Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common and rare variants explain only a small proportion of the heritability of T2D. As previously published analyses had limited power to identify variants with modest effects, we carried out meta-analysis of three T2D GWA scans comprising 10,128 individuals of European descent and approximately 2.2 million SNPs (directly genotyped and imputed), followed by replication testing in an independent sample with an effective sample size of up to 53,975. We detected at least six previously unknown loci with robust evidence for association, including the JAZF1 (P = 5.0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D.     

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis

We identified a SNP in the DPP6 gene that is consistently strongly associated with susceptibility to amyotrophic lateral sclerosis (ALS) in different populations of European ancestry, with an overall P value of 5.04 x 10(-8) in 1,767 cases and 1,916 healthy controls and with an odds ratio of 1.30 (95% confidence interval (CI) of 1.18-1.43). Our finding is the first report of a genome-wide significant association with sporadic ALS and may be a target for future functional studies.     

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12. Each copy of the European ancestral allele conferred a relative risk of 0.50 (95% CI = 0.39-0.63) compared to African ancestry. Multiple common SNPs (allele frequencies ranging from 0.2 to 0.6) in the gene encoding nonmuscle myosin heavy chain type II isoform A (MYH9) were associated with two to four times greater risk of nondiabetic ESRD and accounted for a large proportion of the excess risk of ESRD observed in African compared to European Americans.     

斜拉桥索梁锚固结构疲劳试验模型设计优化

为了避免出现斜拉桥索梁锚固结构疲劳试验中辅助部分首先断裂的问题,在以往试验模型设计的基础上,考虑影响疲劳寿命的不同因素,建立了以模型的静力强度、位移、疲劳和断裂性能为模糊约束条件,以模型质量、疲劳和断裂寿命为多个目标的结构多目标优化设计模型.结合苏州南通长江公路大桥钢锚箱式索梁锚固结构足尺疲劳试验,验证了锚箱式索梁锚固结构设计的正确性,经过400万次加载而未破坏,且减少了模型用钢量.模型设计中提出的控制热点应力等措施切实可行.     

基于VRS技术的GPS接收系统设计与实现

介绍了虚拟参考站系统的组成、工作原理及优势,并研究开发了一套基于VRS技术的GPS接收系统．该系统由单片机、AC12 GPS模块、GSM模块、键盘模块、液晶显示模块和U盘存储模块等组成,可接收以GSM方式发送的GPS差分信息,并对差分后的位置数据进行存储和显示．试验表明：设计研发的系统工作稳定,采用VRS差分后定位精度达到1．25m（95％）,能满足精细农作管理的基本要求,适用于农田信息采集、面积测量等多种作业．     

Irrigation-induced pollution of organochlorine pesticides and polychlorinated biphenyls in paddy field ecosystem of Liaohe River Plain, China

In order to assess the influence of long-term irrigation of polluted river water on the ecological health of the rice fields in the low reach of Liaohe River Plain,a series of environmental samples and biological samples in rice fields,including sediments,paddy soils,mitten-handed crabs(Eriocheir sinensis),loaches(Misgurnus anguillicaudatu) and frog(Hoplobatrachus tigerinus),were collected from the area far away from industrial zones,and polychlorinated biphenyls(PCBs) and organochlorine pesticides(HCH,DDT,HCB and Mirex) were analyzed by high resolution gas chromatography coupled with high resolution mass spectrometry(HRGC/HRMS).The comparison of pollutant concentrations and profiles verified that the significant contribution of river water irrigation to PCBs contaminations in paddy soils and the mutual influence of organochlorine pesticide contamination between river sediments and paddy soils.Bioaccumulations of PCBs and organochlorine pesticides in mitten-handed crabs and loaches were site-specific,suggested that they were both the good indicators of ecosystem health.Mitten-handed crabs had the highest capacity to accumulate PCBs and organochlorine pesticides,and also they had the strong ability to degrade these pollutants in their bodies,especially for DDT and HCH.The biota-soil accumulation factors(BSAF) of ΣH CH,ΣDDT,Mirex,HCB and ΣP CBs in mitten-handed crab were calculated to be 24.5,15.3,122.2,28.1 and 54.6,respectively.In view of the strong bioaccumulation ability,the health risk should be concerned for the cultivation of mitten-handed crabs in paddy fields in the low reach of Liaohe River Plain.     

对现今网络语言的几点思考

从语言的本质、语言的听觉符号转移、网络语言在网络上流行和接受的程度以及网络语言的结构类型来看,网络语言的存在和发展有合理的因素.然而,网络语言不符合语言变化的规律,它具有不稳定性和随意性.网络语言的出现,使我们看清语言文字所面临的挑战和机遇,利用现代化信息技术手段,对重要社会领域的语言文字使用状况进行监测、分析与研究,提升语言文字的规范化、标准化和信息化水平.