全文获取类型
收费全文 | 1006篇 |
免费 | 2篇 |
国内免费 | 2篇 |
专业分类
系统科学 | 13篇 |
理论与方法论 | 5篇 |
现状及发展 | 259篇 |
研究方法 | 100篇 |
综合类 | 567篇 |
自然研究 | 66篇 |
出版年
2018年 | 4篇 |
2016年 | 4篇 |
2014年 | 3篇 |
2013年 | 8篇 |
2012年 | 31篇 |
2011年 | 98篇 |
2010年 | 6篇 |
2008年 | 39篇 |
2007年 | 37篇 |
2006年 | 36篇 |
2005年 | 37篇 |
2004年 | 34篇 |
2003年 | 31篇 |
2002年 | 34篇 |
2001年 | 20篇 |
2000年 | 44篇 |
1999年 | 16篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1992年 | 18篇 |
1991年 | 10篇 |
1990年 | 19篇 |
1989年 | 15篇 |
1988年 | 12篇 |
1987年 | 14篇 |
1986年 | 19篇 |
1985年 | 12篇 |
1984年 | 13篇 |
1983年 | 12篇 |
1982年 | 6篇 |
1981年 | 9篇 |
1980年 | 10篇 |
1979年 | 16篇 |
1978年 | 19篇 |
1977年 | 20篇 |
1976年 | 15篇 |
1975年 | 20篇 |
1974年 | 23篇 |
1973年 | 17篇 |
1972年 | 20篇 |
1971年 | 31篇 |
1970年 | 44篇 |
1969年 | 15篇 |
1968年 | 27篇 |
1967年 | 26篇 |
1966年 | 22篇 |
1965年 | 10篇 |
1964年 | 8篇 |
1963年 | 2篇 |
1961年 | 2篇 |
排序方式: 共有1010条查询结果,搜索用时 62 毫秒
141.
142.
The weather factor in foot and mouth disease epidemics 总被引:1,自引:0,他引:1
143.
144.
The Proteus swarming phenomenon 总被引:1,自引:0,他引:1
D G Smith 《Science progress》1972,60(240):487-506
145.
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function 总被引:27,自引:0,他引:27
Reiser J Polu KR Möller CC Kenlan P Altintas MM Wei C Faul C Herbert S Villegas I Avila-Casado C McGee M Sugimoto H Brown D Kalluri R Mundel P Smith PL Clapham DE Pollak MR 《Nature genetics》2005,37(7):739-744
Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability barrier in the kidney. Mutations in genes encoding structural proteins of the podocyte lead to the development of proteinuria, resulting in progressive kidney failure and focal segmental glomerulosclerosis. Here, we show that the canonical transient receptor potential 6 (TRPC6) ion channel is expressed in podocytes and is a component of the glomerular slit diaphragm. We identified five families with autosomal dominant focal segmental glomerulosclerosis in which disease segregated with mutations in the gene TRPC6 on chromosome 11q. Two of the TRPC6 mutants had increased current amplitudes. These data show that TRPC6 channel activity at the slit diaphragm is essential for proper regulation of podocyte structure and function. 相似文献
146.
147.
148.
Vitamin B12 (cobalamin) was identified nearly 80 years ago as the anti-pernicious anaemia factor in liver, and its importance in human health and disease has resulted in much work on its uptake, cellular transport and utilization. Plants do not contain cobalamin because they have no cobalamin-dependent enzymes. Deficiencies are therefore common in strict vegetarians, and in the elderly, who are susceptible to an autoimmune disorder that prevents its efficient uptake. In contrast, many algae are rich in vitamin B12, with some species, such as Porphyra yezoensis (Nori), containing as much cobalamin as liver. Despite this, the role of the cofactor in algal metabolism remains unknown, as does the source of the vitamin for these organisms. A survey of 326 algal species revealed that 171 species require exogenous vitamin B12 for growth, implying that more than half of the algal kingdom are cobalamin auxotrophs. Here we show that the role of vitamin B12 in algal metabolism is primarily as a cofactor for vitamin B12-dependent methionine synthase, and that cobalamin auxotrophy has arisen numerous times throughout evolution, probably owing to the loss of the vitamin B12-independent form of the enzyme. The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis. 相似文献
149.
150.
Zusammenfassung Es wird über die Totalsynthese von verschiedenen Derivaten des (±)-6-Oxa- und Aza-Östrons und die Umwandlung von (±)-17-Oxy-3-methoxy-6-oxa-östratrien-1, 3, 510 zu Verbindungen der (±)-19-Nor-6-oxa-testosteron-Klasse berichtet. Die biologische Wirksamkeit der Glieder in der 6-Oxa-Reihe wird beschrieben. 相似文献