350例男性不育症原因临床分析

1979～1983年我科诊治350例男性不育症,基本原因归纳为三大类:精子质量差199例,占56.86％;并发前列腺炎、精索静脉曲张、睾丸附睾炎者共154例,无精子症65例,占18.57;性功能障碍86例,占24.57％。精子质量差患者中,并发附属性腺炎症十分明显,对两者关系作了阐述;对无精子症患者经双侧输精管通水或精道造影术及双侧皋丸病理活检,显示了睾丸组织有明显损害;性功能障碍患者经病史调查分析说明绝大多数为功能性的。     

Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium

The autosomal dominant, giant-platelet disorders, May-Hegglin anomaly (MHA; MIM 155100), Fechtner syndrome (FTNS; MIM 153640) and Sebastian syndrome (SBS), share the triad of thrombocytopenia, large platelets and characteristic leukocyte inclusions ('D?hle-like' bodies). MHA and SBS can be differentiated by subtle ultrastructural leukocyte inclusion features, whereas FTNS is distinguished by the additional Alport-like clinical features of sensorineural deafness, cataracts and nephritis. The similarities between these platelet disorders and our recent refinement of the MHA (ref. 6) and FTNS (ref. 7) disease loci to an overlapping region of 480 kb on chromosome 22 suggested that all three disorders are allelic. Among the identified candidate genes is the gene encoding nonmuscle myosin heavy chain 9 (MYH9; refs 8-10), which is expressed in platelets and upregulated during granulocyte differentiation. We identified six MYH9 mutations (one nonsense and five missense) in seven unrelated probands from MHA, SBS and FTNS families. On the basis of molecular modelling, the two mutations affecting the myosin head were predicted to impose electrostatic and conformational changes, whereas the truncating mutation deleted the unique carboxy-terminal tailpiece. The remaining missense mutations, all affecting highly conserved coiled-coil domain positions, imparted destabilizing electrostatic and polar changes. Thus, our results suggest that mutations in MYH9 result in three megakaryocyte/platelet/leukocyte syndromes and are important in the pathogenesis of sensorineural deafness, cataracts and nephritis.     

BALANCING TORQUE OF SINGLES COTTON ROTOR YARNS

This paper reports a recent development of a yarn modification process to produce torque balanced singles spun yarns. Taking advantages of the core-sheath structure of unconventional spun yarns, we have developed a yarn modification process and applied it to singles yarns spun by rotor spinning. Torque free singles yarns have been produced from 100% cotton fibers. The spirality of resultant single jersey knit fabrics has been greatly reduced or, in some cases, completely eliminated. Properties and performance characteristics of both parent and modified yarns as well as their resultant fabrics have been evaluated including the yarn tensile properties, surface properties, handle, air permeability, burst strength, and pilling resistance of the fabrics.     

琅琊山森林群落演替预测

本研究把中心点——四分面和我们提出的“树冠权重更新面积”(TCWRA)结合起来,运用于野外植被资料的取样。在此基础上,用Markov过程描述了琅琊山森林群落线性和非线性演替,预测了平衡时群落空间各层次林木的组成状态。研究结果表明,琅琊山森林群落在没有外界大的干扰下,麻栎、化香种群将从该群落中消退,发展成以青檀、五角枫、榉树为优势种群的顶极群落。     

A novel MHC class II epitope expressed in thymic medulla but not cortex

The repertoire of receptors expressed by peripheral T cells is the result of two selective events that occur during intrathymic development. Positive selection expands cells able to recognize foreign peptides presented by self MHC molecules, and negative selection eliminates cells reactive to self MHC molecules and associated self peptides. Chimaera studies suggest that, at least in the case of T cells recognizing MHC class II, interaction with thymic cortical epithelial cells is responsible for the former, whereas thymic medullary cells, of bone marrow origin, mediate the latter. This view of thymic development is supported by recent morphometric analyses, showing that autoreactive cells are found in thymic cortex but not medulla. Although numerous studies have shown that MHC class II molecules are expressed in both sites, none provides any explanation for the differential selection of T cells that is observed. Here, we describe a novel MHC class II epitope which is found on cells in thymic medulla but not cortex. The antibody to this epitope reacts with about 10% of class II molecules on B cells and may be recognizing a self peptide-MHC complex. These results provide the first evidence for differential expression of class II epitopes in different tissues and are compatible with the hypothesis that different ligands, rather than different affinity thresholds for the same ligand, are involved in positive and negative selection of the T-cell repertoire.     

