Wirkung von Polysacchariden bakterieller Herkunft auf die experimentelle Lipämie

Summary Polysaccharide fractions derived from a gram-negative proteus organism show strong anti-lipaemic activity of the order of 1000 times that of heparin. Analogous preparations from gram-positive organisms and mycobacteria show no such activity and some polysaccharide fractions from plant and animal tissues proved to have slight activity. None of these polysaccharides influenced the clotting of plasmain vitro.     

Some physico-chemical properties of mouse red cells and hemoglobin

Zusammenfassung Hämoglobin und Erythrozyten von prä- und postnatal untersuchten Inzuchtmäusen verhalten sich, was verschiedene physikalisch-chemische Analysen betrifft, ähnlich. Die Existenz eines fötalen Hämoglobins konnte nicht bewiesen werden.

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This investigation was supported by a grant from the National Institutes of Health, P.H.S. C-4691.     

Ein chemisch und pharmakologisch neuartiger Antagonist von pathophysiologisch bedeutsamen Aminen,Kininen und kininbildenden Faktoren

Summary CIBA 21 401-Ba, a glucofuranoside derivative (ethyl-3,5,6-O-benzyl-d-glucofuranoside), antagonizes in vitro the smooth-muscle action of a large number of biogenic amines and polypeptides, the accelerated migration of leucocytes induced by endotoxin, and the Schultz-Dale phenomenon. In vivo, the compound shows anti-inflammatory and anti-allergic effects and improves the survival rate of infected mice treated with suboptimal doses of a sulphonamide.     

Intranukleäre Einschlusskörper in Neuronen alternder Ratten

Summary Intranuclear rodlet shaped structures similar to those recently observed in human multiple sclerosis biopsy material were found in cortical neurons of aging rats. The morphology of these structures is described and their possible significance discussed.     

Über die Wirkung von Mischungen eines antigenhaltigen Plasmas mit einem antikörperhaltigen Serum auf die Entwicklung des Fremdkörpergranuloms

Summary It has been shown that local application of a mixture of precipitating antiserum with homologous plasma or serum promotes markedly the growth of granuloma tissue in the rat.     

Hemmung der durch Proteuslipopolysaccharide gesteigerten Leukozytenemigration in vitro durch antiinflammatorische Corticosteroide

Summary The migration of leucocytes from the buffy coat of chicken blood is slightly but irregulatly inhibited by cortison. If migration of leucocytes is increased by proteus lipopolysaccharide, cortison in concentrations of 10^–4–10^–6, and other anti-inflammatory steroids, produce a pronounced and constant inhibition of leucocytic migration.