广义特征值摄动问题的逐步逼近法

以子空间缩聚及正交分解为基础，根据实矩阵的奇异值分解定理，对广义特征值摄动问题，提出了一种能同时有效地处理孤立特征值、相重特征值及相近特征值三种不同情况的逐步逼近法．计算实例表明，该方法合理可靠、精度高     

基于小波变换的低频数字水印嵌入算法

提出了一种基于小波变换低频系数的数字水印嵌入和检测算法．二值水印首先经过Arnold变换后再嵌入在原始图像的低频部分，仍能保持良好的视觉效果，进一步证明了低频部分不是水印的禁区．实验结果表明该算法有较好抗JPEG压缩、低通滤波等攻击的能力．     

浅谈电子信息资源的合法利用

网络时代，电子信息资源已成为人们进行科学研究、商业活动和共享信息的重要手段，与此同时，网上侵权行为也时有发生。指出了电子信息资源的侵权形式，探讨了在版权法允许的范围内合法利用电子信息资源的有关问题。     

浅议中小企业的财务管理

财务管理在企业经营管理决策中起着重要的作用，分析了目前中小企业财务管理中存在的问题，从投资模式、管理控制和人员素质等3方面提出了解决这些问题的对策。     

RF channel performance assessment for a multiple carrier millimeter-wave communication system

Channel capacity, system versatility and ease of maintenance are factors of prime concern in future generations of wireless communication systems. As a result, millimeter-wave can offer considerable advantages in providing broadband interface. Nonlinearity and noise effects, including parametric fluctuations, are two significant causes for signal degradation in broadband communication systems. Two methods to assess the performance of an RF channel in a multi-carrier system are described. By measuring the forward transfer function from transmitter IF to receiver IF as the frequency is swept across the channel bandwidth, characteristics such as gain flatness, channel dispersion, and saturation effects are revealed. To evaluate the ability of the communication link in preserving the synchronization between two carriers, their heterodyned spectrum at the receiver IF output is studied. Both measurement methods employ standard equipment and have been found to be effective when applied to a multi-carrier millimeter-wave system with over 1 GHz instantaneous bandwidth.     

CeO_2纳米线阵列的制备

以阳极氧化铝膜(AAO)为模板通过溶胶-凝胶法合成了CeO2 纳米线阵列,并通过扫描电子显微镜(SEM)、透射电子显微镜(TEM)以及X射线光电子能谱(XPS)等对CeO2 纳米线进行了表征.     

音乐的结构及其数字人类学根据

音乐作为一种纯粹的文化制度,有其固有的结构和强加的结构。音乐结构原理的应用有力地说明,音乐有其明确规定的数字人类学根据。     

STUDY ON THE ELEMENTAL CHLORINE FREE BLEACHING OF BAMBOO KRAFT PULP

1INTRODUCTIONChina is a country using the most variety of non-wood fiber raw material and is the largest country producing non-wood fiber pulp and paper in the world[1]. Bamboo is one kind of the main non-wood species for papermaking in China. Although the structure of raw materials for papermaking has being adjusted through increasing the proportion of wood pulp and by effectively utilizing waste paper source, non-wood species will still remain an important fiber resource[1,2].At present…     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.