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211.
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes 总被引:2,自引:0,他引:2
Skaletsky H Kuroda-Kawaguchi T Minx PJ Cordum HS Hillier L Brown LG Repping S Pyntikova T Ali J Bieri T Chinwalla A Delehaunty A Delehaunty K Du H Fewell G Fulton L Fulton R Graves T Hou SF Latrielle P Leonard S Mardis E Maupin R McPherson J Miner T Nash W Nguyen C Ozersky P Pepin K Rock S Rohlfing T Scott K Schultz B Strong C Tin-Wollam A Yang SP Waterston RH Wilson RK Rozen S Page DC 《Nature》2003,423(6942):825-837
212.
Structure and thermal history of the H-chondrite parent asteroid revealed by thermochronometry 总被引:1,自引:0,他引:1
Trieloff M Jessberger EK Herrwerth I Hopp J Fiéni C Ghélis M Bourot-Denise M Pellas P 《Nature》2003,422(6931):502-506
Our Solar System formed approximately 4.6 billion years ago from the collapse of a dense core inside an interstellar molecular cloud. The subsequent formation of solid bodies took place rapidly. The period of &<10 million years over which planetesimals were assembled can be investigated through the study of meteorites. Although some planetesimals differentiated and formed metallic cores like the larger terrestrial planets, the parent bodies of undifferentiated chondritic meteorites experienced comparatively mild thermal metamorphism that was insufficient to separate metal from silicate. There is debate about the nature of the heat source as well as the structure and cooling history of the parent bodies. Here we report a study of 244Pu fission-track and 40Ar-39Ar thermochronologies of unshocked H chondrites, which are presumed to have a common, single, parent body. We show that, after fast accretion, an internal heating source (most probably 26Al decay) resulted in a layered parent body that cooled relatively undisturbed: rocks in the outer shells reached lower maximum metamorphic temperatures and cooled faster than the more recrystallized and chemically equilibrated rocks from the centre, which needed approximately 160 Myr to reach 390K. 相似文献
213.
The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkB(FL)) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic factor (BDNF) or neurotrophin 4/5 (NT-4/5). By contrast, truncated receptors (TrkB-T1 and TrkB-T2) lack tyrosine kinase activity and have not been reported to elicit rapid intracellular signalling. Here we show that astrocytes predominately express TrkB-T1 and respond to brief application of BDNF by releasing calcium from intracellular stores. The calcium transients are insensitive to the tyrosine kinase blocker K-252a and persist in mutant mice lacking TrkB(FL). By contrast, neurons produce rapid BDNF-evoked signals through TrkB(FL) and the Na(v)1.9 channel. Expression of antisense TrkB messenger RNA strongly reduces BDNF-evoked calcium signals in glia. Thus, our results show that, unexpectedly, TrkB-T1 has a direct signalling role in mediating inositol-1,4,5-trisphosphate-dependent calcium release; in addition, they identify a previously unknown mechanism of neurotrophin action in the brain. 相似文献
214.
Isotopic portrayal of the Earth's upper mantle flow field 总被引:1,自引:0,他引:1
It is now well established that oceanic plates sink into the lower mantle at subduction zones, but the reverse process of replacing lost upper-mantle material is not well constrained. Even whether the return flow is strongly localized as narrow upwellings or more broadly distributed remains uncertain. Here we show that the distribution of long-lived radiogenic isotopes along the world's mid-ocean ridges can be used to map geochemical domains, which reflect contrasting refilling modes of the upper mantle. New hafnium isotopic data along the Southwest Indian Ridge delineate a sharp transition between an Indian province with a strong lower-mantle isotopic flavour and a South Atlantic province contaminated by advection of upper-mantle material beneath the lithospheric roots of the Archaean African craton. The upper mantle of both domains appears to be refilled through the seismically defined anomaly underlying South Africa and the Afar plume. Because of the viscous drag exerted by the continental keels, refilling of the upper mantle in the Atlantic and Indian domains appears to be slow and confined to localized upwellings. By contrast, in the unencumbered Pacific domain, upwellings seem comparatively much wider and more rapid. 相似文献
215.
Chen NJ Mirtsos C Suh D Lu YC Lin WJ McKerlie C Lee T Baribault H Tian H Yeh WC 《Nature》2007,446(7132):203-207
Complement-derived anaphylatoxins regulate immune and inflammatory responses through G-protein-coupled receptor (GPCR)-mediated signalling. C5L2 (also known as GPR77) is a relatively new GPCR thought to be a non-signalling receptor binding to C5a, on the basis of sequence information and experimental evidence. Here we show, using gene targeting, that C5L2 is required to facilitate C5a signalling in neutrophils, macrophages and fibroblasts in vitro. Deficiency of C5L2 results in reduced inflammatory cell infiltration, suggesting that C5L2 is critical for optimal C5a-mediated cell infiltration in certain in vivo settings. C5L2 is also involved in optimizing C3a-induced signals. Furthermore, like mice incapable of C3a/complement 3a receptor (C3aR) signalling, C5L2-deficient mice are hypersensitive to lipopolysaccharide (LPS)-induced septic shock, show reduced ovalbumin (OVA)-induced airway hyper-responsiveness and inflammation, and are mildly delayed in haematopoietic cell regeneration after gamma-irradiation. Our data indicate that C5L2 can function as a positive modulator for both C5a- and C3a-anaphylatoxin-induced responses. 相似文献