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11.
<正>淮河淮滨至润河集段航道位于淮河中上游,全长98km,是国家水运主通道的重要部分。该河段蜿蜒曲折,由一系列正反相间的弯道和介于其间的长短不等的过渡段组成。根据碍航段类型可区分为4种:顺直过渡段浅滩、汊道型浅滩、弯道碍航段、 相似文献
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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease 总被引:1,自引:0,他引:1
Naj AC Jun G Beecham GW Wang LS Vardarajan BN Buros J Gallins PJ Buxbaum JD Jarvik GP Crane PK Larson EB Bird TD Boeve BF Graff-Radford NR De Jager PL Evans D Schneider JA Carrasquillo MM Ertekin-Taner N Younkin SG Cruchaga C Kauwe JS Nowotny P Kramer P Hardy J Huentelman MJ Myers AJ Barmada MM Demirci FY Baldwin CT Green RC Rogaeva E St George-Hyslop P Arnold SE Barber R Beach T Bigio EH Bowen JD Boxer A Burke JR Cairns NJ Carlson CS Carney RM Carroll SL Chui HC Clark DG Corneveaux J Cotman CW 《Nature genetics》2011,43(5):436-441
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and two replication stages (stages 2 and 3). Both joint analysis and meta-analysis approaches were used. We obtained genome-wide significant results at MS4A4A (rs4938933; stages 1 and 2, meta-analysis P (P(M)) = 1.7 × 10(-9), joint analysis P (P(J)) = 1.7 × 10(-9); stages 1, 2 and 3, P(M) = 8.2 × 10(-12)), CD2AP (rs9349407; stages 1, 2 and 3, P(M) = 8.6 × 10(-9)), EPHA1 (rs11767557; stages 1, 2 and 3, P(M) = 6.0 × 10(-10)) and CD33 (rs3865444; stages 1, 2 and 3, P(M) = 1.6 × 10(-9)). We also replicated previous associations at CR1 (rs6701713; P(M) = 4.6 × 10(-10), P(J) = 5.2 × 10(-11)), CLU (rs1532278; P(M) = 8.3 × 10(-8), P(J) = 1.9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility. 相似文献
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武器装备的供给应着力于构建"寡头主导、大中小企业分层竞争"的产业组织结构。采办方应设计最优的主承包招标机制,以促进各寡头企业之间的投标竞争,从而实现最佳采办效益。武器装备采办的分层次竞争不完全取决于采办方的竞争意愿,其还要受到武器装备供给企业的产权安排、军民融合程度、纵向一体化及采办代理人制度等多种因素的影响。 相似文献
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Secondary instabilities of linearly heated failing films are studied through three steps. Firstly, the analysis of the primary linear instability on Miladinova's long wave equation of the linearly heated film is performed. Secondly, the similar Landau equation is derived through weak nonlinear theory, and a two-dimensional nonlinear saturation solution of primary instability is obtained within the weak nonlinear domain. Thirdly, the secondary (three-dimensional) instability of the two-dimensional wave is studied by the Floquet theorem.Our secondary instability analysis shows that the Marangoni number has destabilization effect on the secondary instability. 相似文献
16.
Original component of grain size index in core sediment from southwestern slope of the South China Sea and its paleoenvironmental implication 总被引:1,自引:0,他引:1
CHEN Muhong ZHENG Fan LU Jun XIAO Shangbin YAN Wen CHEN Zhong XIANG Rong WEI Gangjian & ZHANG Lanlan . South China Sea Institute of Oceanology Chinese Academy of Sci- ences Guangzhou China . Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou China Correspondence should be addressed to Chen Muhong 《科学通报(英文版)》2005,50(9):896-902
Traditional grain size analysis was basically used to discriminate sediment type based on its particle dimension for sedimentary naming[1,2] and to analyze the dynamic feature of transport medium, including water current and wind strength[3―5]. Recently, some patency advances havebeen made by using different methods to separate different grain sizes in various original composition from sediments for searching a new way of paleoenvironmental study[6―8]. Grain size analysis is even playing an … 相似文献
17.
NING Xinbao BIAN Chunhua WANG Jun CHEN Ying 《科学通报(英文版)》2006,51(4):385-393
1INTRODUCTION THE WORLD IS NONLINEAR,AND THE HUMAN LIFE ACTIVITY IS ALSO NONLINEAR.FROM THE VIEWPOINT OF SYSTEM,HUMAN BEINGS(OR THE OTHER HIGHER ANIMAL)ARE THE MOST COM-PLEX SYSTEM IN THE NATURE.FOR SUCH A PHYSIOLOGICAL SYS-TEM WITH THE UTTERMOST COMPLEXI… 相似文献
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LUO Xin WEI Jun 《武汉大学学报:自然科学英文版》2006,11(3):657-661
0 IntroductionTihse a f agilruardeu aolf pcroonccerseste wshuibcjhec itsed ditfofe ernenvitr ofrnommentthale afcatiilounrespatternin general strengthtest .The change of material statescaused by the damage evolution will affect the concretestrengthin a certain kind of concrete.For years ,domestic studies have focused on the effect ofabominable environmental factors on mechanical property ofconcrete,and have resulted in some achievements[1-12]. Thestudies of some current research results reveal … 相似文献
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ZHANG Jun KOU Weidong FAN Kai CAO Xuefei 《武汉大学学报:自然科学英文版》2006,11(6):1671-1674
A trusted third party introduced in watermarking protocols would decrease the security and affect the implementation of the protocols. In this paper, a new watermarking protocol with an un-trusted third party (UTTP) was proposed. Based on the idea of all-or-nothing disclosure of secret (ANDOS), all of the buyer, the seller and the third party didn't know the exact watermark, which was embedded in a digital content for tracing piracy. The proposed protocol provided mechanisms to trace piracy and protect customer's right. In addition, the problem that a seller colluded with UTTP to frame the buyer, namely, the conspiracy problem, could be avoided. 相似文献