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21.
肾移植后伴骨质疏松症患者血清骨代谢指标的变化 总被引:2,自引:1,他引:2
应用放射免疫分析法和免疫放射分析法对7例已确诊有骨质疏松症的骨移植患者进行血清骨代谢指标检测。结果表明患者成骨细胞活性指标(血清特异性骨碱怀磷酸酶、骨钙素和I型前胶原蛋白羧基末端前肽)和破骨细胞功能指标(血清I型胶原交联羧基末端肽)明显高于正常对照组,患者血清甲状旁腺素和25羟维生素D水平正常。提示肾移植后伴骨质疏松症患者的成骨细胞活性和破骨细胞活性明显增高,但无继发性甲状旁腺功能亢进和维生素D代 相似文献
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E. Schumacher 《Cellular and molecular life sciences : CMLS》1957,13(3):104-105
Summary Measurements of the radiogenic87Sr/87Rb ratio of the chondritic meteorite Forest City are discussed in the light of a new determination of the half-life of87Rb. Earlier conclusions are confirmed. 相似文献
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Cichon S Buervenich S Kirov G Akula N Dimitrova A Green E Schumacher J Klopp N Becker T Ohlraun S Schulze TG Tullius M Gross MM Jones L Krastev S Nikolov I Hamshere M Jones I Czerski PM Leszczynska-Rodziewicz A Kapelski P Bogaert AV Illig T Hauser J Maier W Berrettini W Byerley W Coryell W Gershon ES Kelsoe JR McInnis MG Murphy DL Nurnberger JI Reich T Scheftner W O'Donovan MC Propping P Owen MJ Rietschel M Nöthen MM McMahon FJ Craddock N 《Nature genetics》2004,36(8):783-4; author reply 784-5
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Christian Schumacher 《Journal of forecasting》2007,26(4):271-302
This paper discusses the forecasting performance of alternative factor models based on a large panel of quarterly time series for the German economy. One model extracts factors by static principal components analysis; the second model is based on dynamic principal components obtained using frequency domain methods; the third model is based on subspace algorithms for state‐space models. Out‐of‐sample forecasts show that the forecast errors of the factor models are on average smaller than the errors of a simple autoregressive benchmark model. Among the factor models, the dynamic principal component model and the subspace factor model outperform the static factor model in most cases in terms of mean‐squared forecast error. However, the forecast performance depends crucially on the choice of appropriate information criteria for the auxiliary parameters of the models. In the case of misspecification, rankings of forecast performance can change severely. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
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Northcott PA Shih DJ Peacock J Garzia L Morrissy AS Zichner T Stütz AM Korshunov A Reimand J Schumacher SE Beroukhim R Ellison DW Marshall CR Lionel AC Mack S Dubuc A Yao Y Ramaswamy V Luu B Rolider A Cavalli FM Wang X Remke M Wu X Chiu RY Chu A Chuah E Corbett RD Hoad GR Jackman SD Li Y Lo A Mungall KL Nip KM Qian JQ Raymond AG Thiessen NT Varhol RJ Birol I Moore RA Mungall AJ Holt R Kawauchi D Roussel MF Kool M Jones DT Witt H Fernandez-L A Kenney AM Wechsler-Reya RJ Dirks P Aviv T 《Nature》2012,488(7409):49-56
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive chemotherapy. As medulloblastoma exhibits marked intertumoural heterogeneity, with at least four distinct molecular variants, previous attempts to identify targets for therapy have been underpowered because of small samples sizes. Here we report somatic copy number aberrations (SCNAs) in 1,087 unique medulloblastomas. SCNAs are common in medulloblastoma, and are predominantly subgroup-enriched. The most common region of focal copy number gain is a tandem duplication of SNCAIP, a gene associated with Parkinson's disease, which is exquisitely restricted to Group 4α. Recurrent translocations of PVT1, including PVT1-MYC and PVT1-NDRG1, that arise through chromothripsis are restricted to Group 3. Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy. 相似文献
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Empty MHC class I molecules come out in the cold 总被引:43,自引:0,他引:43
H G Ljunggren N J Stam C Ohlén J J Neefjes P H?glund M T Heemels J Bastin T N Schumacher A Townsend K K?rre 《Nature》1990,346(6283):476-480
Major histocompatibility complex (MHC) class I molecules present antigen by transporting peptides from intracellularly degraded proteins to the cell surface for scrutiny by cytotoxic T cells. Recent work suggests that peptide binding may be required for efficient assembly and intracellular transport of MHC class I molecules, but it is not clear whether class I molecules can ever assemble in the absence of peptide. We report here that culture of the murine lymphoma mutant cell line RMA-S at reduced temperature (19-33 degrees C) promotes assembly, and results in a high level of cell surface expression of H-2/beta 2-microglobulin complexes that do not present endogenous antigens, and are labile at 37 degrees C. They can be stabilized at 37 degrees C by exposure to specific peptides known to interact with H-2Kb or Db. Our findings suggest that, in the absence of peptides, class I molecules can assemble but are unstable at body temperature. The induction of such molecules at reduced temperature opens new ways to analyse the nature of MHC class I peptide interactions at the cell surface. 相似文献
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M. T. R. Subbiah M. C. Naylor J. Schumacher B. A. Kottke 《Cellular and molecular life sciences : CMLS》1974,30(3):249-250
Zusammenfassung Nachweis, dass die 5-Reduktion von [14C]Cholesterol homogenisierter Fäces durch Milch, Laktose und Galaktose gehemmt wurde, wobei die Hemmung unspezifisch war und auch mit anderen Zuckern erzielt werden konnte. 相似文献
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Kote-Jarai Z Olama AA Giles GG Severi G Schleutker J Weischer M Campa D Riboli E Key T Gronberg H Hunter DJ Kraft P Thun MJ Ingles S Chanock S Albanes D Hayes RB Neal DE Hamdy FC Donovan JL Pharoah P Schumacher F Henderson BE Stanford JL Ostrander EA Sorensen KD Dörk T Andriole G Dickinson JL Cybulski C Lubinski J Spurdle A Clements JA Chambers S Aitken J Gardiner RA Thibodeau SN Schaid D John EM Maier C Vogel W Cooney KA Park JY Cannon-Albright L Brenner H Habuchi T Zhang HW Lu YJ Kaneva R 《Nature genetics》2011,43(8):785-791
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 × 10(-8) to P = 2.7 × 10(-24)). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified. 相似文献