转炉炼钢厂钢包转运的物理模型

在对炼钢厂钢包转运过程进行解析中,给出了钢包运行时间因素的数学描述,提出了钢包转运过程的“柔性时间”概念和钢包使用个数的计算方法,同时,对钢包运行的优化进行了分析,建立了钢包转运的物理模型。     

Genomic instability in Gadd45a-deficient mice.

Gadd45a-null mice generated by gene targeting exhibited several of the phenotypes characteristic of p53-deficient mice, including genomic instability, increased radiation carcinogenesis and a low frequency of exencephaly. Genomic instability was exemplified by aneuploidy, chromosome aberrations, gene amplification and centrosome amplification, and was accompanied by abnormalities in mitosis, cytokinesis and growth control. Unequal segregation of chromosomes due to multiple spindle poles during mitosis occurred in several Gadd45a -/- cell lineages and may contribute to the aneuploidy. Our results indicate that Gadd45a is one component of the p53 pathway that contributes to the maintenance of genomic stability.     

Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation

Mesolimbic dopamine-releasing neurons appear to be important in the brain reward system. One behavioural paradigm that supports this hypothesis is intracranial self-stimulation (ICS), during which animals repeatedly press a lever to stimulate their own dopamine-releasing neurons electrically. Here we study dopamine release from dopamine terminals in the nucleus accumbens core and shell in the brain by using rapid-responding voltammetric microsensors during electrical stimulation of dopamine cell bodies in the ventral tegmental area/substantia nigra brain regions. In rats in which stimulating electrode placement failed to elicit dopamine release in the nucleus accumbens, ICS behaviour was not learned. In contrast, ICS was acquired when stimulus trains evoked extracellular dopamine in either the core or the shell of the nucleus accumbens. In animals that could learn ICS, experimenter-delivered stimulation always elicited dopamine release. In contrast, extracellular dopamine was rarely observed during ICS itself. Thus, although activation of mesolimbic dopamine-releasing neurons seems to be a necessary condition for ICS, evoked dopamine release is actually diminished during ICS. Dopamine may therefore be a neural substrate for novelty or reward expectation rather than reward itself.     

星形胶质细胞低温去分化条件

体外纯化培养的成熟星形胶质细胞经冷冻复苏方法处理后,诱导转化为放射状胶质细胞的类似细胞(RGLCs细胞).星形胶质细胞的诱导转化率与其冷冻过程的温度、时间有关.冷冻保护液中的DMSO对星形胶质细胞的诱导转化过程无关.这些结果显示冷冻复苏方法诱导星形胶质细胞的转化是由物理刺激诱导的.     

Effect of actinomycin D on Trypanosoma cruzi

Viable metacyclic forms of T. cruzi, Y strain, treated with an adequate dose of actinomycin D (50 micrograms Act-D/ml/10(7) parasites/ml for 72 h at 28 degrees C) showed the following properties: 1) they lost their ability to replicate in culture medium, in blood and in tissues of normal mice and were no longer able to incorporate tritiated thymidine; 2) they could not penetrate into Vero cells and could not replicate inside normal macrophages; 3) they retained their immunogenicity and the ability to protect mice against a virulent infection; 4) they did not induce histological lesions as described in chronic experimental Chagas' disease.     

硬质合金刀片槽型实物模型参数化设计

提出了刀片槽型参数化设计思想，进而进一步提出了槽型参数化设计的尺寸驱动的参数化设计算法及其在ＡｕｔｏＣＡＤ进行二次开发的实现方法。     

I-内射模及其性质

假设A是交换的Noether环,I是A任意给定的理想,并且满足ht(I)＞0。本文将内射模的概念在一定意义上进行推广,给出I-内射模的概念及其性质,并定义了模的I-内射维数以及环上的整体I-维数。     

A Cooperative Schema between Web Sever and Search Engine for Improving Freshness of Web Repository

0 IntroductionTIon tceorpneet w ,itthhefr cerqauwelnetr sch oafn sgeeasr cohf tehneg iinnfeo rnemeadti toon uopnd tahteethe web pages visited. Different pages have different changefrequencies[1].Sothe crawlers must firstly esti mate which pa-ges need to b…