Abnormal differentiation of thymocytes in mice treated with cyclosporin A

Cyclosporin A (CsA) acts as a powerful immunosuppressive agent, and also, when given in repeated doses, can cause T-cell-dependent graft-versus-host disease and organ-specific autoimmune disease in rodents. This suggests that CsA interferes with the processes governing self-tolerance, either by nullifying the activity of T suppressor cells or by preventing the deletion of autoreactive T cells during ontogeny in the thymus. We report here that irradiated mice given repeated injections of CsA show striking dysfunction of the thymus. There are two different effects, the first of which is that CsA seems to block the differentiation of immature CD4+CD8+ thymocytes into mature CD4+CD8- and CD4-CD8+ cells expressing a high density of T-cell receptors and CD3 molecules. Second, CsA-treated mice show incomplete deletion of T cells expressing T-cell receptor molecules reactive to self H-2 I-E molecules.     

The Behavior of the Rotor Spun Yarn(OE yarn)with Involving Twist

The rotor spun yarn(OE yarn),twist of which is calledlayering twist,was added a few involving twist,and itsstructure and properties were measured.The experimen-tal results have shown that the morphological structure ofthe rotor spun yarn with modified twist was changed andits tensile properties and abrasion resistance were im-proved.     

Forecasting Latent Volatility through a Markov Chain Approximation Filter

We propose a new methodology for filtering and forecasting the latent variance in a two‐factor diffusion process with jumps from a continuous‐time perspective. For this purpose we use a continuous‐time Markov chain approximation with a finite state space. Essentially, we extend Markov chain filters to processes of higher dimensions. We assess forecastability of the models under consideration by measuring forecast error of model expected realized variance, trading in variance swap contracts, producing value‐at‐risk estimates as well as examining sign forecastability. We provide empirical evidence using two sources, the S&P 500 index values and its corresponding cumulative risk‐neutral expected variance (namely the VIX index). Joint estimation reveals the market prices of equity and variance risk implicit by the two probability measures. A further simulation study shows that the proposed methodology can filter the variance of virtually any type of diffusion process (coupled with a jump process) with a non‐analytical density function. Copyright © 2015 John Wiley & Sons, Ltd.     

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

We characterized the mutational landscape of melanoma, the form of skin cancer with the highest mortality rate, by sequencing the exomes of 147 melanomas. Sun-exposed melanomas had markedly more ultraviolet (UV)-like C>T somatic mutations compared to sun-shielded acral, mucosal and uveal melanomas. Among the newly identified cancer genes was PPP6C, encoding a serine/threonine phosphatase, which harbored mutations that clustered in the active site in 12% of sun-exposed melanomas, exclusively in tumors with mutations in BRAF or NRAS. Notably, we identified a recurrent UV-signature, an activating mutation in RAC1 in 9.2% of sun-exposed melanomas. This activating mutation, the third most frequent in our cohort of sun-exposed melanoma after those of BRAF and NRAS, changes Pro29 to serine (RAC1(P29S)) in the highly conserved switch I domain. Crystal structures, and biochemical and functional studies of RAC1(P29S) showed that the alteration releases the conformational restraint conferred by the conserved proline, causes an increased binding of the protein to downstream effectors, and promotes melanocyte proliferation and migration. These findings raise the possibility that pharmacological inhibition of downstream effectors of RAC1 signaling could be of therapeutic benefit.     

Forecasting price delay and future stock returns: The role of corporate social responsibility

This paper investigates the role of corporate social responsibility (CSR) performance in forecasting companys' stock prices and future returns. The forecasting analysis identifies a negative association between CSR performance and proxies of price delay. The negative CSR–delay association is weak for state‐owned enterprises (SOEs) because of their politically oriented motivation of CSR activities, but significantly strong for non‐SOEs. Furthermore, we find that forecasting delayed firms is expected to have higher future returns. In particular, the returns premium is most attributable to the CSR component of delay, compared with the non‐CSR component. Taken together, these results suggest that CSR performance plays a positive role in enhancing stock price efficiency, and a potential explanation is that CSR performance can be considered as additional information for equity predictions.