Early Diagnostic Value of Circulating MiRNA-21 in Lung Cancer： A Meta-Analysis

To evaluate the early diagnostic value of circulating miRNA-21 in diagnosis of lung cancer, databases such as Wan Fang, VIP, PubMed, and Elsevier were systematically searched from 2005 to 2013 to collect relevant references in which the diagnostic value had been evaluated. The statistics were consolidated and the qualities of the studies were classified. The data were analyzed using Meta Disc1.4 software. The diagnostic value of circulating miRNA-21 in lung cancer was assessed by pooling sensitivity, specificity, the likelihood ratio, and the Summary Receiver Operating Characteristic(SROC) curve. Publication biases of the studies involved were analyzed using Stata 11.0 software. A total of 143 papers were collected of which 8 were included, which contained 600 cases and440 controls. A heterogeneity test proved the existence of homogeneity in this study. Upon analysis using random effects models, the weighted sensitivity was 0.68, the specificity 0.77, the positive likelihood ratio 2.84, the negative likelihood ratio 0.40, and the SROC Area Under the Curve(AUC) was 0.8133. Further analysis by subgroup showed that the 5 indicators mentioned above were 0.72, 0.84, 4.50, 0.27, and 0.8987, respectively, for the serum group and 0.63, 0.70, 1.95, 0.53, and 0.7318, respectively, for the plasma group. We conclude that circulating miRNA-21can be regarded a valuable reference in diagnosis of lung cancer. This research showed that in lung cancer the early diagnostic value of miRNA-21 in serum was better than that in plasma.     

Fabrication of solenoid-type microinductor with different magnetic core schemes by MEMS technique

0 IntroductionThere has been a great demand on micro DC/DCconverter for the applications of the portable electronicproducts such as mobile communication product CDMA(Code Division Multiple Access) ,portable notebookcom-puter ,microprocessor ,digital camcorder andso on.Mag-netic components such as inductors and transformers arethe essential components in constructingthe power supplytransformer ,filter , oscillator , amplifier and micro DC/DCconverter ,andthe miniaturization of inductor an…     

Inverse minimum spanning tree problem and reverse shortest-path problem with discrete values

In this paper, we consider two network improvement problems with given discrete values: the inverse minimum spanning tree problem and the reverse shortest-path problem, where the decrements of the weight of the edges are given discrete values. First, for the three models of the inverse minimum spanning tree problem (the sum-type, the bottleneck-type and the constrained bottleneck-type), we present their respective strongly polynomial algorithms. Then， we show that the reverse shortest-path problem is strongly NP-complete.     

Concentration level and distribution of polycyclic aromatic hydrocarbons in soil and grass around Mt. Qomolangma, China

High mountains may serve as a condenser for persistent organic pollutants. In the present study, soil and grass samples from Mt. Qomolangma region, China were collected from 4600 to 5620 m a.s.I and were analyzed for polycyclic aromatic hydrocarbons （PAHs） to determine if they are concentrated at colder, more elevated sites and to evaluate their possible resources and fractionation. The total PAHs concentration in soil samples was 〈 600 ng g^-1, the critical value to differentiate PAHs levels in remote and urban regions. This implied the PAHs levels at Mt. Qomolangma are relatively low and what one might expect in such a remote region of the world. These low values may represent a soil background for mid-latitude Northern Hemisphere soils away from the direct influence of an anthropogenic source. As for the distribution pattern, the low molecular weight PAHs were prone to accumulate at higher altitude, while the high molecular weight PAHs inversely related or unrelated with elevation. Based on high concentration of phenanthrene at elevated sample site and the ratios of individual PAHs, we deduced that home-heating combustion and vehicle emission may result in the constitution trait of PAHs in this mountain region. Monsoon traveling over India, Pakistan and other countries with dense population may carry contaminant to Mt. Qomolangma region.     

