Penetration of oximes across the blood-brain barrier. A histochemical study of the cerebral cholinesterases reactivation

Summary The comparison of the effects of 4 oximes upon the cerebral cholinesterases reactivation after intoxication with paraoxon shows that the best results are obtained with toxogonine and 1574 [(carbaldoxime-4 pyridinium)-1(methyl-1 imidazolium-3)-3 propane]. The reactivation power of this latter compound seems due to the ease with which it can pass through the blood-brain barrier.Supported by grants from the Direction des Recherches et Etudes Techniques (D.R.E.T.) (No. 77–275).     

MethylTrans-monocyclofarnesate from the spongeHalichondria panicea

Riassunto L'estere metilico dell'acidotrans-monociclofarnesico (5) è stato ora isolato dalla spugnaHalichondria panicea. Il suo rinvenimento nello stesso organismo, dal quale erano state isolate precedentemente le paniceine. (1–3), supporta l'ipotesi che la parte sesquiterpenoidica di quest'ultime si origini biogeneticamente da un precursore monociclofarnesilico.     

Etude de l'agrégation plaquettaire par le Thrombofax

Summary Thrombofax Ortho is a stable, reproducible, ready-to-use reagent for the evaluation of the platelet release reaction.

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Recherches effectuées avec l'appui financier du Fonds voor Wetensschappelijik Geneeskundig Onderzoek, Brussel (contrat No. 1216).