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A peptide isolated from rats habituated to a sound stimulus has been given the structure (see article) Glu-Ala-Gly-Tyr-Ser-Lys-OH. A synthesis of this compound afforded a product that different from the natural material on the basis of chromatographic and physiological comparisons. The proposed sequence must therefore be in error. 相似文献
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Lin Y. -T. Lin K. -T. Wang K. -T. Weinstein B. 《Cellular and molecular life sciences : CMLS》1966,22(3):140-141
Zusammenfassung Es wird die Isolierung eines neuen Nortropolon-Derivates beschrieben.
For the previous paper in this series see: Y.-T.Lin, K.-T.Wang, and B.Weinstein, Chem. Commun., 592 (1965). 相似文献
For the previous paper in this series see: Y.-T.Lin, K.-T.Wang, and B.Weinstein, Chem. Commun., 592 (1965). 相似文献
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Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac 总被引:15,自引:0,他引:15
Max M Shanker YG Huang L Rong M Liu Z Campagne F Weinstein H Damak S Margolskee RF 《Nature genetics》2001,28(1):58-63
The ability to taste the sweetness of carbohydrate-rich foodstuffs has a critical role in the nutritional status of humans. Although several components of bitter transduction pathways have been identified, the receptors and other sweet transduction elements remain unknown. The Sac locus in mouse, mapped to the distal end of chromosome 4 (refs. 7-9), is the major determinant of differences between sweet-sensitive and -insensitive strains of mice in their responsiveness to saccharin, sucrose and other sweeteners. To identify the human Sac locus, we searched for candidate genes within a region of approximately one million base pairs of the sequenced human genome syntenous to the region of Sac in mouse. From this search, we identified a likely candidate: T1R3, a previously unknown G protein-coupled receptor (GPCR) and the only GPCR in this region. Mouse Tas1r3 (encoding T1r3) maps to within 20,000 bp of the marker closest to Sac (ref. 9) and, like human TAS1R3, is expressed selectively in taste receptor cells. By comparing the sequence of Tas1r3 from several independently derived strains of mice, we identified a specific polymorphism that assorts between taster and non-taster strains. According to models of its structure, T1r3 from non-tasters is predicted to have an extra amino-terminal glycosylation site that, if used, would interfere with dimerization. 相似文献
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