全文获取类型
收费全文 | 52篇 |
免费 | 0篇 |
专业分类
现状及发展 | 16篇 |
研究方法 | 10篇 |
综合类 | 26篇 |
出版年
2021年 | 1篇 |
2018年 | 1篇 |
2014年 | 1篇 |
2012年 | 3篇 |
2011年 | 3篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2008年 | 3篇 |
2007年 | 2篇 |
2006年 | 8篇 |
2005年 | 2篇 |
2004年 | 2篇 |
2003年 | 1篇 |
2002年 | 1篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1981年 | 2篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1976年 | 3篇 |
1974年 | 1篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1956年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有52条查询结果,搜索用时 15 毫秒
51.
Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR 总被引:1,自引:0,他引:1
Lange A Giller K Hornig S Martin-Eauclaire MF Pongs O Becker S Baldus M 《Nature》2006,440(7086):959-962
The active site of potassium (K+) channels catalyses the transport of K+ ions across the plasma membrane--similar to the catalytic function of the active site of an enzyme--and is inhibited by toxins from scorpion venom. On the basis of the conserved structures of K+ pore regions and scorpion toxins, detailed structures for the K+ channel-scorpion toxin binding interface have been proposed. In these models and in previous solution-state nuclear magnetic resonance (NMR) studies using detergent-solubilized membrane proteins, scorpion toxins were docked to the extracellular entrance of the K+ channel pore assuming rigid, preformed binding sites. Using high-resolution solid-state NMR spectroscopy, here we show that high-affinity binding of the scorpion toxin kaliotoxin to a chimaeric K+ channel (KcsA-Kv1.3) is associated with significant structural rearrangements in both molecules. Our approach involves a combined analysis of chemical shifts and proton-proton distances and demonstrates that solid-state NMR is a sensitive method for analysing the structure of a membrane protein-inhibitor complex. We propose that structural flexibility of the K+ channel and the toxin represents an important determinant for the high specificity of toxin-K+ channel interactions. 相似文献
52.
de Bernardis P Ade PA Bock JJ Bond JR Borrill J Boscaleri A Coble K Crill BP De Gasperis G Farese PC Ferreira PG Ganga K Giacometti M Hivon E Hristov VV Iacoangeli A Jaffe AH Lange AE Martinis L Masi S Mason PV Mauskopf PD Melchiorri A Miglio L Montroy T Netterfield CB 《Nature》2000,404(6781):955-959
The blackbody radiation left over from the Big Bang has been transformed by the expansion of the Universe into the nearly isotropic 2.73 K cosmic microwave background. Tiny inhomogeneities in the early Universe left their imprint on the microwave background in the form of small anisotropies in its temperature. These anisotropies contain information about basic cosmological parameters, particularly the total energy density and curvature of the Universe. Here we report the first images of resolved structure in the microwave background anisotropies over a significant part of the sky. Maps at four frequencies clearly distinguish the microwave background from foreground emission. We compute the angular power spectrum of the microwave background, and find a peak at Legendre multipole Ipeak = (197 +/- 6), with an amplitude delta T200 = (69 +/- 8) microK. This is consistent with that expected for cold dark matter models in a flat (euclidean) Universe, as favoured by standard inflationary models. 相似文献