Adenosine-induced slow ionic currents in the Xenopus oocyte

Adenosine and its 5'-phosphorylated congeners evoke specific membrane-mediated responses in excitable tissues. Available data suggest that inhibition of the target cell occurs due to hyperpolarization, and in some preparations a compound effect of ATP (excitation and inhibition) has been found. However, the ionic mechanism of the purinergic-mediated response has not been studied by standard intracellular voltage-clamping techniques. Recently, we have discovered purinergic receptors in the Xenopus oocyte, a well defined giant cell amenable to rigorous electrophysiological and biochemical studies. We report here that in these cells, adenosine-induced slow membrane responses consisted of an early depolarizing (D) transient current carried by Cl ions, followed by a steady hyperpolarizing (H) current involving K+ ions. The relative potency sequence for the D current was ATP congruent to ADP greater than AMP congruent to adenosine; this order was reversed for the H current.     

Effect of chemical sympathectomy,adrenalectomy and adrenergicα- andβ-blocking agents on the development of hyperglycemia induced by streptozotocin in the rat

Summary The sympathetic nervous system in the rat does not play any significant role in the streptozotocin-induced and tolbutamipe-induced hypoglycemia.     

Phospholipid composition ofDipylidium caninum

Summary The phospholipid composition ofDipylidium caninum has been studied. Chloroform-methanol-soluble fraction amounted to 2.4% and phospholipids to 0.5% of the wet weight of the parasite. Phosphatidyl choline and phosphatidyl ethanolamine represented the bulk of the phospholipids, whereas phosphatidyl serine, phosphatidyl inositol, lysolecithin and lysophosphatidyl ethanolamine were present in minor amounts. Sulfatides were also identified in this parasite.     

Shock effects on plants: Tannic acid and chlorogenic acid in yam roots

Résumé Les tanins de l'acide chlorogénique s'accumulent immédiatement après que les racines d'ignames ont été soumises à des chocs de 10 à 44 (0.6–2.66 kg/cm²), consistant en une pulsation de la pression comparable à une rafale d'air dans un tube. L'accumulation des tanins est inversement proportionelle à la pression. Mais, l'acide chlorogénique s'accumule progressivement avec élèvation du niveau du choc.     

Improvement of the thermoregulation efficiency of man above 1500 m altitude

Zusammenfassung Nachweis, dass vor allem atmosphärische Abkühlungsfaktoren Asthmaanfälle auslösen können und dass der menschliche Organismus über einer kritischen Höhe von 1500 m gegen solche Temperaturreize weniger empfindlich ist. Permanente Besserung nach wiederholter Höhenbehandlung.     

Variability of the bohr effect in man

Riassunto L'effetto Bohr è notevolmente e significativamente più elevato nei diabetici che negli individui normali. Si dimostra che tale differenza non è dovuta ad un cambiamento nella molecola dell'emoglobina, ma alla presenza di un cofattore diverso da quelli noti e cioé dai fosfati organici ATP e 2–3 DPG.     

The regulatory role of phosphodiesterase in adenosine cyclic 3′,5′-monophosphate mediated ACTH action

Résumé Le désoxycholate de soude inhibe fortement l'activité de la phosphodiestérase surrénalienne du rat. Par contre, l'administration de l'ACTH in vivo augmente cette activité en présence du déoxycholate. In vitro, chez le rat traité préalablement par le l'ACTH, cette activité est moins inhibée par le désoxycholate dans la fraction particulière comme dans la fraction surnageante. L'action de l'ACTH joue donc un rôle régulateur de la phosphodiestérase.