排序方式: 共有25条查询结果,搜索用时 187 毫秒
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Yamaji M Seki Y Kurimoto K Yabuta Y Yuasa M Shigeta M Yamanaka K Ohinata Y Saitou M 《Nature genetics》2008,40(8):1016-1022
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O'Donovan MC Craddock N Norton N Williams H Peirce T Moskvina V Nikolov I Hamshere M Carroll L Georgieva L Dwyer S Holmans P Marchini JL Spencer CC Howie B Leung HT Hartmann AM Möller HJ Morris DW Shi Y Feng G Hoffmann P Propping P Vasilescu C Maier W Rietschel M Zammit S Schumacher J Quinn EM Schulze TG Williams NM Giegling I Iwata N Ikeda M Darvasi A Shifman S He L Duan J Sanders AR Levinson DF Gejman PV Cichon S Nöthen MM Gill M Corvin A Rujescu D Kirov G Owen MJ Buccola NG Mowry BJ 《Nature genetics》2008,40(9):1053-1055
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. Of 12 loci followed up, 3 had strong independent support (P < 5 x 10(-4)), and the overall pattern of replication was unlikely to occur by chance (P = 9 x 10(-8)). Meta-analysis provided strongest evidence for association around ZNF804A (P = 1.61 x 10(-7)) and this strengthened when the affected phenotype included bipolar disorder (P = 9.96 x 10(-9)). 相似文献
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Sulfur is an advantageous material as a promising next-generation positive electrode material for high-energy lithium batteries due to a high theoretical capacity of 1672 m A h g 1although its discharge potential is somewhat modest:ca.2 V vs Li/Lit.However,a sulfur positive electrode has some crucial problems for practical use,which are mainly attributed to the dissolution of its intermediate products in charge–discharge processes.In order to resolve the dissolution problem of lithium polysulfide,we attempted to synthesize a sulfur–microporous activated carbon(AC) composite positive electrode.Moreover,we have systematically researched the battery performance of sulfur–microporous AC positive electrode with variations of electrolytes as well as negative electrodes,and found its promising positive electrode performance for a nextgeneration rechargeable battery. 相似文献
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Furuyama K Kawaguchi Y Akiyama H Horiguchi M Kodama S Kuhara T Hosokawa S Elbahrawy A Soeda T Koizumi M Masui T Kawaguchi M Takaori K Doi R Nishi E Kakinoki R Deng JM Behringer RR Nakamura T Uemoto S 《Nature genetics》2011,43(1):34-41
The liver and exocrine pancreas share a common structure, with functioning units (hepatic plates and pancreatic acini) connected to the ductal tree. Here we show that Sox9 is expressed throughout the biliary and pancreatic ductal epithelia, which are connected to the intestinal stem-cell zone. Cre-based lineage tracing showed that adult intestinal cells, hepatocytes and pancreatic acinar cells are supplied physiologically from Sox9-expressing progenitors. Combination of lineage analysis and hepatic injury experiments showed involvement of Sox9-positive precursors in liver regeneration. Embryonic pancreatic Sox9-expressing cells differentiate into all types of mature cells, but their capacity for endocrine differentiation diminishes shortly after birth, when endocrine cells detach from the epithelial lining of the ducts and form the islets of Langerhans. We observed a developmental switch in the hepatic progenitor cell type from Sox9-negative to Sox9-positive progenitors as the biliary tree develops. These results suggest interdependence between the structure and homeostasis of endodermal organs, with Sox9 expression being linked to progenitor status. 相似文献