Anticonvulsant activity of farnesylacetone epoxide--a novel marine natural product.

A marine natural product, farnesylacetone epoxide, which is chemically related to juvenile hormone, has anticonvulsant properties at nonsedative doses in mice.     

Smooth transition exponential smoothing

Adaptive exponential smoothing methods allow a smoothing parameter to change over time, in order to adapt to changes in the characteristics of the time series. However, these methods have tended to produce unstable forecasts and have performed poorly in empirical studies. This paper presents a new adaptive method, which enables a smoothing parameter to be modelled as a logistic function of a user‐specified variable. The approach is analogous to that used to model the time‐varying parameter in smooth transition models. Using simulated data, we show that the new approach has the potential to outperform existing adaptive methods and constant parameter methods when the estimation and evaluation samples both contain a level shift or both contain an outlier. An empirical study, using the monthly time series from the M3‐Competition, gave encouraging results for the new approach. Copyright © 2004 John Wiley & Sons, Ltd.     

A Kind of Systems Methodology——The SPIPRO Principle

This paper deals with the Self-Increasing-Difficulty system (SIDIS) separated from general systems, with emphasis on the relevant methodology based on the Spiral Combining Propulsion Principle (SPIPRO principle in short). The system feature and its causative factors are analysed, and the implications and mechanism of the SPIPRO principle are discussed. Finally, the application possibilities of this methodology are illustrated with some examples.     

A comparative study of proteoglycans from bovine lung,trachea, tracheal mucosa,and aorta

Summary Proteoglycans were isolated from bovine lung, trachea, tracheal mucosa, and aorta by dissociative extraction with 4M guanidinium hydrochloride. Fractionation of these tissue extracts by cesium chloride density centrifugation and gel chromatography allowed the isolation from each extract of a high molecular weight fraction consisting mainly of proteochondroitin sulfate and hyaluronic acid.Acknowledgment. This work was supported by a National Heart, Lung, and Blood Institute grant to K. Ehrlich (HL21617).