Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease.

Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional growth factor that has profound regulatory effects on many developmental and physiological processes. Disruption of the TGF-beta 1 gene by homologous recombination in murine embryonic stem cells enables mice to be generated that carry the disrupted allele. Animals homozygous for the mutated TGF-beta 1 allele show no gross developmental abnormalities, but about 20 days after birth they succumb to a wasting syndrome accompanied by a multifocal, mixed inflammatory cell response and tissue necrosis, leading to organ failure and death. TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions.     

双脉冲TEA CO_2激光器电路参数的选择

分析了电路参数及电路结构对双脉冲TEA CO_2激光器输出稳定性的影响,并提出合理选择电路参数与结构的原则。实验结果,证实了分析的正确性。     

非公有制经济参与西部大开发若干问题的研究

我国经济发展机制的重要变化是非公有制经济迅速成长壮大,并以其特有的活力与生机成为经济发展的新的增长空间。注重和加强非公有制经济参与西部大开发的问题研究,对促进以国有经济为主导的西部地区经济高速发展,具有重要的理论意义和实际意义,并能为政府关于区域和西部开发的发展战略提供参考依据。     

Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis.

The fragile-X syndrome is the most frequent inherited form of mental retardation, with an incidence of 1 in 1,500 males. It is characterized by the presence of a fragile site at Xq27.3 induced in vitro by folate deprivation or by inhibitors of deoxynucleotide synthesis. Its mode of inheritance is unusual for an X-linked trait, with incomplete penetrance in both males and females. Some phenotypically normal males transmit the mutation to all their daughters who rarely express any symptoms, but penetrance is high in sons and daughters of these carrier women. Genetic and physical mapping of the Xq27-q28 region has confirmed that the disease locus is located at or very near the fragile site. Hypotheses proposed to account for the abnormalities in the inheritance of the disease include sequence rearrangements by meiotic recombination or a mutation that affects reactivation of an inactive X chromosome during differentiation of female germ cells. To detect such rearrangements, or methylation changes that may reflect a locally inactive X chromosome, we used pulsed-field gel analysis of DNA from fragile-X patients with probes close to the fragile-X locus. The probe Do33 (DXS465) detected abnormal patterns in fragile-X patients, but not in normal controls or in non-expressing male transmitters.     

谈化工原理课如何进行德育渗透

结合化工原理课程内容及教学方法，在讲授专业知识的同时，注重培养学生的职业创造能力，并使他们掌握科学的学习方法、养成良好的行为习惯，能适应快速发展的化工行业新需要。     

二十八天水泥抗压强度动态模型及参数对预测的影响

本文用时间序列分析方法分析水泥生产过程,笔者假设水泥生产过程为一个平稳的随机过程,它的二十八天抗压强度为具有控制项的自回归模型。用30组数据建立了28天水泥抗压强度动态模型,并做了跟踪,分析了七天抗压强度、细度、SO_3等与二十八天抗压强度的关系。最后,把生产中实际值和预测值进行了比较。     

设备诊断专家系统的层次诊断模型

本文在讨论复杂机电系统故障特征之后,提出了诊断专家系统的层次诊断模型.该模型以对象系统的结构分级为基础,使用作者提出的征兆分析法、功能分析法和综合信号分析法等三种具体诊断方法,得到了分层适应诊断的层次诊断模型.最后介绍了以层次诊断模型为基础的汽车发动机诊断专家系统的概况.     

用测量模态阻尼和振型的方法对复合材料薄平板进行无损质量检测

复合材料薄平板经热压制成后,都需要进行质量检测。本文探索用测量模态阻尼和振型的方法,对复合材料薄平板的制作质量进行无损检测,作为对其它昂贵的无损检测方法的补充。略述用振动方法进行无损检测的原理,测量薄平板阻尼的方法以及提高测量精度的措施。还讨论在测量薄平板阻尼时可能遇到的一些特殊问题(如非线性刚度、拍、模态密集等问题);以云母基复合材料薄平板作为例子,从测量其阻尼和振型的结果,对这种板的制作质量进行讨论。     

多任务操作系统在嵌入式系统开发中的应用

通过对嵌入式系统软件开发中的两种编程思路的分析比较,说明了采用多任务操作系统进行程序开发的优势和必要,并简要分析了RTX51多任务操作系统.最后,结合一个实际课题,论证了多任务操作系统在嵌入式系统开发中的应用.     

曲棍球赛场技战术的计算机分析系统

介绍在ＩＢＭ－ＰＣ／ＸＴ计算机上实现的曲棍球赛场统计系统的研制过程、设计思想、采用的方法、软件设计与功能、技术指标操作步骤以及使用效果。