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排序方式: 共有63条查询结果,搜索用时 46 毫秒
51.
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This paper considers a correlated risk model with thinning-dependence structure.The authors investigate the optimal proportional reinsurance that maximizes the adjustment coefficient and the optimal proportional reinsurance under mean variance principle for the proposed model.The authors derive the optimal solutions and the numerical illustrations to show the impact of the dependence among the classes of business on the optimal reinsurance arrangements. 相似文献
53.
Rivière JB van Bon BW Hoischen A Kholmanskikh SS O'Roak BJ Gilissen C Gijsen S Sullivan CT Christian SL Abdul-Rahman OA Atkin JF Chassaing N Drouin-Garraud V Fry AE Fryns JP Gripp KW Kempers M Kleefstra T Mancini GM Nowaczyk MJ van Ravenswaaij-Arts CM Roscioli T Marble M Rosenfeld JA Siu VM de Vries BB Shendure J Verloes A Veltman JA Brunner HG Ross ME Pilz DT Dobyns WB 《Nature genetics》2012,44(4):440-4, S1-2
Brain malformations are individually rare but collectively common causes of developmental disabilities. Many forms of malformation occur sporadically and are associated with reduced reproductive fitness, pointing to a causative role for de novo mutations. Here, we report a study of Baraitser-Winter syndrome, a well-defined disorder characterized by distinct craniofacial features, ocular colobomata and neuronal migration defect. Using whole-exome sequencing of three proband-parent trios, we identified de novo missense changes in the cytoplasmic actin-encoding genes ACTB and ACTG1 in one and two probands, respectively. Sequencing of both genes in 15 additional affected individuals identified disease-causing mutations in all probands, including two recurrent de novo alterations (ACTB, encoding p.Arg196His, and ACTG1, encoding p.Ser155Phe). Our results confirm that trio-based exome sequencing is a powerful approach to discover genes causing sporadic developmental disorders, emphasize the overlapping roles of cytoplasmic actin proteins in development and suggest that Baraitser-Winter syndrome is the predominant phenotype associated with mutation of these two genes. 相似文献
54.
Wang K Kan J Yuen ST Shi ST Chu KM Law S Chan TL Kan Z Chan AS Tsui WY Lee SP Ho SL Chan AK Cheng GH Roberts PC Rejto PA Gibson NW Pocalyko DJ Mao M Xu J Leung SY 《Nature genetics》2011,43(12):1219-1223
Gastric cancer is a heterogeneous disease with multiple environmental etiologies and alternative pathways of carcinogenesis. Beyond mutations in TP53, alterations in other genes or pathways account for only small subsets of the disease. We performed exome sequencing of 22 gastric cancer samples and identified previously unreported mutated genes and pathway alterations; in particular, we found genes involved in chromatin modification to be commonly mutated. A downstream validation study confirmed frequent inactivating mutations or protein deficiency of ARID1A, which encodes a member of the SWI-SNF chromatin remodeling family, in 83% of gastric cancers with microsatellite instability (MSI), 73% of those with Epstein-Barr virus (EBV) infection and 11% of those that were not infected with EBV and microsatellite stable (MSS). The mutation spectrum for ARID1A differs between molecular subtypes of gastric cancer, and mutation prevalence is negatively associated with mutations in TP53. Clinically, ARID1A alterations were associated with better prognosis in a stage-independent manner. These results reveal the genomic landscape, and highlight the importance of chromatin remodeling, in the molecular taxonomy of gastric cancer. 相似文献
55.
提出了一种直观,高效地用于概念设计作用图的等手输入,进行几何变形的方法,采用此方法可以徒手输入两笔曲线(参考曲线和目标曲线),并据此二曲线来移动多边形模型的顶点,从而达到变形三维模型的目的,解决了大曲率变形时产生的自相关问题,另外,还可用来定义变形影响区域。 相似文献
56.
采用网格再划分技术的网格推延造型 总被引:1,自引:1,他引:0
提出了一种对自由多边形物体直观高效的三维网格推延造型方法,采用这种造型方法,用户可以在已有的三维物体上勾勒两笔二维轮廓,从而推延了新的空间网格曲面,阐述了两种网格再划分技术,网格优化和网格细分,在此基础上,详细介绍了网格推延造型的方法,该方法能广泛地应用于多边形物体的自由造型。 相似文献
57.
Chan P. M. Yuen C. W. M. Yeung K. W.Institute of Textiles Clothing The Hong Kang Polytechnic University Hong Kong 《东华大学学报(英文版)》1999,(2)
The central composition experimental design of multiva-riate Response Surface Method was used to formulate mathematical models aiming to predict (1) the optimum dyeing conditions of simulated waste Tikuanyin tea for wool fabric and (2) the optimum extraction conditions of a natural mordant originated from common waste eggshell. The pre - mordanting eggshell was applied to wool fabric before dyeing with simulated waste Tikuanyin tea under the optimum dyeing conditions. After mordanting the wool fabric with extracted natural eggshell solution, the prominent effect of increment in dye uptake and improvement of the properties of light fastness, washing fastness and rubbing fastness were evaluated. 相似文献
58.
Unusual stable isotope ratios in amino acid and carboxylic acid extracts from the Murchison meteorite 总被引:3,自引:0,他引:3
Much effort has been directed to analyses of organic compounds in carbonaceous chondrites because of their implications for organic chemical evolution and the origin of life. We have determined the isotopic composition of hydrogen, nitrogen and carbon in amino acid and monocarboxylic acid extracts from the Murchison meteorite. The unusually high D/H and 15N/14N ratios in the amino acid fraction (delta D = 1,370% after correction for isotope exchange; delta 15N = 90) are uniquely characteristic of known interstellar organic materials. The delta D value of the monocarboxylic acid fraction is lower (377%), but still consistent with an interstellar origin. These results confirm the extraterrestrial origin of both classes of compound, and provide the first evidence suggesting a direct relationship between the massive organo-synthesis occurring in interstellar clouds and the presence of pre-biotic compounds in primitive planetary bodies. The isotope data also bear on the historical problem of distinguishing indigenous material from terrestrial contaminants. 相似文献
59.
Yuen Ron Shen Department of Physics University of California Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley CA USA 《清华大学学报》1998,(1)
WhatareExcitinginLaserScienceYuen-RonShenDepartmentofPhysics,UniversityofCaliforniaMaterialsSciencesDivisionLawrenceBerkeleyN... 相似文献
60.
1,2,3,4 - butanetetracarboxylic acid (BTCA) offers an alternative to the conventional N-methlol compounds as a crosslinking agent for cellulose textiles. Cellulase treatment is an effective method to improve the handle of the cotton fabric. Thus it is of particular interest to treat cotton fabric using cellulose and BTCA simultaneously. In this study, BTCA was applied to the cellulase pre-treated cotton fabric, and softener was also used. The results show that the treated fabric does not only have good wrinkle-free property but also good handle. 相似文献