The London evening courses of Benjamin Martin and James Ferguson,eighteenth-century lecturers on experimental philosophy

A study of some London newspapers of the early 1770s has shown that Martin and Ferguson gave continuous courses of evening lectures during the winter, in direct competition with each other. In this paper the coverage of their courses is derived from their advertisements, and related to their publications and other activities. In some subjects, such as Electricity, Hydrostatics, and Air-pump Experiments, there was close correspondence between the courses, but others reflected the lecturers' primary interests: for Martin, Optics, and for Ferguson, Mechanics and Astronomy.     

Properties and causes: An approach to the problem of hypothesis in the scientific methodology of Sir Isaac Newton

This article considers the differential absorption and integration of refugee physicists into various countries during the 1930s, and the social and intellectual factors responsible for this, focusing particularly on the social functions of the British and American university at that period, as well as continuing ideological struggles in the Soviet Union. More generally, the issue of the relative absorption of refugee physicists is used to examine the nature of the physics communities and other institutions of the host societies.     

Epigenesis in Kant: Recent reconsiderations

Epigenesis has become a far more exciting issue in Kant studies recently, especially with the publication of Jennifer Mensch's Kant’ Organicism. In my commentary, I propose to clarify my own position on epigenesis relative to that of Mensch and others by once again considering the discourse of epigenesis in the wider eighteenth century. Historically, I maintain that Kant was never fully an epigenesist because he feared its materialist implications. This makes it highly unlikely that he drew heavily, as other interpreters like Dupont and Huneman have suggested, on Caspar Friedrich Wolff for his ultimate theory of “generic preformation.” In order to situate more precisely what Kant made of epigenesis, I distinguish his metaphysical use, as elaborated by Mensch, from his view of it as a theory for life science. In that light, I raise questions about the scope and authority of philosophy vis a vis natural science.     

United Kingdom: The Corporate Strategy for 1989 of the Medical Research Council (MRC)

Science Policy News

United Kingdom: The Corporate Strategy for 1989 of the Medical Research Council (MRC)     

Common nonsynonymous variants in PCSK1 confer risk of obesity

Mutations in PCSK1 cause monogenic obesity. To assess the contribution of PCSK1 to polygenic obesity risk, we genotyped tag SNPs in a total of 13,659 individuals of European ancestry from eight independent case-control or family-based cohorts. The nonsynonymous variants rs6232, encoding N221D, and rs6234-rs6235, encoding the Q665E-S690T pair, were consistently associated with obesity in adults and children (P = 7.27 x 10(-8) and P = 2.31 x 10(-12), respectively). Functional analysis showed a significant impairment of the N221D-mutant PC1/3 protein catalytic activity.     

Nematodes and the spleen: An immunological relationship

Despite being a major organ of the immune system, the spleen's role in resisting, controlling or simply ameliorating nematode infections has been neglected. A review of both filarial and gastrointestinal nematodes suggests that though it is difficult to fully assess or quantify the organ's importance in vivo, the spleen is prominent in acting against nematode parasites in mammals. One manifestation of this is that transfer of lymphocytes from the spleen of immunised individuals can protect recipients against the disease. Expansion of splenic lymphoid tissue also alludes to its activity during nematode infection. There is a considerable need for investigation of the spleen under natural conditions as well as much more rigorously controlled experiments even in mammals besides birds and other vertebrates.     

Quasi-rational expectations: Experimental evidence

The theory of quasi-rational expectations was tested under the controlled conditions of the economics laboratory. Five experiments were conducted with a variety of stochastic processes. In each experiment, subjects produced one-step-ahead forecasts of the variable generated by a Monte Carlo process. Comparisons of the performance of an aggregate of subjects' forecasts versus an ARIMA model showed that for relatively simple series (such as those generated by autoregressive processes of first or second order) the aggregate forecast was indistinguishable from that of the model. These results lend support to the theory that forecasts from an ARIMA model can serve as substitutes for aggregate expectations in macroeconomic policy models under some conditions.     

Simultaneous equation estimates of electricity demand for the rural south: Revenue projection when prices are administered

Presented are estimates of demand equations and producer revenue projections for rural farm electricity consumers in the USA. Statistical tests include a Box-Cox comparison of functional form, a Koyck-distributed lag, and a contrast of average versus marginal prices. Producer revenue projections take account of the estimated demand equation and non-continuous rate schedules for each of the electricity distributors. Multiple price equilibria result from differences in administered price schedules between sellers. The ‘effective’ price elasticity based upon forecasts which take account of the market circumstances is lower than the simple demand point elasticity but higher than found in some previous studies.