AGC板厚控制系统中对时滞非线性问题的有效控制方法

针对在AGC板厚控制系统中存在时滞、时变、大惯性、非线性等问题，提出了采用，自适应集中延时神经网络辨识、最优预报和模糊免疫PID控制相结合的控制方案，有效地提高了系统的控制精度和动态性能。经MATLAB仿真实验表明，各项指标均好于传统的控制方式，取得了令人满意的控制效果。     

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque

Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions associated with the presence of carotid plaque (P < 5 × 10(-8)). The associated SNPs mapped in or near genes related to cellular signaling, lipid metabolism and blood pressure homeostasis, and two of the regions were associated with coronary artery disease (P < 0.006) in the Coronary Artery Disease Genome-Wide Replication and Meta-Analysis (CARDIoGRAM) consortium. Our findings may provide new insight into pathways leading to subclinical atherosclerosis and subsequent cardiovascular events.     

一阶电路冲激响应的广义函数解释

首先说明作为广义函数的单位冲激函数,其次阐述激励在电路中的作用及特点,然后通过计算当作为激励时一阶RC电路和一阶RL电路的响应,从而介绍一种求解一阶电路单位冲激响应的新思路,最后阐述信号处理知识的实用性。     

欧式期权波动率校准反问题的正则化算法

标的资产的隐含波动率校准问题无论在理论上还是实际应用中都有重要意义.对于欧式期权,在Black-Scholes模型框架下,提出了一个正则化的最小二乘算法,有效地解决了在期权市场价格已知前提下的隐含波动率校准反问题.最后,通过数值算例说明了方法的有效性.     

红透山矿区三维地质建模与可视化研究

红透山矿区是中国开采深度最深的金属矿山之一,具有巨大的找矿潜力。本文采用三维地质建模和可视化技术方法,结合红透山矿区地质特征,以国际矿业软件Surpac为平台,建立红透山矿区地质数据库,在此基础上构建了矿区地表、断层、矿体以及地层三维实体模型。为提取地质控矿指标,基于地质体三维实体模型,通过地质空间立体单元划分,建立了岩性、断层、矿化分布等控矿因素的三维空间场模型,以及可控源音频大地电磁法CSAMT、瞬变电磁法TEM物探找矿指标三维空间场模型,直观显示了矿区地质体空间分布特征,为进一步开展红透山矿区深边部三维定量找矿预测奠定了基础。研究表明,三维可视化建模技术在隐伏矿体立体定量预测研究中具有明显优势,具有较高的推广和应用价值。     

盾构机刀盘驱动控制系统的设计与应用

介绍了以PLC做控制器、工控机做监控器、S120为执行器,构成刀盘的驱动控制系统。进而在盾构机刀盘驱动性能的要求下,设计出刀盘驱动控制系统,阐述了主从控制方式,实现主从传动的负荷均衡分配功能,保证机械受力的均匀和一致性。从而实现设备的安全、可靠运行。     

电力企业安全性评价动态管理特性解析

阐述了安全性评价(SES)的含义及发展概况,说明安全性评价工作是对电力企业安全生产行之有效的管理方法,指出了准确理解和把握安全性评价的动态管理特性,是安全性评价工作有效实施和管理优化的重要前提;分析了安全性评价的动态管理特性必然存在的原因;提出了电力企业在安全性评价工作实施过程中应实行以人为本的管理,持续完善和更新安全性评价工作的评价内容和标准,实行全过程闭环动态管理,注重推动安全性评价的优化与发展。     

Physical Characteristics of Knitted Polyester Vascular Prostheses： Can the Wall Be Considered as a Scaffold for Tissue Regeneration？

Recent developments in endovascular surgery (EVAR) have opened new avenues to successfully treat aneurysms with percutaneous deployment of stent-grafts.Manufacturers have preferred to use woven fabrics or micro-porous tubes which are supported by metallic frames or stents.Woven fabrics are much thinner than knits and this permits the use of a smaller delivery catheter.However,since woven constructions are stiffer and have little porosity,the tissue ingrowth is poor or absent.On the other hand,knitted constructions can be considered as a scaffold for tissue ingrowth,and hence they represent an attractive alternative because of their open structure and better conformability in the case of balloon deployment.The present study was undertaken to analyze the properties of two knitted and crimped polyester arterial prototype prostheses,one with and the other without a gelatin coating as sealant.Two commercial controls were also included in the study,namely the uncoated knitted polyester vascular prosthesis VP1200K,and its sealed version,the gelatin coated polyester knitted Gelsoft device,manufactured by Vascutek Ltd.,Scotland,UK.In vitro testing consisted of analyzing the geometry and morphology of the yarn and fabric structures,and measuring the physical and mechanical properties of the grafts,including the water permeability,the longitudinal and radial compliance,and the suture retention strength.In order to compare the different properties of the four samples,tests were also performed on the gelatin coated or sealed devices before and after gelatin removal.The results provided a useful comparison between the prototypes and the commercial control devices.The latter used ten times the amount of gelatin which had been applied as a coating in order to achieve the same low level of impermeability to water.The different amounts of gelatin also explained the different mechanical performance,such as compliance,for these prototype and control prostheses.     

Mutations in the skeletal muscle alpha-actin gene in patients with actin myopathy and nemaline myopathy.

Muscle contraction results from the force generated between the thin filament protein actin and the thick filament protein myosin, which causes the thick and thin muscle filaments to slide past each other. There are skeletal muscle, cardiac muscle, smooth muscle and non-muscle isoforms of both actin and myosin. Inherited diseases in humans have been associated with defects in cardiac actin (dilated cardiomyopathy and hypertrophic cardiomyopathy), cardiac myosin (hypertrophic cardiomyopathy) and non-muscle myosin (deafness). Here we report that mutations in the human skeletal muscle alpha-actin gene (ACTA1) are associated with two different muscle diseases, 'congenital myopathy with excess of thin myofilaments' (actin myopathy) and nemaline myopathy. Both diseases are characterized by structural abnormalities of the muscle fibres and variable degrees of muscle weakness. We have identified 15 different missense mutations resulting in 14 different amino acid changes. The missense mutations in ACTA1 are distributed throughout all six coding exons, and some involve known functional domains of actin. Approximately half of the patients died within their first year, but two female patients have survived into their thirties and have children. We identified dominant mutations in all but 1 of 14 families, with the missense mutations being single and heterozygous. The only family showing dominant inheritance comprised a 33-year-old affected mother and her two affected and two unaffected children. In another family, the clinically unaffected father is a somatic mosaic for the mutation seen in both of his affected children. We identified recessive mutations in one family in which the two affected siblings had heterozygous mutations in two different exons, one paternally and the other maternally inherited. We also identified de novo mutations in seven sporadic probands for which it was possible to analyse parental DNA.     

动力学分区余能变分原理及其广义变分原理

本文首先指出．在动力学余能变分原理中，只要给出满足起始和终了时刻速度的假定，则不再需要满足其他任何附加的约束条件，在此基础上．本文提出并论证了动力学分区余能变分原理，并利用拉格朗日乘子法得到了不完全和完全的动力学分区广义余能变分原理．