2000-based national population projections for the United Kingdom and its constituent countries

The 2000-based national population projections, carried out by the Government Actuary at the request of the Registrars General, show the population of the United Kingdom rising from 59.8 million in 2000 to nearly 65 million by 2025. Longer-term projections suggest the population will peak at nearly 66 million around 2040 and then gradually start to fall. The population will become gradually older with the median age expected to rise from 37.4 years in 2000 to 42.4 years by 2025. In 2000, there were 1.3 million (12 per cent) more children aged under 16, than people of state pensionable age. However, by 2007, the population of state pensionable age is projected to exceed the number of children.     

多相滤波器组的ZFFT算法在轨道电路信号检测中的应用

针对轨道电路信号(FSK信号)的检测提出了基于多相滤波器组的频谱细化(ZFFT)分析方法,该方法利用多相滤波器组将待分析的移频信号按照不同载频分解成多个子带,经过子带选择,再进行FFT,与传统的信号检测算法相比,这种算法可以提高信号检测精度和实时性.     

A Systemic Exploration of Lesotho’s Basic Education through Interactive Management

Lesotho is an inland country striving to improve its economy. Accessible education is perceived as an effective approach to economic growth. Over the years, various projects were commenced to improve Lesotho’s basic education provision. However, the progress is not satisfactory or stable. This paper argues for systemic thinking and adopts Warfield’s interactive management to identify the difficulties in Lesotho’s education projects. Interactive management can help stakeholders to identify system elements, structure the relationship between systems elements and produce a diagraph representing the system in question. The core mechanism of interactive management is a binary matrix which can infer the existence of a relationship between system elements, provided that the relationship is transitive. Four root problems were identified through the interactive management process: ‘board members not educated’, ‘poor service delivery by the Ministry of Education and Training to teachers’, ‘food insecurity’ and ‘reduced and standardisation of school fees at post primary schools’. The developed model demonstrates how system elements are interconnected. The model has potential to be used as a starting point for the Lesotho government to manage on its basic education problems through the identified root causes.     

Assumptions for the 2000-based national population projections

This article summarises the long-term assumptions of fertility, mortality and net migration which will underlie the forthcoming 2000-based national population projections. Compared with the current (1998-based) projections, the new projections will assume lower levels of fertility, but higher levels of inward net migration. There will be relatively little change to mortality assumptions. Results of the new projections will be available on 15 November 2001.     

Rendering Grass Blowing in the Wind with Global Illumination

We have simulated a time varying wind field using the lattice Boltzmann model, and its effect on blades of grass with a simple mass-spring model. We present a global illumination model for multiple scattering of incident sun and sky illumination within the field of grass. We model the grass as a continuous distribution of infinitesimal colored scattering flakes and solve a system of differential equations for the radiance transport. We repeat this for a collection of grass bending directions and amounts, an...     

Emission-Based Scatter Correction in SPECT Imaging

Scatter correction in single photon emission computed tomography(SPECT) has been focused on either using multiple-window acquisition technique or the scatter modeling technique in iterative image reconstruction.We propose a technique that uses only the emission data for scatter correction in SPECT.We assume that the scatter data can be approximated by convolving the primary data with a scatter kernel followed by the normalization using the scatter-to-primary ratio(SPR).Since the emission data is the superpo...     

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins that modulate biological function by initiating cellular signalling in response to chemically diverse agonists. Despite recent progress in the structural biology of GPCRs, the molecular basis for agonist binding and allosteric modulation of these proteins is poorly understood. Structural knowledge of agonist-bound states is essential for deciphering the mechanism of receptor activation, and for structure-guided design and optimization of ligands. However, the crystallization of agonist-bound GPCRs has been hampered by modest affinities and rapid off-rates of available agonists. Using the inactive structure of the human β(2) adrenergic receptor (β(2)AR) as a guide, we designed a β(2)AR agonist that can be covalently tethered to a specific site on the receptor through a disulphide bond. The covalent β(2)AR-agonist complex forms efficiently, and is capable of activating a heterotrimeric G protein. We crystallized a covalent agonist-bound β(2)AR-T4L fusion protein in lipid bilayers through the use of the lipidic mesophase method, and determined its structure at 3.5?? resolution. A comparison to the inactive structure and an antibody-stabilized active structure (companion paper) shows how binding events at both the extracellular and intracellular surfaces are required to stabilize an active conformation of the receptor. The structures are in agreement with long-timescale (up to 30?μs) molecular dynamics simulations showing that an agonist-bound active conformation spontaneously relaxes to an inactive-like conformation in the absence of a G protein or stabilizing antibody.     

Specific targeting of cytotoxic T cells by anti-T3 linked to anti-target cell antibody

The specificity of cytotoxic T lymphocytes (Tc) cells is conferred by an antigen-specific receptor, Ti, which in humans is physically associated with an invariant cell-surface glycoprotein, T3. Monoclonal antibodies specific for either T3 and Ti are able to elicit a variety of T-cell responses such as lymphokine production, mitogenesis and cytotoxicity. For example, human Tc cells lyse anti-T3-expressing hybridoma cells, but not cells of other specificity, presumably because anti-T3 on the hybridoma cells binds to T3 on the Tc cells and triggers lysis. Here, we have adapted approaches used in a different cytotoxic effector system, antibody-dependent cellular cytotoxicity (ADCC), to alter the specificity of Tc cell. Studies of ADCC showed that heteroaggregates containing anti-Fc receptor (Fc gamma R) antibody cross-linked to a second antibody bind to Fc gamma R on ADCC effectors and cause them to kill target cells bearing antigen recognized by the second antibody. The present studies use anti-T3-containing heteroaggregates to re-target human Tc cells to cells for which we have appropriate antibodies, including xenogeneic tumour cells and chicken erythrocytes. These results extend previous observations on the role of T3 in triggering cytotoxicity and suggest that effector cell re-targeting could be used for in vivo treatment of neoplasms and other pathogens that express distinctive surface antigens.     

Stress response genes protect against lethal effects of sleep deprivation in Drosophila

Sleep is controlled by two processes: a homeostatic drive that increases during waking and dissipates during sleep, and a circadian pacemaker that controls its timing. Although these two systems can operate independently, recent studies indicate a more intimate relationship. To study the interaction between homeostatic and circadian processes in Drosophila, we examined homeostasis in the canonical loss-of-function clock mutants period (per(01)), timeless (tim(01)), clock (Clk(jrk)) and cycle (cyc(01)). cyc(01) mutants showed a disproportionately large sleep rebound and died after 10 hours of sleep deprivation, although they were more resistant than other clock mutants to various stressors. Unlike other clock mutants, cyc(01) flies showed a reduced expression of heat-shock genes after sleep loss. However, activating heat-shock genes before sleep deprivation rescued cyc(01) flies from its lethal effects. Consistent with the protective effect of heat-shock genes, was the observation that flies carrying a mutation for the heat-shock protein Hsp83 (Hsp83(08445)) showed exaggerated homeostatic response and died after sleep deprivation. These data represent the first step in identifying the molecular mechanisms that constitute the sleep homeostat.