P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips.

Escherichia coli is a frequent cause of several common bacterial infections in humans and animals, including urinary tract infections, bacteraemia and bacteria-related diarrhoea and is also the main cause of neonatal meningitis. Microbial attachment to surfaces is a key event in colonization and infection and results mainly from a stereochemical fit between microbial adhesins and complementary receptors on host cells. Bacterial adhesins required for extracellular colonization by Gram-negative bacteria are often minor components of heteropolymeric fibres called pili which must be oriented in an accessible manner in these structures to be able to bind to specific receptor architectures. P pili mediate the binding of uropathogenic E. coli to a digalactoside receptor determinant present in the urinary tract epithelium. We report here that the adhesin is a component of distinct fibrillar structures present at the tips of the pili. These virulence-associated tip fibrillae are thin, flexible polymers composed mostly of repeating subunits of PapE that frequently terminate with the alpha-D-galactopyranosyl-(1-4)-beta-D-galactopyranose or Gal alpha (1-4)Gal binding PapG adhesin.     

足球裁判员控制比赛气氛的探讨

足球裁判员有效地控制比赛气氛是圆满完成裁判工作的重要课题,我们对比赛气氛的变化规律进行分析研究后,制订的控制对策与方法经临场实践取得了较好的效果.     

单片机在数控机床上的应用研究

本文研究将ＭＣＳ－５１型单片机用于普通数控机床，通过监控程序设计，进一步完善机床性能，使该系统具有显示功能，快速点动、自动四零、自动升降频率、自动换刀、自动齿隙补偿、刀具磨损补偿，暂停等多种功能．     

SYNTHESIS AND CHARACTERIZATION OF MONOVALENT AND MIXED-VALENCE COMPLEXES OF COPPER WITH 2-THIOURACIL

Five polynuclear monovalent and mixed-valence complexes of copper with 2-thiouracil were synthesized. They were characterized by the molar conductivity, electromc spectra, infrared spectroscopy, thermogravimetric and magnetic susceptibility measurements. Their coordination properties and tentative structures were discussed.     

处理优化约束条件的微分方程法

在文[1]中,作者曾提出求解一般约束优化问题的一种新方法。本文利用微分方程对约束条件做进一步的讨论,证明了从一可行点的某邻域出发的该微分方程组的解关于部分变元总收敛到问题(1.1)的可行点。     

基于可能性理论的柴油机故障诊断方法

本文提出了基于可能性测度的柴油机故障诊断方法.与概率测度相比,可能性测度更为适合,计算更为简单,在故障诊断中有着广泛的适用性。     

透射和反射组合系统的基点基面

本文研究了由透射和反射系统构成的组合系统的基点基面,推导出了其位置公式,结果表明这样的组合系统等效于一个反射镜,等效反射镜就是反射系统经透射系统所成的象,最后对其性质进行了讨论.     

The humoral immune response to heat shock proteins.

Humoral immune reactions to heat shock proteins (hsp) from microorganisms are one aspect of microbial infections in humans. The production of antibodies which are specific to epitopes present on procaryotic hsp leads also to the appearance of cross-reactive serum antibodies in the host organism that react with human hsp. This article discusses the consequences of such autoreactive antibodies for the host in context with the development of immune tolerance and autoimmune diseases, especially rheumatoid arthritis (RA), and in experimental animal models for arthritis such as adjuvant arthritis in rats. On the basis of epitope cross-reactivity between hsp and other host proteins, a hypothesis is presented for the development of autoimmune disease following the production of hsp-specific antibodies.