河北省区域经济发展水平的差异研究

从经济规模、经济效益、经济结构、生活质量和经济潜力5方面构建评价指标体系并建立了计量模型,对河北省11个地级市的经济水平进行了评价,结果表明区域经济差异十分显著,并将11个地区分为3个层次。之后找到影响区域经济差异的主要因素——区位、经济基础、行政及资源,最后提出了一些促进区域经济协调发展的建议。     

公共交通实时控制模型研究

研究了实时控制模型 ,即对照中途站行车时刻表与车辆实际到达本站的时间 ,对车辆实施控制 ,保证线路的行车间隔和各车辆的载客量均匀正常 .论文重点讨论了实时调度的控制模型 ,然后给出了实例进行说明.     

公交优先的信号控制策略研究

研究了公交优先信号控制策略,模拟路边建立公交车辆检测器的情况下,不同交通流量和公交车发车间隔的最优控制策略,研究发现：当交通流量小于300辆／h．车道时,公交优先信号控制策略能显著地减少乘客的延误时间,而当交通流量达到500辆／h．车道时,即使有公交优先控制策略,而无公交专用道路,也不能有效减少乘客的延误时间,模拟实验的结果是：找到了使公交优先信号控制有效的交通流量和公交车发车间隔的阈值。     

现代商业照明的产品设计初探

从现代商业照明的界定、特征、种类、产品现状等几个方面进行了阐述,进而探讨了现代商业照明对产品开发设计的要求,并进一步归结成现代商业照明的产品设计理念,最后指出了商业照明产品设计理念上的发展方向以及现代商业照明的产品发展趋势.现代商业照明的产品设计突破传统,简洁合理,动感美观,经典浪漫,前卫个性彰显,强调文化内涵,融合不同风格,追求品质灯具设计,营造健康光环境.     

可持续发展对工业设计教育的启示

从工业设计学科的角度出发,以可持续发展与工业设计之间的关系入手,结合当今我国工业设计教育的现状,着重探讨了如何将可持续的概念延伸到设计教育中去,发展可持续性的、综合性的工业设计教育,并就工业设计教育与传统文化、设计教育与社会的可持续发展等方面的问题做了一个简要的论述.     

Nanoparticle-based drug delivery: case studies for cancer and cardiovascular applications

Nanoparticles (NPs) comprised of nanoengineered complexes are providing new opportunities for enabling targeted delivery of a range of therapeutics and combinations. A range of functionalities can be included within a nanoparticle complex, including surface chemistry that allows attachment of cell-specific ligands for targeted delivery, surface coatings to increase circulation times for enhanced bioavailability, specific materials on the surface or in the nanoparticle core that enable storage of a therapeutic cargo until the target site is reached, and materials sensitive to local or remote actuation cues that allow controlled delivery of therapeutics to the target cells. However, despite the potential benefits of NPs as smart drug delivery and diagnostic systems, much research is still required to evaluate potential toxicity issues related to the chemical properties of NP materials, as well as their size and shape. The need to validate each NP for safety and efficacy with each therapeutic compound or combination of therapeutics is an enormous challenge, which forces industry to focus mainly on those nanoparticle materials where data on safety and efficacy already exists, i.e., predominantly polymer NPs. However, the enhanced functionality affordable by inclusion of metallic materials as part of nanoengineered particles provides a wealth of new opportunity for innovation and new, more effective, and safer therapeutics for applications such as cancer and cardiovascular diseases, which require selective targeting of the therapeutic to maximize effectiveness while avoiding adverse effects on non-target tissues.     

Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event

Streptococcus pneumoniae ('pneumococcus') causes an estimated 14.5 million cases of serious disease and 826,000 deaths annually in children under 5 years of age(1). The highly effective introduction of the PCV7 pneumococcal vaccine in 2000 in the United States(2,3) provided an unprecedented opportunity to investigate the response of an important pathogen to widespread, vaccine-induced selective pressure. Here, we use array-based sequencing of 62 isolates from a US national monitoring program to study five independent instances of vaccine escape recombination(4), showing the simultaneous transfer of multiple and often large (up to at least 44 kb) DNA fragments. We show that one such new strain quickly became established, spreading from east to west across the United States. These observations clarify the roles of recombination and selection in the population genomics of pneumococcus and provide proof of principle of the considerable value of combining genomic and epidemiological information in the surveillance and enhanced understanding of infectious diseases.