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41.
J. Bordner D. P. Chakraborty B. K. Chowdhury S. N. Ganguli K. C. Das B. Weinstein 《Cellular and molecular life sciences : CMLS》1972,28(12):1406-1407
Riassunto La struttura del murrayazoline, un'alcoloide carbazole, é stata confermata per via cristallografica con i raggi X. 相似文献
42.
Zusammenfassung 1-Dokosanol, Sesquigoyol,-Sitosterin und 3,5-Dimethoxystilben wurden ausP. formosana isoliert. Es konnte gezeigt werden, dass Sesquigoyol der optische Antipode von (–)--Cadinol ist.
Sesquiterpenoids II. For the previous paper in this series, seeW. G. Dauben, B. Weinstein, P. Lim, andA. B. Anderson, Tetrahedron15, 217 (1961).
On leave of absence from the Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China.
The National Council of Science, Republic of China, is thanked for the award of a fellowship for advanced study to one of us (K.-T.W.). 相似文献
Sesquiterpenoids II. For the previous paper in this series, seeW. G. Dauben, B. Weinstein, P. Lim, andA. B. Anderson, Tetrahedron15, 217 (1961).
On leave of absence from the Department of Chemistry, National Taiwan University, Taipei, Taiwan, Republic of China.
The National Council of Science, Republic of China, is thanked for the award of a fellowship for advanced study to one of us (K.-T.W.). 相似文献
43.
Tumour promotor induces plasminogen activator. 总被引:37,自引:0,他引:37
44.
大叶白麻叶化学成分的研究 总被引:1,自引:0,他引:1
从大叶白麻[poacynumhendersonii(Hookf)woodson]叶中分得2个木脂素类化舍物,经理化常数测定和光谱分析,分别鉴定为(-)-丁香脂素[(-)-Syringaresino1]和( )-松脂素-4-O-β-D-葡萄糖甙[( )-Pinoresionol-4-0-β-D-glucopyranoside]. 相似文献
45.
Yeager M Orr N Hayes RB Jacobs KB Kraft P Wacholder S Minichiello MJ Fearnhead P Yu K Chatterjee N Wang Z Welch R Staats BJ Calle EE Feigelson HS Thun MJ Rodriguez C Albanes D Virtamo J Weinstein S Schumacher FR Giovannucci E Willett WC Cancel-Tassin G Cussenot O Valeri A Andriole GL Gelmann EP Tucker M Gerhard DS Fraumeni JF Hoover R Hunter DJ Chanock SJ Thomas G 《Nature genetics》2007,39(5):645-649
Recently, common variants on human chromosome 8q24 were found to be associated with prostate cancer risk. While conducting a genome-wide association study in the Cancer Genetic Markers of Susceptibility project with 550,000 SNPs in a nested case-control study (1,172 cases and 1,157 controls of European origin), we identified a new association at 8q24 with an independent effect on prostate cancer susceptibility. The most significant signal is 70 kb centromeric to the previously reported SNP, rs1447295, but shows little evidence of linkage disequilibrium with it. A combined analysis with four additional studies (total: 4,296 cases and 4,299 controls) confirms association with prostate cancer for rs6983267 in the centromeric locus (P = 9.42 x 10(-13); heterozygote odds ratio (OR): 1.26, 95% confidence interval (c.i.): 1.13-1.41; homozygote OR: 1.58, 95% c.i.: 1.40-1.78). Each SNP remained significant in a joint analysis after adjusting for the other (rs1447295 P = 1.41 x 10(-11); rs6983267 P = 6.62 x 10(-10)). These observations, combined with compelling evidence for a recombination hotspot between the two markers, indicate the presence of at least two independent loci within 8q24 that contribute to prostate cancer in men of European ancestry. We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%). 相似文献
46.
Thomas G Jacobs KB Yeager M Kraft P Wacholder S Orr N Yu K Chatterjee N Welch R Hutchinson A Crenshaw A Cancel-Tassin G Staats BJ Wang Z Gonzalez-Bosquet J Fang J Deng X Berndt SI Calle EE Feigelson HS Thun MJ Rodriguez C Albanes D Virtamo J Weinstein S Schumacher FR Giovannucci E Willett WC Cussenot O Valeri A Andriole GL Crawford ED Tucker M Gerhard DS Fraumeni JF Hoover R Hayes RB Hunter DJ Chanock SJ 《Nature genetics》2008,40(3):310-315
47.
Jacobs KB Yeager M Zhou W Wacholder S Wang Z Rodriguez-Santiago B Hutchinson A Deng X Liu C Horner MJ Cullen M Epstein CG Burdett L Dean MC Chatterjee N Sampson J Chung CC Kovaks J Gapstur SM Stevens VL Teras LT Gaudet MM Albanes D Weinstein SJ Virtamo J Taylor PR Freedman ND Abnet CC Goldstein AM Hu N Yu K Yuan JM Liao L Ding T Qiao YL Gao YT Koh WP Xiang YB Tang ZZ Fan JH Aldrich MC Amos C Blot WJ Bock CH Gillanders EM Harris CC Haiman CA Henderson BE Kolonel LN Le Marchand L McNeill LH 《Nature genetics》2012,44(6):651-658
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases. 相似文献
48.
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy 总被引:1,自引:0,他引:1
P Koppikar N Bhagwat O Kilpivaara T Manshouri M Adli T Hricik F Liu LM Saunders A Mullally O Abdel-Wahab L Leung A Weinstein S Marubayashi A Goel M Gönen Z Estrov BL Ebert G Chiosis SD Nimer BE Bernstein S Verstovsek RL Levine 《Nature》2012,489(7414):155-159
The identification of somatic activating mutations in JAK2 (refs?1–4) and in the thrombopoietin receptor gene (MPL) in most patients with myeloproliferative neoplasm (MPN) led to the clinical development of JAK2 kinase inhibitors. JAK2 inhibitor therapy improves MPN-associated splenomegaly and systemic symptoms but does not significantly decrease or eliminate the MPN clone in most patients with MPN. We therefore sought to characterize mechanisms by which MPN cells persist despite chronic inhibition of JAK2. Here we show that JAK2 inhibitor persistence is associated with reactivation of JAK–STAT signalling and with heterodimerization between activated JAK2 and JAK1 or TYK2, consistent with activation of JAK2 in trans by other JAK kinases. Further, this phenomenon is reversible: JAK2 inhibitor withdrawal is associated with resensitization to JAK2 kinase inhibitors and with reversible changes in JAK2 expression. We saw increased JAK2 heterodimerization and sustained JAK2 activation in cell lines, in murine models and in patients treated with JAK2 inhibitors. RNA interference and pharmacological studies show that JAK2-inhibitor-persistent cells remain dependent on JAK2 protein expression. Consequently, therapies that result in JAK2 degradation retain efficacy in persistent cells and may provide additional benefit to patients with JAK2-dependent malignancies treated with JAK2 inhibitors. 相似文献
49.
B. Weinstein 《Cellular and molecular life sciences : CMLS》1972,28(12):1517-1522
Résumé La calcitonine, la cholécystokinine, la motilin, la pancreozymine, le peptide inhibiteur gastrique, le peptide vasoactif, la gastrine, le glucagon, et la secretine sont comparables par leur composition en amino acides a l'hormone de croissance, à l'hormone luteinigène, la gonadotropine, au facteur de croissance nerveux, à l'hormone parathyroidienne, au lactogène du placenta, à la proinsuline, à la rénine et à la thyrotropine. Ces peptides proviennent probablement d'un génotype dont l'origine se trouve dans le système digestif. 相似文献
50.