Antibody-directed drug discovery

By harnessing the remarkable power of the immune system to access the three-dimensional chemical information sequestered in target sites for drug ligands, antibody-directed drug discovery speeds the design of new therapeutic entities.     

Response to an antiestrogen as a criterion for hormonal sensitivity of endometrial cancer]

A test is described for the evaluation of hormone sensitivity of endometrial cancer in vivo. The concentrations of progesterone and estradiol receptors, and the activities of ornithine-decarboxylase and 17 beta-hydroxysteroid oxido-reductase enzymes have been measured in the tumor, before and after administration of the anti-estrogen tamoxifen. The responses observed, in particular the increase of progesterone receptor, could allow a more rational approach to hormonal therapy of endometrial cancer.     

Immunosuppressive effect of a human serum ferroprotein of hepatic origin, alpha 2 H globulin. Study on blastic transformation of normal lymphocytes in the presence of phytohemagglutinin]

The alpha2 H globulin, a glycoferroprotein, has been found in the serum of patients with malignant diseases. Its level varies according to the evolution of the disease. The activity of this protein has been studied on the normal lymphocytes cultivated in presence of phytohemagglutinin. This study has showed that 5 mug/ml of alpha2 H globulin can inhibit the blastic transformation. The inhibitory effect is proportional to the amount of alpha2 H globulin added as judged by the tritiated thymidin incorporation. The study of morphological aspects of the lymphocytes shows that alpha2 H globulin acts upon the synthesis of the cytoplasmic proteins.     

孤岛油田馆(1+2)地层划分对比与沉积模式

孤岛油田馆(1 2)砂层组属于河流相沉积，其纵向、横向相变迅速，砂体难以大面积追踪，本利用河流结构单元分析法、标准层与辅助标志层控制下的“旋回-厚度”对比法，很好地解决了馆(1 2)地层的划分对比问题，其中馆(1 2)砂层组内辅助标志层的发现为地层的划分对比提供了重要的保证．根据结构单元分析、砂体的岩性特征、粒度特征、河流砂体的空间展布形态以及河流曲率的计算，对馆(1 2)河流沉积的垂向旋回性及沉积模式进行了研究。对比Miall的16种河流分类方案，孤岛油田馆(1 2)砂层组属于细粒曲流河沉积．     

Essai d'interprétation des résultats obtenus récemment chez les Vertébrés sur l'intersexualité hormonale

Sans résuméLaboratoire de zoologie et d'embryologie expérimentale de la Faculté des sciences de Strasbourg.     

Correlation between car ownership and leukaemia: is non-occupational exposure to benzene from petrol and motor vehicle exhaust a causative factor in leukaemia and lymphoma?

Although there is widespread agreement that many cancers have environmental causes we are often unable to see associations between specific cancers and exposure to environmental chemicals. One might also speculate that the more widespread, common-place and 'normal' a chemical exposure is perceived to be then the less likely it will be that the exposure is recognised, let alone be considered to cause cancer. Widespread contamination of air by chemicals associated with internal combustion may be an example of one such 'invisible' carcinogenic exposure. Yet evidence is available which suggests that many leukaemia and lymphoma cases, as well as other cancers, may be caused by this mundane and ubiquitous environmental contamination. The hypothesis is developed that leukaemia 'clustering' as well as national leukaemia incidence may be related to non-occupational exposure to benzene formed by petrol combustion and resulting from petrol evaporation. The possible association between exposure to fuel vapours, internal combustion products and cancer merits much closer examination than it receives at present.     

Circadian-Rhythmik und Gruppenverhalten beiLeucaspius delineatus (Pisces,Cyprinidae)

Summary In constant illumination fish groups and isolated fish exhibit a free running rhythm. The period length of the day active animals decreases with increasing light intensity and vice versa. The results correspond to the circadian rule, the validity of which has proved correct now for fish, too. The synchronization within fish groups is also influenced by socio-ecological factors.     

Multi-lamellar astroglial wrapping of neuronal elements in the hypothalamus of rat

Zusammenfassung In verschiedenen Kerngebieten des Hypothalamus wird eine wechselnde Zahl neuronaler Elemente, wie Somata, Dendriten und verschiedene Synapsentypen, von multilamellären Formationen der Astroglia umhüllt. Diese verstärkte Umhüllung ist hier nicht spezifisch für bestimmte Neuronen- und Synapsentypen, wie in anderen Teilen des ZNS. Vorläufige Ergebnisse am n. supraopticus nach Salzbelastung lassen es als möglich erscheinen, dass die wechselnd starke Bedeckung der neuronalen Elemente durch Astrocytenlamellen vom Aktivitätsniveau der Neurone abhängt.