On the occurrence of homovanillic acid and 3-methoxy-4-hydroxymandelic acid in human cerebrospinal fluid

Zusammenfassung Es wird papierchromatographisch gezeigt, dass Cerebrospinalflüssigkeit gesunder Menschen sowohl Homovanillinsäure als auch 3-Methoxy-4-hydroxymandelsäure enthält. Die Konzentration der ersteren ist etwa 75 ng/ml und die der letzteren etwa 25 ng/ml.

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Acknowledgment. This work has been supported by grants from Leo Ltd., Hälsingborg, and from the Medical Faculty, University of Göteborg (Sweden). For technical assistance we are indebted to Mrs.I. Olofson.     

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

From the complete nucleotide sequence of the genome of the avian sarcoma virus Y73, we have predicted amino acid sequence of p90 gag-yes, the product of the transforming gene. Contrary to previous evidence from molecular hybridization studies p90 gag-yes was found to have much homology with the transforming gene product p60 src of Rous sarcoma virus, suggesting that the cellular counterparts of the two (c-yes and c-src) originated from a common prototype sequence.     

Does nitrogen mustard mimic the X-ray effects in any case?

Résumé Les effets de l'ypérite nitrée sur le cerveau et yeux de l'embryon du rat blanc ont été analysés. Seulement les embryons présentant un aspect normal ont été coupés et colorés. De larges centres de nécrose ont été trouvés sur les coupes tandis que les «rosettes» n'ont pas pu être décelées.Bien que connue comme radiomimétique, l'yperite nitrée ne mime pas les rayons X en ce qui concerne la formation des «rosettes» dans le cerveau.     

Adenosine-induced slow ionic currents in the Xenopus oocyte

Adenosine and its 5'-phosphorylated congeners evoke specific membrane-mediated responses in excitable tissues. Available data suggest that inhibition of the target cell occurs due to hyperpolarization, and in some preparations a compound effect of ATP (excitation and inhibition) has been found. However, the ionic mechanism of the purinergic-mediated response has not been studied by standard intracellular voltage-clamping techniques. Recently, we have discovered purinergic receptors in the Xenopus oocyte, a well defined giant cell amenable to rigorous electrophysiological and biochemical studies. We report here that in these cells, adenosine-induced slow membrane responses consisted of an early depolarizing (D) transient current carried by Cl ions, followed by a steady hyperpolarizing (H) current involving K+ ions. The relative potency sequence for the D current was ATP congruent to ADP greater than AMP congruent to adenosine; this order was reversed for the H current.