全文获取类型
收费全文 | 1463篇 |
免费 | 46篇 |
国内免费 | 70篇 |
专业分类
系统科学 | 55篇 |
丛书文集 | 51篇 |
教育与普及 | 21篇 |
理论与方法论 | 13篇 |
现状及发展 | 248篇 |
研究方法 | 46篇 |
综合类 | 1141篇 |
自然研究 | 4篇 |
出版年
2023年 | 11篇 |
2022年 | 29篇 |
2021年 | 44篇 |
2020年 | 35篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 24篇 |
2016年 | 31篇 |
2015年 | 52篇 |
2014年 | 62篇 |
2013年 | 76篇 |
2012年 | 91篇 |
2011年 | 93篇 |
2010年 | 82篇 |
2009年 | 72篇 |
2008年 | 87篇 |
2007年 | 95篇 |
2006年 | 64篇 |
2005年 | 37篇 |
2004年 | 36篇 |
2003年 | 39篇 |
2002年 | 39篇 |
2001年 | 39篇 |
2000年 | 38篇 |
1999年 | 24篇 |
1998年 | 16篇 |
1997年 | 7篇 |
1996年 | 8篇 |
1995年 | 8篇 |
1994年 | 8篇 |
1993年 | 12篇 |
1992年 | 8篇 |
1990年 | 14篇 |
1989年 | 9篇 |
1987年 | 8篇 |
1985年 | 7篇 |
1980年 | 7篇 |
1979年 | 14篇 |
1978年 | 6篇 |
1977年 | 13篇 |
1974年 | 16篇 |
1973年 | 15篇 |
1972年 | 16篇 |
1971年 | 25篇 |
1970年 | 13篇 |
1969年 | 18篇 |
1968年 | 22篇 |
1967年 | 14篇 |
1966年 | 12篇 |
1965年 | 10篇 |
排序方式: 共有1579条查询结果,搜索用时 0 毫秒
81.
Strong evidence for a genetic basis of variation in physical performance has accumulated. Considering one of the basic tenets of evolutionary physiology--that physical performance and darwinian fitness are tightly linked--one may expect phenotypes with exceptional physiological capacities to be promoted by natural selection. Why then does physical performance remain considerably variable in human and other animal populations? Our analysis of locomotor performance in the common lizard (Lacerta vivipara) demonstrates that initial endurance (running time to exhaustion measured at birth) is indeed highly heritable, but natural selection in favour of this trait can be unexpectedly weak. A manipulation of dietary conditions unravels a proximate mechanism explaining this pattern. Fully fed individuals experience a marked reversal of performance within only one month after birth: juveniles with low endurance catch up, whereas individuals with high endurance lose their advantage. In contrast, dietary restriction allows highly endurant neonates to retain their locomotor superiority as they age. Thus, the expression of a genetic predisposition to high physical performance strongly depends on the environment experienced early in life. 相似文献
82.
83.
Homo neanderthalensis has a unique combination of craniofacial features that are distinct from fossil and extant 'anatomically modern' Homo sapiens (modern humans). Morphological evidence, direct isotopic dates and fossil mitochondrial DNA from three Neanderthals indicate that the Neanderthals were a separate evolutionary lineage for at least 500,000 yr. However, it is unknown when and how Neanderthal craniofacial autapomorphies (unique, derived characters) emerged during ontogeny. Here we use computerized fossil reconstruction and geometric morphometrics to show that characteristic differences in cranial and mandibular shape between Neanderthals and modern humans arose very early during development, possibly prenatally, and were maintained throughout postnatal ontogeny. Postnatal differences in cranial ontogeny between the two taxa are characterized primarily by heterochronic modifications of a common spatial pattern of development. Evidence for early ontogenetic divergence together with evolutionary stasis of taxon-specific patterns of ontogeny is consistent with separation of Neanderthals and modern humans at the species level. 相似文献
84.
Kamath RS Fraser AG Dong Y Poulin G Durbin R Gotta M Kanapin A Le Bot N Moreno S Sohrmann M Welchman DP Zipperlen P Ahringer J 《Nature》2003,421(6920):231-237
85.
Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome 总被引:19,自引:0,他引:19
Ménasché G Pastural E Feldmann J Certain S Ersoy F Dupuis S Wulffraat N Bianchi D Fischer A Le Deist F de Saint Basile G 《Nature genetics》2000,25(2):173-176
Griscelli syndrome (GS, MIM 214450), a rare, autosomal recessive disorder, results in pigmentary dilution of the skin and the hair, the presence of large clumps of pigment in hair shafts and an accumulation of melanosomes in melanocytes. Most patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome (known as haemophagocytic syndrome, HS), leading to death in the absence of bone-marrow transplantation. In contrast, early in life some GS patients show a severe neurological impairment without apparent immune abnormalities. We previously mapped the GS locus to chromosome 15q21 and found a mutation in a gene (MYO5A) encoding a molecular motor in two patients. Further linkage analysis suggested a second gene associated with GS was in the same chromosomal region. Homozygosity mapping in additional families narrowed the candidate region to a 3.1-cM interval between D15S1003 and D15S962. We detected mutations in RAB27A, which lies within this interval, in 16 patients with GS. Unlike MYO5A, the GTP-binding protein RAB27A appears to be involved in the control of the immune system, as all patients with RAB27A mutations, but none with the MYO5A mutation, developed HS. In addition, RAB27A-deficient T cells exhibited reduced cytotoxicity and cytolytic granule exocytosis, whereas MYO5A-defective T cells did not. RAB27A appears to be a key effector of cytotoxic granule exocytosis, a pathway essential for immune homeostasis. 相似文献
86.
Neurulation is a complex process of histogenesis involving the precise temporal and spatial organization of gene expression. Genes influencing neurulation include proneural genes determining primary cell fate, neurogenic genes involved in lateral inhibition pathways and genes controlling the frequency of mitotic events. This is reflected in the aetiology and genetics of human and mouse neural tube defects, which are of both multifactorial and multigenic origin. The X-linked gene Nap1l2, specifically expressed in neurons, encodes a protein that is highly similar to the nucleosome assembly (NAP) and SET proteins. We inactivated Nap1l2 in mice by gene targeting, leading to embryonic lethality from mid-gestation onwards. Surviving mutant chimaeric embryos showed extensive surface ectoderm defects as well as the presence of open neural tubes and exposed brains similar to those observed in human spina bifida and anencephaly. These defects correlated with an overproduction of neuronal precursor cells. Protein expression studies showed that the Nap1l2 protein binds to condensing chromatin during S phase and in apoptotic cells, but remained cytoplasmic during G1 phase. Nap1l2 therefore likely represents a class of tissue-specific factors interacting with chromatin to regulate neuronal cell proliferation. 相似文献
87.
产品开发过程仿真是对产品开发过程进行预测、管理、评价和改进的有效手段.为了对产品开发过程中的人与组织因素进行仿真,提出了一种设计者驱动的产品开发过程仿真原理.重点对设计者智能主体模型进行了研究,采用INTERRAP混合结构建立了设计者智能主体结构模型,用分层有色随机Petri网描述了设计者的个体行为过程与协作行为过程.最后进行了系列仿真实验,初步证明了模型的有效性.基于设计者智能主体模型的过程仿真可在过程预测与评价、人因及组织分析、设计过程改进等方面发挥重要作用. 相似文献
88.
讨论了平行机串联工件同时加工排序问题。目标函数是极小化加权总完工时间,并假设满足每批均含有k个工件,并且每批的加工时间为该批中所有工件的加工时间之和。对平行机的情况,该问题是强NP难的。本文主要针对该问题的两种特殊情况:(1)所有工件的权相等;(2)所有工件的加工时间相等,分别给出了最优算法,分析了算法的时间复杂性,同时用数值例子作了说明。 相似文献
89.
Le Yi WANG G. George YIN 《系统科学与复杂性》2007,20(2):251-261
This paper studies identification of systems in which the system output is quantized, transmitted through a digital communication channel, and observed afterwards. The concept of the CR Ratio is introduced to characterize impact of communication channels on identification. The relationship between the CR Ratio and Shannon channel capacity is discussed. Identification algorithms are further developed when the channel error probability is unknown. 相似文献
90.
为了实现活性污泥资源化,用序批式反应器,分析了典型周期内,聚-β-羟基丁酸酯(PHB)含量与化学需氧量(COD)和总磷(TP)浓度的相关性。用聚合酶链式反应与变性梯度凝胶电泳方法对系统中的活性污泥种群结构进行鉴定,并在好氧曝气条件下,通过投加高浓度碳源,比较了不同PHB含量的活性污泥再次积累PHB的能力。结果表明:COD去除、PHB积累、TP浓度变化符合序批式反应器系统积累PHB的典型模型;转化为PHB的COD量比降解的COD量多出含碳量1.32mmol/L,存在固定CO2的现象;光合细菌红杆菌属是该系统中的优势种群;PHB含量较低、较高的微生物将COD转化为PHB的效率分别为46.54%、29.04%。 相似文献