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881.
882.
Chemical investigation of hassium (element 108) 总被引:5,自引:0,他引:5
Düllmann ChE Brüchle W Dressler R Eberhardt K Eichler B Eichler R Gäggeler HW Ginter TN Glaus F Gregorich KE Hoffman DC Jäger E Jost DT Kirbach UW Lee DM Nitsche H Patin JB Pershina V Piguet D Qin Z Schädel M Schausten B Schimpf E Schött HJ Soverna S Sudowe R Thörle P Timokhin SN Trautmann N Türler A Vahle A Wirth G Yakushev AB Zielinski PM 《Nature》2002,418(6900):859-862
The periodic table provides a classification of the chemical properties of the elements. But for the heaviest elements, the transactinides, this role of the periodic table reaches its limits because increasingly strong relativistic effects on the valence electron shells can induce deviations from known trends in chemical properties. In the case of the first two transactinides, elements 104 and 105, relativistic effects do indeed influence their chemical properties, whereas elements 106 and 107 both behave as expected from their position within the periodic table. Here we report the chemical separation and characterization of only seven detected atoms of element 108 (hassium, Hs), which were generated as isotopes (269)Hs (refs 8, 9) and (270)Hs (ref. 10) in the fusion reaction between (26)Mg and (248)Cm. The hassium atoms are immediately oxidized to a highly volatile oxide, presumably HsO(4), for which we determine an enthalpy of adsorption on our detector surface that is comparable to the adsorption enthalpy determined under identical conditions for the osmium oxide OsO(4). These results provide evidence that the chemical properties of hassium and its lighter homologue osmium are similar, thus confirming that hassium exhibits properties as expected from its position in group 8 of the periodic table. 相似文献
883.
Increasing dominance of large lianas in Amazonian forests 总被引:1,自引:0,他引:1
Phillips OL Vásquez Martínez R Arroyo L Baker TR Killeen T Lewis SL Malhi Y Monteagudo Mendoza A Neill D Núñez Vargas P Alexiades M Cerón C Di Fiore A Erwin T Jardim A Palacios W Saldias M Vinceti B 《Nature》2002,418(6899):770-774
Ecological orthodoxy suggests that old-growth forests should be close to dynamic equilibrium, but this view has been challenged by recent findings that neotropical forests are accumulating carbon and biomass, possibly in response to the increasing atmospheric concentrations of carbon dioxide. However, it is unclear whether the recent increase in tree biomass has been accompanied by a shift in community composition. Such changes could reduce or enhance the carbon storage potential of old-growth forests in the long term. Here we show that non-fragmented Amazon forests are experiencing a concerted increase in the density, basal area and mean size of woody climbing plants (lianas). Over the last two decades of the twentieth century the dominance of large lianas relative to trees has increased by 1.7-4.6% a year. Lianas enhance tree mortality and suppress tree growth, so their rapid increase implies that the tropical terrestrial carbon sink may shut down sooner than current models suggest. Predictions of future tropical carbon fluxes will need to account for the changing composition and dynamics of supposedly undisturbed forests. 相似文献
884.
The harlequin mouse mutation downregulates apoptosis-inducing factor 总被引:35,自引:0,他引:35
Klein JA Longo-Guess CM Rossmann MP Seburn KL Hurd RE Frankel WN Bronson RT Ackerman SL 《Nature》2002,419(6905):367-374
Harlequin (Hq) mutant mice have progressive degeneration of terminally differentiated cerebellar and retinal neurons. We have identified the Hq mutation as a proviral insertion in the apoptosis-inducing factor (Aif) gene, causing about an 80% reduction in AIF expression. Mutant cerebellar granule cells are susceptible to exogenous and endogenous peroxide-mediated apoptosis, but can be rescued by AIF expression. Overexpression of AIF in wild-type granule cells further decreases peroxide-mediated cell death, suggesting that AIF serves as a free radical scavenger. In agreement, dying neurons in aged Hq mutant mice show oxidative stress. In addition, neurons damaged by oxidative stress in both the cerebellum and retina of Hq mutant mice re-enter the cell cycle before undergoing apoptosis. Our results provide a genetic model of oxidative stress-mediated neurodegeneration and demonstrate a direct connection between cell cycle re-entry and oxidative stress in the ageing central nervous system. 相似文献
885.
