排序方式: 共有36条查询结果,搜索用时 0 毫秒
31.
Detlef D. Spalt 《Archive for History of Exact Sciences》1991,42(1):15-70
Ohne Zusammenfassung 相似文献
32.
Elvin SJ Williamson ED Scott JC Smith JN Pérez De Lema G Chilla S Clapham P Pfeffer K Schlöndorff D Luckow B 《Nature》2004,430(6998):417
Mecsas and colleagues suggest that a deficiency in the chemokine receptor CCR5 in humans is unlikely to confer protection against plague, based on their study of Yersinia pestis infection in Ccr5-deficient mice. They were testing the hypothesis that a mutation in the CCR5 gene, frequently found in Caucasians, may have been selected for in the past because it provided protection against (bubonic) plague; the mutation, called CCR5Delta32, is characterized by a 32-base-pair deletion. We have also tested this hypothesis by using Y. pestis infection in mice and, in addition, we have done phagocytosis experiments with macrophages from wild-type and Ccr5-deficient mice. Although, like Mecsas et al., we did not see any difference in the survival of the two groups of mice, we did find that there was a significantly reduced uptake of Y. pestis by Ccr5-deficient macrophages in vitro. Our results indicate that the role of Ccr5 in Y. pestis infection may therefore be more complex than previously thought. 相似文献
33.
Detlef D. Spalt 《Archive for History of Exact Sciences》2002,56(4):285-338
34.
Unger S Böhm D Kaiser FJ Kaulfuss S Borozdin W Buiting K Burfeind P Böhm J Barrionuevo F Craig A Borowski K Keppler-Noreuil K Schmitt-Mechelke T Steiner B Bartholdi D Lemke J Mortier G Sandford R Zabel B Superti-Furga A Kohlhase J 《Nature genetics》2008,40(3):287-289
We identified four girls with a consistent constellation of facial dysmorphism and malformations previously reported in a single mother-daughter pair. Toe syndactyly, telecanthus and anogenital and renal malformations were present in all affected individuals; thus, we propose the name 'STAR syndrome' for this disorder. Using array CGH, qPCR and sequence analysis, we found causative mutations in FAM58A on Xq28 in all affected individuals, suggesting an X-linked dominant inheritance pattern for this recognizable syndrome. 相似文献
35.
Definite values of infinite sums: Aspects of the foundations of infinitesimal analysis around 1820 总被引:3,自引:0,他引:3
Detlef Laugwitz 《Archive for History of Exact Sciences》1989,39(3):195-245
Communicated by
C. Truesdell 相似文献
36.