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51.
N. Akaike K. Hattori Y. Oomura D. O. Carpenter 《Cellular and molecular life sciences : CMLS》1985,41(1):70-71
Summary Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for -aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.To whom reprint requests should be addressed.Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments. 相似文献
52.
Summary It was found that cell-free extracts ofSaccharomyces cerevisiae contain thiaminase II which hydrolyzes thiamine and thiamine analogs. The possible involvement of this enzyme and thiamine-synthesizing enzymes in thiamine production from thiamine antagonists is discussed.30 September 1986Acknowledgments. We thank the late Dr S. Yurugi, Takeda Pharmaceutical Industries, Osaka, for his generous gifts of dimethialium, 2-northiamine, -hydroxyethylthiamine, hydroxymethylpyrimidine, 2-norhydroxymethylpyrimidine and hydroxyethylthiazole. We also thank Prof. H. Nakayama, Yamaguchi Women's College, for his kind supply ofEscherichia coli 70–17 and 26–43. 相似文献
53.
Ross P Weinhouse H Aloni Y Michaeli D Weinberger-Ohana P Mayer R Braun S de Vroom E van der Marel GA van Boom JH Benziman M 《Nature》1987,325(6101):279-281
Cellulose is the most abundant renewable carbon resource on earth and is an indispensable raw material for the wood, paper, and textile industries. A model system to study the mechanism of cellulose biogenesis is the bacterium Acetobacter xylinum which produces pure cellulose as an extracellular product. It was from this organism that in vitro preparations which possessed high levels of cellulose synthase activity were first obtained in both membranous and soluble forms. We recently demonstrated that this activity is subject to a complex multi-component regulatory system, in which the synthase is directly affected by an unusual cyclic nucleotide activator enzymatically formed from GTP, and indirectly by a Ca (2+) -sensitive phosphodiesterase which degrades the activator. The cellulose synthase activator (CSA) has now been identified as bis-(3' 5')-cyclic diguanylic acid (5'G3'p5'G3'p) on the basis of mass spectroscopic data, nuclear magnetic resonance analysis and comparison with chemically synthesized material. We also report here on intermediary steps in the synthesis and degradation of this novel circular dinucleotide, which have been integrated into a model for the regulation of cellulose synthesis. 相似文献
54.
Mapping of behaviour in Drosophila mosaics 总被引:23,自引:0,他引:23
55.
A. Alkofahi J. K. Rupprecht Y. -M. Liu C. -J. Chang D. L. Smith J. L. McLaughlin 《Cellular and molecular life sciences : CMLS》1990,46(5):539-541
Summary Gigantecin (I), a novel tetrahydroxy-di-tetrahydrofuran fatty acid -lactone (acetogenin), was isolated from an ethanolic extract of the stem bark ofGoniothalamus giganteus Hook. f., Thomas (Annonaceae), by means of activity-directed fractionation (brine shrimp lethality test). This new compound is extremely cytotoxic to human tumor cells, inhibits crown gall tumors on potato discs, and is active in an assay designed to detect antimitotic agents (9 ASK). 相似文献
56.
Summary Metabolism of 26-hydroxycholesterol to 3-hydroxychol-5-en-24-oic acid and other C24-bile acids has been expected to occur by way of 3-hydroxycholest-5-en-26-oic acid in studies in vitro. 3-Hydroxycholest-5-en-26-oic acid was infused intravenously into bile fistula hamsters and the following C24-bile acids were identified: 3-hydroxychol-5-en-24-oic acid, lithocholic acid, chenodeoxycholic acid, and a small amount of cholic acid. 相似文献
57.
Y. Mamiya H. Sonobe K. Yoshida N. Hara Y. Fujimoto 《Cellular and molecular life sciences : CMLS》1995,51(4):363-367
Ecdysteroids in diapause eggs of the silkworm,Bombyx mori, were analyzed using high-performance liquid chromatography (HPLC) combined with radioimmunoassay (RIA). A relatively large amount of an unidentified free ecdysteroid and its phosphoric ester (conjugated form) were detected. These two compounds were isolated by a combination of column chromatography on silicic acid, thin-layer chromatography (TLC), and HPLC using a reverse-phase (RP) column. The purified compounds were identified as 3-epi-22-deoxy-20-hydroxyecdysone (22d20E) and 3-epi-22-deoxy-20-hydroxyecdysone 2-phosphate (22d20E2P) by means of mass spectrometry and nuclear magnetic resonance spectroscopy. to our knowledge, this is the first report of 22d20E and 22d20E2P. 相似文献
58.
用B样条曲线构造几何物体模型的方法 总被引:2,自引:1,他引:1
根据B样条曲线原理,提出了先用若干个截平面去切割几何物体,得到一组与几何物体轮廓线相交的点。根据这些点,再用B样条曲线去构造几何物体的近似轮廓线,从而得到几何物体模型。该方法方便、精确,便于在计算机几何造型系统中应用。 相似文献
59.
加热速度对煤的气化反应性的影响 总被引:2,自引:0,他引:2
实验室条件下考察了五种不同类型的煤经不同加热速度处理后,煤中碳对CO2化学反应性及单位质量碳的气化反应速度常数--特殊反应速度常数的变化规律。研究结果表明:适于直接还原回转窑窑头喷煤用的高挥发分煤,经不同加热速度处理后煤中碳对CO2化学反应性和特殊反应速度常数发生明显变化,随加热速度增大而明显增大,这一研究结果为直接还原回转窑窑头喷煤强化还原的机理研究提供了依据。 相似文献
60.
刘永山 《北京理工大学学报》1998,18(1):47-51
为了更深入地研究引战配合的信息过程,从信息的角度给出引战配合过程的信息描述。方法从信息论的角度将引战配合划分为两个过程:信息传输过程和信息控制过程;给出了可作为引战配合效率的指标,即引战配合过程武器系统所获取的信息量的两种度量方法。 相似文献