Active genes are tri-methylated at K4 of histone H3 总被引:92,自引:0,他引:92
Santos-Rosa H Schneider R Bannister AJ Sherriff J Bernstein BE Emre NC Schreiber SL Mellor J Kouzarides T 《Nature》2002,419(6905):407-411
Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not in silent heterochromatic sites. Here we show that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes. Using antibodies that discriminate between the di- and tri-methylated state of K4 we show that di-methylation occurs at both inactive and active euchromatic genes, whereas tri-methylation is present exclusively at active genes. It is therefore the presence of a tri-methylated K4 that defines an active state of gene expression. These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications. 相似文献
886.
887.
Magnetic fields affect the motion of electrons and the orientation of spins in solids, but are thought to have little impact on crystal structure, particularly in compounds with low magnetic susceptibility, such as antiferromagnets. Here we describe an unexpected magnetic effect on crystal shape, in which the direction of the crystal's axes are swapped and the shape changes when a magnetic field is applied; this in turn induces curious memory effects in resistivity and magnetic susceptibility. Ironically, this phenomenon occurs in one of the most well-studied two-dimensional antiferromagnets, La(2-x)Sr(x)CuO(4). 相似文献
888.
Coulomb blockade and the Kondo effect in single-atom transistors 总被引:7,自引:0,他引:7
Park J Pasupathy AN Goldsmith JI Chang C Yaish Y Petta JR Rinkoski M Sethna JP Abruña HD McEuen PL Ralph DC 《Nature》2002,417(6890):722-725
Using molecules as electronic components is a powerful new direction in the science and technology of nanometre-scale systems. Experiments to date have examined a multitude of molecules conducting in parallel, or, in some cases, transport through single molecules. The latter includes molecules probed in a two-terminal geometry using mechanically controlled break junctions or scanning probes as well as three-terminal single-molecule transistors made from carbon nanotubes, C(60) molecules, and conjugated molecules diluted in a less-conducting molecular layer. The ultimate limit would be a device where electrons hop on to, and off from, a single atom between two contacts. Here we describe transistors incorporating a transition-metal complex designed so that electron transport occurs through well-defined charge states of a single atom. We examine two related molecules containing a Co ion bonded to polypyridyl ligands, attached to insulating tethers of different lengths. Changing the length of the insulating tether alters the coupling of the ion to the electrodes, enabling the fabrication of devices that exhibit either single-electron phenomena, such as Coulomb blockade, or the Kondo effect. 相似文献
889.
Jinsong Li Dayuan Chen Zhiming Han Ziyu Zhu Duancheng Wen Qingyuan Sun Zhonghua Liu Minkang Wang Li Lian Jun Du Pengyan Wang Hemin Zhang 《科学通报(英文版)》2002,47(6):467-469
Interspecies somatic nuclear transfer (NT) may provide a new approach for preservation of the endangered rare species. Previous
interspecies cloning studies have shown that a nucleus from a quiescent somatic cell supports early development of reconstructed
embryos in the ooplasm from another species. In this study, we transferred nonquiescent somatic cells from a giant panda into
the perivitelline space of the enucleated rabbit oocytes. After electrofusion (at the rate of 71.6%) and electrical activation,
4.2% of the panda-rabbit reconstructed embryos developed to blastocyst in vitro. For improving the development rate of reconstructed embryos, we used serial NT in this study, i.e. blastomeres from reconstructed
morulae were transferred into the perivitelline space of the enucleated rabbit oocytes. The fusion rates in the groups of
serial I, serial II and serial III were 79.5%, 84.1% and 78.0%, respectively, having no difference with that of somatic group.
And the blastocyst rates in serial NT groups were 19.4%, 13.5% and 10.3%, respectively, which are significantly higher than
that in somatic NT group. These results indicate that the nuclei from nonquiescent somatic cells can support early development
of reconstructed embryos and serial NT can improve the development rate of interspecies reconstructed embryos.
These authors contributed equally to this work. 相似文献
890.
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer 总被引:26,自引:0,他引:26
Tomlinson IP Alam NA Rowan AJ Barclay E Jaeger EE Kelsell D Leigh I Gorman P Lamlum H Rahman S Roylance RR Olpin S Bevan S Barker K Hearle N Houlston RS Kiuru M Lehtonen R Karhu A Vilkki S Laiho P Eklund C Vierimaa O Aittomäki K Hietala M Sistonen P Paetau A Salovaara R Herva R Launonen V Aaltonen LA;Multiple Leiomyoma Consortium 《Nature genetics》2002,30(4):406-410