Observation of the ideal Josephson effect in superfluid 4He

Superfluids and superconductors are the only states of condensed matter that can be described by a single wavefunction, with a coherent quantum phase Phi. The mass flow in a superfluid can be described by classical hydrodynamics for small flow velocity, but above a critical velocity, quantized vortices are created and the classical picture breaks down. This can be observed for a superfluid flowing through a microscopic aperture when the mass flow is measured as a function of the phase difference across the aperture; the curve resembles a hysteretic sawtooth where each jump corresponds to the creation of a vortex. When the aperture is made small enough, the system can enter the so-called 'ideal' Josephson regime, where the superfluid mass flow becomes a continuous function of the phase difference. This regime has been detected in superfluid 3He, but was hitherto believed to be unobservable, owing to fluctuations, in 4He. Here we report the observation of the ideal Josephson effect in 4He. We study the flow of 4He through an array of micro-apertures and observe a transition to the ideal Josephson regime as the temperature is increased towards the superfluid transition temperature, Tlambda.     

Warm tropical sea surface temperatures in the Late Cretaceous and Eocene epochs

Climate models with increased levels of carbon dioxide predict that global warming causes heating in the tropics, but investigations of ancient climates based on palaeodata have generally indicated cool tropical temperatures during supposed greenhouse episodes. For example, in the Late Cretaceous and Eocene epochs there is abundant geological evidence for warm, mostly ice-free poles, but tropical sea surface temperatures are generally estimated to be only 15-23 degrees C, based on oxygen isotope palaeothermometry of surface-dwelling planktonic foraminifer shells. Here we question the validity of most such data on the grounds of poor preservation and diagenetic alteration. We present new data from exceptionally well preserved foraminifer shells extracted from impermeable clay-rich sediments, which indicate that for the intervals studied, tropical sea surface temperatures were at least 28-32 degrees C. These warm temperatures are more in line with our understanding of the geographical distributions of temperature-sensitive fossil organisms and the results of climate models with increased CO2 levels.     

Quantification of Ca2+-activated K+ channels under hormonal control in pig pancreas acinar cells

Ca2+- and voltage-activated K+ channels are found in many electrically excitable cells and have an important role in regulating electrical activity. Recently, the large K+ channel has been found in the baso-lateral plasma membranes of salivary gland acinar cells, where it may be important in the regulation of salt transport. Using patch-clamp methods to record single-channel currents from excised fragments of baso-lateral acinar cell membranes in combination with current recordings from isolated single acinar cells and two- and three-cell clusters, we have now for the first time characterized the K+ channels quantitatively. In pig pancreatic acini there are 25-60 K+ channels per cell with a maximal single channel conductance of about 200 pS. We have quantified the relationship between internal ionized Ca2+ concentration [( Ca2+]i) membrane potential and open-state probability (p) of the K+ channel. By comparing curves obtained from excised patches relating membrane potential to p, at different levels of [Ca2+]i, with similar curves obtained from intact cells, [Ca2+]i in resting acinar cells was found to be between 10(-8) and 10(-7) M. In microelectrode experiments acetylcholine (ACh), gastrin-cholecystokinin (CCK) as well as bombesin peptides evoked Ca2+-dependent opening of the K+ conductance pathway, resulting in membrane hyperpolarization. The large K+ channel, which is under strict dual control by internal Ca2+ and voltage, may provide a crucial link between hormone-evoked increase in internal Ca2+ concentration and the resulting NaCl-rich fluid secretion.     

The effect of theophylline on the actions of Pancreozymin and Secretin

Résumé Chez le chat, l'injection intravéneuse de théo phylline qui, comme on sait, produit une accumulation de l'AMP cyclique, augmente aussi l'effet de la pancréozymine sur la production des protéines pancréatiques et de la sécrétine sur celle de la pepsine.

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This work was supported by Grant No. MA3093 from the Medical Research Council of Canada to Dr. J. C.Brown.