijection. Here, f is called a graceful labeling （graceful numbering） of D（V, E）, while f＇ is called the induced edge＇s graceful labeling of D. In this paper we discuss the gracefulness of the digraph n- Cm and prove that n. Cm is a graceful digraph for m = 15, 17 and even