Spécificité de l'action antiphage de substances synthétiques

Summary The effect of synthetic antiphages has been studied against different types of bacteriophage in the same bacterium, in this caseEscherichia coli. Most substances are active only against typesT ₁, 3, 5, 7 (and our type 207) but not against types 2, 4, 6. Others show activity only against type 1 (and our type 207). The antiphage activity of a substance therefore seems to depend upon a specific relationship between its chemical structure and that of the phage type against which it is active.     

Esterase alterations in the liver of dystrophic mice

Zusammenfassung Esterase-Isozym-Verluste wurden in Leberzymogrammen von Mäusen mit hereditärer Muskeldystrophie gefunden.

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On leave of absence from the Department of Physiology, Wakayama Medical College, Wakayama, Japan.     

Cholesterin und Fettsäuren als Ersatz von Serum in der Kultur vonTrichomonas foetus

Summary In the presence of a minimal amount of a water-soluble growth factor from bovine serum, cholesterol together with an unsaturated fatty acid may replace the ethersoluble lipoid fraction of the same serum. The concentration of cholesterol and fatty acid, as well as the chemical structure of the latter, are relevant.     

Antiallergische Wirkung bakterieller Polysaccharide

Summary It is shown that certain bacterial polysaccharides possess marked antianaphylactic properties. These hitherto unknown effects, which are not due to a change in sensitivity to histamine, result from a complex and peculiar mechanism of action.     

Vergleichende Untersuchungen über die hypertensive Wirkung von Aldosteron und Desoxycorticosteron

Summary In the adrenalectomized and unilaterally nephrectomized rat an investigation has been carried out on the influence of a four weeks' treatment with aldosterone and desoxycorticosterone-acetate in doses which are equieffective concerning sodium retaining capacity. Desoxycorticosterone-acetate produced hypertension, perivascular granuloma and renal lesions, whereas under the influence of aldosterone the blood pressure remained normal and no histopathological alterations could be found. Towards the end of the experiment the animals treated with desoxycorticosterone-acetate took up twice as much drinking fluid as the animals treated with aldosterone. Although the results obtained so far are only of a preliminary character it is obvious that aldosterone in doses which are equieffective concerning sodium retention does not produce the same side effects as desoxycorticosterone-acetate.     

Reduction of body fat stores by inhibition of prolactin secretion

Reductions of prolactin secretion by bromocriptine treatment for 24 days reduced fat stores (abdominal and epididymal fat depots) in hamsters by 25-49% compared with control animals. However, body weights and food consumption were not affected. These results further substantiate an important role for prolactin in regulation of fat metabolism and indicate that bromocriptine might be used to decrease fat stores.     

5种不同遗传背景绿色荧光蛋白(GFP)基因导入系小鼠的培育

通过反复回交——筛选目的基因的手段,将C57BL/6-Tg(UBC-GFP)30Scha/J转基因小鼠的绿色荧光蛋白基因(GFP)分别向BABL/C、CBA/J、DBA/2J、AKR/J、FVB/J等品系小鼠导入,得到了5种不同遗传背景且带有GFP基因的导入系小鼠.冰冻组织切片等方法显示GFP导入系小鼠的皮肤、肝、肾、心、肺等均有不同程度的绿色荧光蛋白表达,不同遗传背景对GFP的组织表达谱、血液生理指标及繁殖性能未见影响.本实验采用基因导入法培育了5种新的带有GFP导入系小鼠,这些不同遗传背景的基因导入系小鼠为移植生物学研究提供了材料.     

The muscle spindle in mice with hereditary neuromuscular diseases

Zusammenfassung Der Aussendiameter der Muskelspindeln variert in Mäusen von Muskel zu Muskel. Der Grössenunterschied ist altersunabhängig. In Mäusen mit vererblichen neuromuskulären Erkrankungen wurden nur geringe Abnormitäten der Spindeln gefunden. Anscheinend sind sie erkrankungsresistent oder entwickeln sich erst im späteren Erkrankungsprozess.