The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.     

Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors

The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.     

Variation in complement factor 3 is associated with risk of age-related macular degeneration

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.     

Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans

More than a billion humans worldwide are predicted to be completely deficient in the fast skeletal muscle fiber protein alpha-actinin-3 owing to homozygosity for a premature stop codon polymorphism, R577X, in the ACTN3 gene. The R577X polymorphism is associated with elite athlete status and human muscle performance, suggesting that alpha-actinin-3 deficiency influences the function of fast muscle fibers. Here we show that loss of alpha-actinin-3 expression in a knockout mouse model results in a shift in muscle metabolism toward the more efficient aerobic pathway and an increase in intrinsic endurance performance. In addition, we demonstrate that the genomic region surrounding the 577X null allele shows low levels of genetic variation and recombination in individuals of European and East Asian descent, consistent with strong, recent positive selection. We propose that the 577X allele has been positively selected in some human populations owing to its effect on skeletal muscle metabolism.     

Automatic patent document summarization for collaborative knowledge systems and services

Engineering and research teams often develop new products and technologies by referring to inventions described in patent databases. Efficient patent analysis builds R&D knowledge, reduces new product development time, increases market success, and reduces potential patent infringement. Thus, it is beneficial to automatically and systematically extract information from patent documents in order to improve knowledge sharing and collaboration among R&D team members. In this research, patents are summarized using a combined ontology based and TF-IDF concept clustering approach. The ontology captures the general knowledge and core meaning of patents in a given domain. Then, the proposed methodology extracts, clusters, and integrates the content of a patent to derive a summary and a cluster tree diagram of key terms. Patents from the International Patent Classification (IPC) codes B25C, B25D, B25F (categories for power hand tools) and B24B, C09G and H011 (categories for chemical mechanical polishing) are used as case studies to evaluate the compression ratio, retention ratio, and classification accuracy of the summarization results. The evaluation uses statistics to represent the summary generation and its compression ratio, the ontology based keyword extraction retention ratio, and the summary classification accuracy. The results show that the ontology based approach yields about the same compression ratio as previous non-ontology based research but yields on average an 11% improvement for the retention ratio and a 14% improvement for classification accuracy.     

Modeling Organizational Systems: Banathy's Three Lenses Revisited

The inherent complexity of organizational systems defies full understanding by inquirers. This condition often causes organizational inquirers to become mired in convoluted deliberations, unable to attain the consensus among the inquiring community that is needed to advance the research forward to a meaningful conclusion. Consequently, many practitioners and researchers employ models of organizations to aid in simplifying the system's complexity and to reach shared agreement. Because no single model can fully capture the complexity of an organization, Dr. Bela H. Banathy therefore proposed using three types of interrelated models to give a multidimensional view of a human system under study. Since Banathy first introduced his three lenses approach, the concept has been employed in many educational and organizational settings. This article examines the author's experience using Banathy's three lenses and integrates their usage with some other popular modeling techniques, providing a comprehensive view of how Banathy's three lenses can be effectively employed in contemporary organizational settings.     

Pragmatic Approach to Adaptive Turbo Coded Modulation

This paper presents a pragmatic adaptive scheme for TuCM over slowly fading channels. The adaptive scheme employs a single turbo coded modulator composed of a variable-rate turbo encoder and a variable-rate variable-power MQAM for all fading regions, so it has an acceptable complexity to implement. The optimal adaptive TuCM scheme is determined subject to various system constraints. Simulations have been performed to measure the performance of the scheme for different parameters. It is shown that adopting both the turbo coded modulator and the transmit power achieves a performance within 2.5 dB of the fading channel capacity.     

存款准备金率变动对股市影响的实证研究

运用VAR模型的G ranger因果检验和脉冲响应函数分析研究了中央银行存款准备金率变动对沪深300指数的影响,并通过方差分解分析前者对后者的贡献度。得出的结论是存款准备金率变动对股市波动在短期内存在一定负方向的影响,股市波动对存款准备金率则无影响。但在长期内,存款准备金率变动对股市影响很小。最后在此基础上提出相关的货币政策的建议。     

Pre-processing for time domain image formation in SS-BSAR system

A pre-processing procedure is designed for a space-surface bistatic synthetic aperture radar (SS-BSAR) system when a time domain image formation algorithm is employed. Three crucial technical issues relating to the procedure are fully discussed. Firstly, unlike image formation algorithms operating in the frequency domain, a time domain algorithm requires the accurate global navigation satellite system (GNSS) time and position. This paper proposes acquisition of this information using a time-and-spatial transfer with precise ephemeris and interpolation. Secondly, synchronization errors and compensation methods in SS-BSAR are analyzed. Finally, taking the non-ideal factors in the echo and the compatibility of image formation algorithms into account, a matched filter based on the minimum delay is constructed. Experimental result using real data suggest the pre-processing is functioning properly.