The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. Using genome-wide synthetic genetic array mapping, we identified multiple TIF6 gain-of-function alleles that suppressed the pre-60S nuclear export defects and cytoplasmic mislocalization of Tif6 observed in sdo1Delta cells. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes. Thus, our data link defective late 60S ribosomal subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.     

动脉粥样硬化病因新说:肺炎衣原体感染

动脉粥样硬化所致的心、脑血管疾病的发病率和死亡率均居各种疾病前列,其确切病因尚不明确.目前公认的最重要的危险因子是高血脂、高血压、吸烟及糖尿病.然而,肺炎衣原体可能是动脉粥样硬化的潜在致病病原体.众多的血清流行病学研究、动物模型、细胞及分子水平的研究和抗生素干预临床试验都提示肺炎衣原体与动脉粥样硬化及其相关疾病(如冠心病)密切关联.肺炎衣原体作为动脉粥样硬化病因及其致病机制的阐明将为公共卫生学与临床医学领域的发展翻开新的一页.     

一种基于导弹地面试验台的对心调节机构设计与研究

针对导弹地面试验台中需要很多对心安装工作,如迷宫内外套对心安装等,存在安装过程复杂,调整困难,安装时间长,定位精度较差等问题。以迷宫内外套对心安装为例,通过非标结构选型和加工,设计了一套对心调节机构,通过现场安装对比,得出新型对心调节机构具有定位精度高、操作简单方便、大大节约工作时长、调节迅速且简便等优点。该新型对心调节机构,对导弹地面试验台其他需要对心调整的工作,同样具有简单、高效、节约成本的作用,它的设计与研究有很高的工程实践意义。     

不同环境温度下的织物芯输送带压陷滚动阻力仿真研究

随着带式输送机绿色节能要求的提高,如何有效减小压陷滚动阻力成为重要课题。为研究环境温度对带式输送机压陷滚动阻力的影响规律,并克服实际工程数据检测难这一困难,提出了一种围绕环境温度的有限元仿真方法。以织物芯带式输送机为研究对象,通过SolidWorks建立三维模型,之后利用ANSYS Workbench有限元分析软件开展在不同环境温度下的压陷滚动阻力仿真研究,其中使用Mooney-Rivlin的两参数模型定义输送带覆盖层材料。结果表明,环境温度的升高使得压陷滚动阻力逐渐减小。研究结果为带式输送机绿色节能提供了依据。     

LBHF型电液执行机构的通电锁位功能改造

本文从分析锦州石化分公司三催化车间一起闪电事故入手,分析了采用SA-4B型放大器的LBHF型电液执行机构在事故发生时不锁位的原因,并对其进行了改造,使其成为真正的事故安全型电液执行机构。     

汽车电子机械制动器的效能分析

为了分析电子机械制动器（electmmechanical bloking,简称EMB）的制动效能,建立了电子机械制动器的数学模型和在水平路面上汽车制动时整车动力学模型,运用MATLAB／SIMULINK仿真软件对电子机械制动器和液压制动器（hydmulic braking简称HB）的制动性能进行了比较．结果表明：电子机械制动器的制动效能明显优于传统的液压制动器,为电子机械制动器工程开发提供了理论依据.     

烟支硬度检测结果影响因素分析

为探究烟支硬度检测结果的影响因素,对烟支物理指标检测方案进行优化,提升卷烟质量监督水平.本试验以3类卷烟泰山(东方)为试验材料,分别设计不同检测方案、挡烟板位置、预压时间、压缩时间、压缩速度、环境湿度、贮存时间来对烟支硬度进行测定.烟支检测全项时硬度明显高于单独检测出的硬度;随挡烟板位置的增加,烟支硬度检测值先下降再上...     

An organic junction between the vein and membrane of the dragonfly wing

A dragonfly wing consists of membranes and both longitudinal and cross veins. We observed the microstructure cross-section at several locations in the dragonfly wing using environmental scanning electron microscopy (ESEM). The organic nature of the junction between the vein and the membrane was clearly identifiable. The membrane was divided into two layers, the upper epidermis and the lower epidermis. These layers extend around the sandwich structure vein, and combine with the adjacent membrane at a symmetrical location along the vein. Thus, we defined this as an organic junction between the vein and the membranes. The organic junction is able to form a tight corrugation angle, which dramatically increases both the warping rigidity and the strength of the wing, but not the torsional rigidity. The torsional deformation is primarily controlled by the microstructure of the longitudinal veins, and is based on the relative rotation angle between the epidermal layer and the inner layer of the vein that forms the zigzag section.     

Identification of AtSM34, a novel tonoplast intrinsic protein-interacting polypeptide expressed in response to osmotic stress in germinating seedlings

Aquaporins are implicated in a wide variety of plant physiological processes, although the mechanisms involved in their regulation are not fully understood. To gain further insight into the regulatory factors involved in this process, we used a yeast two-hybrid system to screen for potential binding partners to the Arabidopsis tonoplast intrinsic protein (TIP) AtTIP1;1. This was the first protein identified to be associated with high water permeability in vacuolar membranes from Arabidopsis thaliana. Using ...     

轻质聚合物干粉抹面砂浆抗压强度与抗冻性

外墙抹面砂浆作为建筑物外表层常年受到冻害侵扰,为有效缓解冻害破坏及厘清劣化机理。以空心漂珠作细集料,掺入聚合物干粉与重钙制备不同水灰比的轻质抹面砂浆,通过正交试验,揭示水灰比、可再分散乳胶粉掺量及重钙掺量对抗压强度和抗冻性能的影响规律,并探讨砂浆性能变化的微观机理。结果表明：水灰比对抗压强度影响显著,可再分散乳胶粉掺量次之,重钙掺量影响最小。对于抗冻性能可再分散乳胶粉掺量影响显著,重钙掺量影响最小;在不同养护龄期下,水灰比对抗压强度影响较大,可再分散乳胶粉掺量对抗冻性能影响较大。若将水灰比控制在0.35附近,可再分散乳胶粉掺量与重钙掺量保持在3%以内,虽然抗压强度小幅降低,但抗冻性能优异。综合考虑抗压强度和抗冻性能的实际需求,外墙抹面砂浆的抗冻性能重要程度远大于抗压强度,基于此,可确定干粉抹灰的最优配比为水灰比0.37、可再分散乳胶粉掺量2.8%、重钙掺量3.9%。此外,也可结合实际工作环境与工程要求,设计不同配比的干粉抹灰。