Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

The Wellcome Trust Case Control Consortium (WTCCC) primary genome-wide association (GWA) scan on seven diseases, including the multifactorial autoimmune disease type 1 diabetes (T1D), shows associations at P < 5 x 10(-7) between T1D and six chromosome regions: 12q24, 12q13, 16p13, 18p11, 12p13 and 4q27. Here, we attempted to validate these and six other top findings in 4,000 individuals with T1D, 5,000 controls and 2,997 family trios independent of the WTCCC study. We confirmed unequivocally the associations of 12q24, 12q13, 16p13 and 18p11 (P(follow-up) 相似文献   

大型结构振动分析的快速矩阵指数法

提出了快速矩阵指数法，并将它应用于大型结构的振动分析．以高层建筑为对象，分别计算了10层和30层楼房在外激励作用下的位移响应，在快速矩阵指数法中，每一时间步长是其前一时间步长的2倍．而且能够提供较多的系统信息．实例计算表明，该方法收敛速度快、计算效率高、具有良好的精确度。     

Effect of Splice Marking on Fabric Roll Planning

Minimising the fabric loss during spreading can reduce the total production costs of garment manufacturing. Although marker planning is a major determinant of material utilisation, considerable savings on materials also will be made from the area of spreading loss. In the spreading process, it is general to have variance on the fabric yardage between each fabric roll, and the number of splice markings on each cutting lay is also varied. This paper aim to study how the fabric roll planning and the number of splice marks of a cutting lay will affect the material usage in the spreading process. By using a genetic algorithm approach, the amount of fabric to be saved by optimising the fabric roll sequence was derived by comparing the best arrangement and the worst arrangement of the fabric roll sequences of a cutting lay. The result of the study showed that both fabric roll planning and the number of splice marking have effect on the fabric loss. The findings could help the apparel manufacturer to reduce the     

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

The spliceosome is a dynamic macromolecular machine that assembles on pre-messenger RNA substrates and catalyses the excision of non-coding intervening sequences (introns). Four of the five major components of the spliceosome, U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), contain seven Sm proteins (SmB/B', SmD1, SmD2, SmD3, SmE, SmF and SmG) in common. Following export of the U1, U2, U4 and U5 snRNAs to the cytoplasm, the seven Sm proteins, chaperoned by the survival of motor neurons (SMN) complex, assemble around a single-stranded, U-rich sequence called the Sm site in each small nuclear RNA (snRNA), to form the core domain of the respective snRNP particle. Core domain formation is a prerequisite for re-import into the nucleus, where these snRNPs mature via addition of their particle-specific proteins. Here we present a crystal structure of the U4 snRNP core domain at 3.6?? resolution, detailing how the Sm site heptad (AUUUUUG) binds inside the central hole of the heptameric ring of Sm proteins, interacting one-to-one with SmE-SmG-SmD3-SmB-SmD1-SmD2-SmF. An irregular backbone conformation of the Sm site sequence combined with the asymmetric structure of the heteromeric protein ring allows each base to interact in a distinct manner with four key residues at equivalent positions in the L3 and L5 loops of the Sm fold. A comparison of this structure with the U1 snRNP at 5.5?? resolution reveals snRNA-dependent structural changes outside the Sm fold, which may facilitate the binding of particle-specific proteins that are crucial to biogenesis of spliceosomal snRNPs.     

以新一代高效基因芯片辅助培育抗病、耐冷优良水稻品种

稻瘟病是最具毁灭性的水稻病害,大多数抗病品种推广应用1～3年后即丧失其稻瘟病抗性,提高水稻品种稻瘟病抗性、延长抗性寿命已成为水稻改良中急需解决的问题。另外,发生在2～4月间的低温常导致我国南方早稻烂秧率30％～40％,重者可达60％～70％,这是我国南方早造常规籼稻和杂交籼稻减产的主要因素之一。     

FRP加固混凝土梁中弯曲和弯剪裂缝引起的FRP剥离破坏试验

采用同样尺寸的钢梁和混凝土梁,通过中间绞结和底面粘贴FRP布而形成的组合梁,对其进行抗弯试验来研究钢筋混凝土梁弯曲或弯剪裂缝所导致的FRP剥离破坏.试验共设计了7组21根组合梁,通过2个对称的集中荷载进行抗弯试验,重点研究了组合梁破坏过程和形态、FRP布在加载过程中应变分布的规律、不同的裂缝开展程度对组合梁初裂荷载和极限承载能力的影响以及混凝土强度对FRP与混凝土粘结强度的影响.试验结果表明:组合梁的初裂荷载与FRP的长度没有关系,主要取决于裂缝的竖向位移;裂缝的竖向位移和FRP的长度对梁的极限荷载具有较大的影响,特别是在FRP锚固长度较小的情况下.针对梁中弯曲及弯剪裂缝引起的FRP剥离破坏进行了深入的试验研究,为工程结构加固提供了一定的参考依据.     

Intact teratogenic immunoglobulins may reach the rat embryo

It is known that heterologous antiserum against rat kidney homogenate may induce congenital malformations when injected into pregnant rats during the period of organogenesis. Teratogenic rabbit antibodies against a purified rat renal tubular glycoprotein were isolated, labelled with 125I and injected into pregnant rats on the 10th day of gestation. Extracts of visceral yolk-sacs (VYS) and embryos were obtained 16 h later and chromatographed separately on a Sephacryl S-300 gel filtration column. The resultant chromatograms showed several radioactive peaks, one of which coincided with the eluate of intact rabbit immunoglobulins G (IgG). We interpret the result as an indication that some undigested intact teratogenic IgG were present in VYS and the embryo.