W1607俯斜沿空综采面的瓦斯治理及防灭火技术

新集二矿针对W1607俯斜沿空综采工作面瓦斯涌出的特点,分析了工作面上隅角的瓦斯来源,对综采工作面设施了合理配风、均压通风、本煤层瓦斯抽放、顶板走向钻孔抽放及顶板高抽巷抽放瓦斯的综合治理及防火措施,确保了高产高效俯斜沿空综采工作面的安全生产。     

De novo cardiomyocytes from within the activated adult heart after injury

A significant bottleneck in cardiovascular regenerative medicine is the identification of a viable source of stem/progenitor cells that could contribute new muscle after ischaemic heart disease and acute myocardial infarction. A therapeutic ideal--relative to cell transplantation--would be to stimulate a resident source, thus avoiding the caveats of limited graft survival, restricted homing to the site of injury and host immune rejection. Here we demonstrate in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction. We reveal a novel genetic label of the activated adult progenitors via re-expression of a key embryonic epicardial gene, Wilm's tumour 1 (Wt1), through priming by thymosin β4, a peptide previously shown to restore vascular potential to adult epicardium-derived progenitor cells with injury. Cumulative evidence indicates an epicardial origin of the progenitor population, and embryonic reprogramming results in the mobilization of this population and concomitant differentiation to give rise to de novo cardiomyocytes. Cell transplantation confirmed a progenitor source and chromosome painting of labelled donor cells revealed transdifferentiation to a myocyte fate in the absence of cell fusion. Derived cardiomyocytes are shown here to structurally and functionally integrate with resident muscle; as such, stimulation of this adult progenitor pool represents a significant step towards resident-cell-based therapy in human ischaemic heart disease.     

The role of forecasting in corporate strategy: The xerox experience

This paper presents the system of analysis used by the Xerox Corporation to relate the external environment to company decisions. The system is sophisticated and elaborate, comes to grips with such issues as product forecasting, market monitoring, activity monitoring, materials and labour cost analysis, and product price analysis. In addition, the system examines the longer-term issues associated with corporate strategy, with the more recent initiatives directed toward the strategic focus The Xerox case illustrates very well how externally provided forecasts of economic environments, both at home and abroad, can be used as inputs to a variety of econometric products to serve the individual corporation. The challenge in this work is to build the bridges from the external forces to the critical company decisions. That is a task which requires sophisticated tools and skilled professionals to accomplish. This case study shows what can be done.