影响锚喷支护巷道质量因素的探讨

光面爆破是锚喷支护的根本条件，是保证锚喷质量的基础性工作，喷浆是锚喷支护的外在表现，直接影响着锚喷支护的效果。只要在这两方面下功夫，同时对诸多小因素进行规范管理，井巷锚喷支护质量一定会得到提高。     

C-terminal domain of Chk1 regulates its subcellular location and kinase activity for DNA repair

Effector kinase Chk1 is an evolutionarily conserved protein kinase. It is a key mediator linking the mechanisms that monitor DNA integrity to components of the cell cycle engine. In this study, recombinant vectors pEGFP-C1-Chk1/C 288/C 334/C 368 were constructed and transfected into HeLa cells to study the effect of the Chk1 regulatory domain on the regulation of subcellular Chk1 location in response to DNA damage. We found that DNA damage-induced nuclear accumulation is regulated by 34 amino acids (334–368) in the C-terminal regulatory domain. Recombinant vectors pXJ41-Chk1/C 288/C 334/C 368 were co-transfected with reporter plasmid pEGFP-N2 into HeLa cells to study the repair abilities of the different human Chk1 truncation mutants. In addition, recombinant vectors were transfected into HeLa cells to study the effects of the different truncation mutants on the cell cycle. Furthermore, to study the kinase activity of the different truncation mutants, Ser216 phosphorylation of Cdc25C was studied by Western blot analysis. We found that the enzymatic activity of C 368, missing the 108 C-terminal amino acids (368–476), was higher than that of full-length Chk1, and C 368 delayed the cell cycle progression. The enzymatic activity of C 334, missing the 142 C-terminal amino acids (334–476), was equivalent to that of full-length Chk1. C 288, missing the 188 C-terminal amino acids (288–476), had almost no enzymatic activity, suggesting that the regulatory domain contains both inhibitory and regulatory elements. This study provides useful information for further research on Chk1 function.     

一类含潜伏时滞的SIS传染病模型的定性研究

利用构造Liapunov泛函的方法,研究了一类含有潜伏期时滞的SIS传染病模型.得到了地方病平衡点和无病平衡点局部及全局渐近稳定的充分条件;当时滞超过某一临界值时,地方病平衡点失去稳定性,通过Hopf分支在其附近跳出极限环.揭示了时滞对疾病传播的影响.     

Kallikrein-like activity in the urine of renal hypertensive rats

Résumé La ligature «en figure huit» d'un rein suivie de l'ablation de l'organ contrelatéral, est accompagnée d'une remarquable amoindrissement de l'activité kallikreine urinaire pourvu que les animaux développent une pression artérielle permanente et élevée.     

Functional corticotropin releasing factor receptors in the primate peripheral sympathetic nervous system

Corticotropin releasing factor (CRF) is a key hormone in the integrated response to stress, acting both as the major regulator of pituitary adrenocorticotropic hormone (ACTH) release and as a neuropeptide in the brain. The actions of CRF are mediated by specific plasma membrane receptors in the anterior pituitary gland and in discrete brain areas including the cerebral cortex and several regions related to the limbic system. In addition to the pituitary and central actions of CRF, systemic administration of the peptide in the rat, dog, monkey and man causes hypotension and tachycardia because of a decrease in peripheral vascular resistance. These observations, in conjunction with the finding of immunoreactive and bioactive CRF in peripheral tissues, suggest that the peptide is locally released in tissues to act as a neurotransmitter or paracrine hormone. As CRF is present in the adrenal medulla and the peptide is known to modulate the central activity of the autonomic nervous system, we investigated the possibility that CRF is involved in the regulation of the peripheral autonomic nervous system. Such an action of CRF is supported by our demonstration of specific CRF receptors in the monkey adrenal medulla and sympathetic ganglia. In the adrenal medulla, these receptors are coupled to adenylate cyclase and can stimulate the secretion of catecholamines and Met-enkephalin.     

快速热退火对a-Si:H/SiO2多层膜光致发光的影响

采用在等离子体增强化学气相沉积(PFCVD)系统中沉积a-Si：H和原位等离子体逐层氧化的方法制备a-Si：H／SO2多层膜．用快速热退火对a-Si：H／SiO2多层膜进行处理，制备nc—Si/SiO2多层膜，研究了这种方法对a-Si：H／SiO2多层膜发光特性的影响．研究发现对a-Si：H／SiO2多层膜作快速热退火处理，可获得位于绿光和红光两个波段的发光峰．研究了不同退火条件下发光峰的变化．通过对样品的TEM、Raman散射谱和红外吸收谱的分析，探讨了a-Si：H／SiO2多层膜在不同退火温度下的光致发光机理．     

计算机多媒体技术在教学中的应用

论述了《道路交通事故处理》课的特点以及计算机多媒体技术在《道路交通事故处理》教学中的应用。     

两种术式治疗膀胱颈挛缩的疗效观察

目的针对膀胱颈挛缩采用膀胱颈后唇楔切除术或后唇楔切除术加Y-V成形术与经尿道膀胱颈电切术的治疗并进行疗效对比。方法对33例耻骨上经膀胱前列腺摘除术后膀胱颈挛缩患者资料进行回顾性分析，1996年2月。2005年2月收治33例62岁以上膀胱颈挛缩患者，其中A组（行膀胱颈后唇楔形切除术）19例，B组（经尿道膀胱颈电切术）14例，年龄、术前全身状况均相似，并随访3-15月。结果B组平均住院日及手术持续时间均较短，且出血量少，并发症发生率低。随访3～15月，A组症状改善率为73.7％，B组为92.9％。结论经尿道膀胱颈电切术（TuRN）治疗耻骨上经膀胱前列腺摘除术后膀胱颈挛缩，其梗阻解除彻底，创伤小，出血少，并发症少，恢复快，是一种较理想的治疗方法。     

ICP—AES法测定铬铁中的硅、锰、磷

本文叙述了用等离子体发射光谱法同时测定铬铁中硅、锰、磷的方法。试样经湿法处理后,通过系列试验,选择仪器合适的工作条件,进行测定,方法回收率在97-105%之间,相对标准偏差均小于5%。经对照分析,结果令人满意。本方法和传统方法相比,快速准确,精密度高。     

基于卫星影像的土地变更调查关键技术研究——变更调查与卫片执法工作的结合

土地卫片执法检查是指通过卫星遥感监测、地理信息解译等高新技术对一个年度土地利用变化情况进行监测、监督检查的过程.自卫片执法结合到土地变更调查工作中实施以来,违法用地呈逐步减少趋势,但是土地变更工作与卫片执法工作结合方面仍然存在问题.为提高二者工作协调的效率,以重庆市北碚区为研究区域对此进行了研究,对于存在的时点和B/W定义两方面的问题,变更调查工作须与其相协调,特别是在工作标准、工作时间方面相协调、一致,并有针对性地提出了一些策略和建议.