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Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia 总被引:3,自引:0,他引:3
Pollock PM Cohen-Solal K Sood R Namkoong J Martino JJ Koganti A Zhu H Robbins C Makalowska I Shin SS Marin Y Roberts KG Yudt LM Chen A Cheng J Incao A Pinkett HW Graham CL Dunn K Crespo-Carbone SM Mackason KR Ryan KB Sinsimer D Goydos J Reuhl KR Eckhaus M Meltzer PS Pavan WJ Trent JM Chen S 《Nature genetics》2003,34(1):108-112
77.
Water or ice?--the challenge for invertebrate cold survival 总被引:7,自引:0,他引:7
Block W 《Science progress》2003,86(PT 1-2):77-101
The ecophysiology of cold tolerance in many terrestrial invertebrate animals is based on water and its activity at low temperatures, affecting cell, tissue and whole organism functions. The normal body water content of invertebrates varies from 40 to 90% of their live weight, which is influenced by water in their immediate environment, especially in species with a water vapour permeable cuticle. Water gain from, or loss to, the surrounding atmosphere may affect animal survival, but under sub-zero conditions body water status becomes more critical for overwinter survival in many species. Water content influences the supercooling capacity of many insects and other arthropods. Trehalose is known to maintain membrane integrity during desiccation stress in several taxa. Dehydration affects potential ice nucleators by reducing or masking their activity and a desiccation protection strategy has been detected in some species. When water crystallises to ice in an animal it greatly influences the physiology of nearby cells, even if the cells remain unfrozen. A proportion of body water remains unfrozen in many cold hardened invertebrates when they are frozen, which allows basal metabolism to continue at a low level and aids recovery to normal function when thawing occurs. About 22% of total body water remains unfrozen from calculations using differential scanning calorimetry (compared with ca 19% in food materials). The ratio of unfrozen to frozen water components in insects is 1:4 (1:6 for foods). Such unfrozen water may aid recovery of freezing tolerant species after a freezing exposure. Rapid changes in cold hardiness of some arthropods may be brought about by subtle shifts in body water management. It is recognised that cold tolerance strategies of many invertebrates are related to desiccation resistance, and possibly to mechanisms inherent in insect diapause, but the role of water is fundamental to them all. Detailed experimental studies are needed to provide information which will allow a more complete and coherent understanding of the behaviour of water in biological systems and aid the cryopreservation of a wide range of biological material. 相似文献
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Noise in eukaryotic gene expression 总被引:56,自引:0,他引:56
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Osteoclast differentiation and activation 总被引:134,自引:0,他引:134
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis and activation of bone resorption, and how hormonal signals impact bone structure and mass. Further study of this pathway is providing the molecular basis for developing therapeutics to treat osteoporosis and other diseases of bone loss. 相似文献
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A reinvestigation of the type specimen of Araucarioxylon? obscurum Knowlton (1900) from the Upper Jurassic Morrison Formation in the Freezeout Hills of Wyoming has determined that this fossil should be transferred to Mesembrioxylon Seward (1919) as M. obscurum comb. nov. (Knowlton) Medlyn and Tidwell. Knowlton (1900), who was uncertain of its appropriate generic disposition, tentatively referred the wood to Araucarioxylon because it had obscure growth rings and relatively low ray height. Reexamination of Knowltons slides demonstrates that the wood has uniseriate, rarely biseriate rays, podocarpoid pitting, and diffuse axial parenchyma, none of which Knowlton mentioned. Tracheary pitting is mostly separate, round, uniseriate, occasionally biseriate and, when biseriate, opposite to subopposite. The smooth-walled crossfields exhibit 1-3 thin-bordered podocarpaceous pits per field. All of these features are present in Mesembrioxylon Seward. 相似文献