Differential alterations in branched-chain amino acid decarboxylation in liver of hypophysectomized rats

Summary Valine decarboxylation was significantly increased and leucine decarboxylation was significantly decreased in rat liver slices following hypophysectomy. In both normal and hypophysectomized rats decarboxylation of leucine exceeded that of valine in slices whereas the reverse was observed with the respective keto acids and mitochondria.Acknowledgments. This study was supported by the National Institutes of Health and the Samuel A. Berger Foundation.     

Taurine concentrations in the aqueous humor and plasma of anesthetized rabbits

Summary Aqueous humor taurine concentrations were found to be significantly higher (p<0.01) than that of the plasma in anesthetized rabbits. Topical application of 2 mg terbutaline lowered intraocular pressure (p<0.001), but did not alter aqueous taurine content.Supported by National Eye Institute grants Nos EY05430 (JMR) and EY02156 (DEP).Acknowledgments. We thank Dr J. Gintautas, this institution, for translating reference 18 and Dr S. Y. Schmidt, Massachusetts Eye and Ear Infirmary, for valuable advice.     

Clumps and streams in the local dark matter distribution

In cold dark matter cosmological models, structures form and grow through the merging of smaller units. Numerical simulations have shown that such merging is incomplete; the inner cores of haloes survive and orbit as 'subhaloes' within their hosts. Here we report a simulation that resolves such substructure even in the very inner regions of the Galactic halo. We find hundreds of very concentrated dark matter clumps surviving near the solar circle, as well as numerous cold streams. The simulation also reveals the fractal nature of dark matter clustering: isolated haloes and subhaloes contain the same relative amount of substructure and both have cusped inner density profiles. The inner mass and phase-space densities of subhaloes match those of recently discovered faint, dark-matter-dominated dwarf satellite galaxies, and the overall amount of substructure can explain the anomalous flux ratios seen in strong gravitational lenses. Subhaloes boost gamma-ray production from dark matter annihilation by factors of 4 to 15 relative to smooth galactic models. Local cosmic ray production is also enhanced, typically by a factor of 1.4 but by a factor of more than 10 in one per cent of locations lying sufficiently close to a large subhalo. (These estimates assume that the gravitational effects of baryons on dark matter substructure are small.).