集群存储技术及其在石油勘探行业的应用

随着海量数据的迅猛增长,尤其是非结构化数据爆炸性增长,非结构化数据所占比例越来越高,对存储系统的高性能、可靠性和可扩展性提出了很高的要求,使得传统存储系统已经不能满足所有用户的需求,集群存储技术和产品应运而生。集群存储技术以它的高性能、高可用性、高可扩展性和易于管理等特性赢得了用户的青睐。在集群存储技术应用到石油勘探行业的数据处理高性能计算系统中,可以很好地满足该行业地震数据处理系统的大文件海量存储、高带宽和高性能等要求,明显提高了系统数据处理速度。     

Single-cell discrimination based on optical tweezers Raman spectroscopy

The ability to discriminate between single cells in a label-free and noninvasive fashion is important for the classification of cells, and for the identification of similar cells from different origins. In this paper, we present the Raman spectroscopy-based identifi- cation of different types of single cells in aqueous media, and discrimination between the same types of cells from different donors using a novel Laser Tweezers Raman Spectroscopy (LTRS) technique, which combines laser trapping and micro-Raman spectroscopy. First, we measured the spectra of individual living human erythrocytes, i.e. red blood cells, and leucocytes (U937 cancer cells). High-quality Raman spectra with low fluorescence were obtained using a home-LTRS apparatus and 20 cells were measured for each cell type. The smoothing, baseline subtraction, and normalization of the data were followed by a principal components analysis (PCA). The PCA loading plots showed that the two different types of cells could be completely separated based only on the first component (PC1) (i.e. the peaks at 1300 cm1 ); the discrimination accuracy could therefore reach 100%. More than 50 spectra were taken for each erythrocyte obtained from the four healthy volunteers. The average discrimination accuracy was 84.5% for two random individuals taken from the four volunteers, according to the first and second PCs. This work demonstrates that LTRS is a powerful tool for the accurate identification and discrimination of single cells, and it has the potential to be applied for the highly sensitive identification of cells in clinical diagnosis and medical jurisprudence.     

国家科技计划管理体系改革概况

科技计划由目标、期限、范围、组织机构和实施方案等要素组成．是政府组织科技活动的基本形式之一；是政府有目标、有步骤、有组织、有措施地开展科技活动的基本组织形式之一；是体现政府目标、弥补市场不足的重要手段；是实现科技政策目标的重要政策工具。世界各国的科技计划大致分为五类：基础研究计划、公益技术研究计划、战略技术发展计划、政策引导性计划、战略任务型科技专项计划。     

家居多功能远程警报系统设计

本设计以单片机AT89C51作为核心控制器,集红外线监控,自动拨号报警．防火、防盗、防漏煤气、防烟,实时监控等功能,具有操作简单、体积小．安装方便和高性比价,高可靠性等特点,适合现代家居的安全使用。     

Centromere inactivation in a dicentric rice chromosome during sexual reproduction

T0135 is a variant selected from the progeny of a rice line telotrisomic for the short arm of chromosome 11 （2n＋IIS＇）. Fluores- cent in situ hybridization （FISH） results indicated that T0135 contained two telocentric chromosomes, which have two centro- mere-specific molecular markers （5S rDNA） for chromosome 11; thus T0135 is a newly-described rice chromosome variant with two dicentric chromosomes, named 22＋11L-＋11L＇＋I IS.11S-＋I 1S-11S. （22 represents the 22 chromosomes excluding chromo- some 11 in the rice genome, ＂-＂ represents the centromere）. To investigate the genetic stability of the rice dicentric chromosomes during sexual reproduction, we observed the chromosome types in the progeny. Ninety-four percent of the progeny had the same chromosome type as the parental line. This result indicates that the dicentric chromosomes are mostly stable during mitosis and meiosis. Immunofluorescence analysis for centromere specific histone H3 （CENH3） revealed that only one centromere is active and the other centromere is inactivated in the rice dicentric chromosomes.