基于ARMA-EGARCH-M模型的沪深股市波动性分析

文章讨论了ARCH模型族的拟合波动性的优缺点,建立ARMA-EGARCH-M模型,简要说明了此模型的优点;以2000年1月11日-2006年3月15日上证综指和深证成指收盘价为样本,对我国沪深股市收益率分布用ARMA-EGARCH-M模型进行拟合分析,结果表明该模型能更有效地拟合我国沪深股市的波动性;最后解释实证结果和分析了我国股市的行为。     

激光治疗肿瘤的计算研究

根据激光治疗肿瘤的机理建立了激光治疗肿瘤的理论计算模型,并应用有限元计算方法对双光纤照射椭球形肿瘤组织的模型进行了定量计算研究;研究结果表明,对于长轴为2.0 cm、短轴为1.2 cm的实心椭球形肿瘤体,将2个直径为0.4 mm的球状光纤对称放置在主轴上相距0.8~1.0 cm的范围内,可以使光动力学的效果和热疗的效果同时达到最佳值。     

滚动轴承油气润滑性能的试验研究

为了研究不同工况下油气润滑所需的最佳供油量,研制了一台能够对油气润滑滚动轴承温度场进行测量的试验台。通过对比试验研究发现:与传统的连续供油润滑方式相比,油气润滑具有较低的温升;试验研究了油气润滑过程中供油量对润滑效果的影响,发现不同的工况条件对应不同的最佳供油量,以该供油量进行润滑可使滚动轴承的温升最低;通过理论分析,提出了用于描述滚动轴承工况的参数s,并通过大量的试验研究,得到了工况参数s与最佳供油量之间的四次多项式插值曲线,建立了能够对油气润滑最佳供油量进行预测的数学模型,为工程实际应用中最佳供油量的确定提供了重要的理论依据。     

木栅栏砾石笼生态护岸技术及其应用

结合林庄港的生态修复工程建设,系统地研究了木栅栏砾石笼生态护岸的技术要求和生态效果.现场监测结果表明:试验河段内河道水体中CODMn,TN,TP的去除率分别达到20.7%,13.9%,21.1%,同时生态护岸建设前后河段内底栖动物结构、种类和优势物种均出现明显变化,底栖动物的类群发生了由耐污类群为主向中间类群为主的转化,说明木栅栏砾石笼护岸对林庄港河流生态系统的改善和修复有良好的效果.     

基于HMM的多维数据下扶贫对象状态预测

针对扶贫领域中贫困、脱贫和返贫状态预测不准确,影响状态变迁的关键因素难以识别的问题,从扶贫基础数据和多个行业数据中提取8个关键特征和22个观测状态,构建观察状态和隐含状态关联关系,建立扶贫对象状态预测隐马尔可夫模型(hidden markov model,HMM)。以某深度贫困县连续3年的数据为样本,进行参数训练、测试实验和结果验证,结果表明该方法对返贫、贫困和脱贫状态有较强的预测能力,误差率较低,且能准确识别出影响返贫的关键要素。该方法对指导精准扶贫工作具有非常重要的实际意义。     

论洪江市梅园与桔园小区规划设计

以洪江市梅园、桔园小区规划设计为例,在遵循“以人为本”基本原则的前提下,探索了住宅规划设计的新途径和新思路．     

鄂东大别山生物多样性研究

对鄂东大别山区的生物多样性进行了研究.目前已知该区有维管植物195科663属1 461种,占湖北省总种数的24.27%和全国总种数的5.25%,属国家特有、珍稀濒危或重点保护的植物有34种,有苔藓植物30科64属143种.已知该区有陆生脊椎动物26目65科208种,占湖北省总种数的31.04%和全国总种数的8.09%,其中有27种国家重点保护野生动物和61种湖北省级重点保护动物.该区自然植被类型有10个植被型,52个群系.该区不仅动植物区系成分多样性复杂,而且经济类型多样.     

PPAR γ partial agonist, KR-62776, inhibits adipocyte differentiation via activation of ERK

Indenone KR-62776 acts as an agonist of PPARγ without inducing obesity in animal models and cells. X-ray crystallography reveals that the indenone occupies the binding pocket in a different manner than rosiglitazone. 2-Dimensional gel-electrophoresis showed that the expression of 42 proteins was altered more than 2.0-fold between KR-62776- or rosiglitazone-treated adipocyte cells and control cells. Rosiglitazone down-regulated the expression of ERK1/2 and suppressed the phosphorylation of ERK1/2 in these cells. However, the expression of ERK1/2 was up-regulated in KR-62776-treated cells. Phosphorylated ERK1/2, activated by indenone, affects the localization of PPARγ, suggesting a mechanism for indenone-inhibition of adipogenesis in 3T3-L1 preadipocyte cells. The preadipocyte cells are treated with ERK1/2 inhibitor PD98059, a large amount of the cells are converted to adipocyte cells. These results support the conclusion that the localization of PPARγ is one of the key factors explaining the biological responses of the ligands. Received 04 March 2009; received after revision 13 March 2009; accepted 17 March 2009     

Transient and constitutive repression of cytoplasmic translation signaling in cells with mtDNA mutation

Cytoplasmic translation is under sophisticated control but how cells adapt its rate to constitutive loss of mitochondrial oxidative phosphorylation is unknown. Here we show that translation is repressed in cells with the pathogenic A3243G mtDNA mutation or in mtDNA-less ρ⁰ cells by at least two distinct pathways, one transiently targeting elongation factor eEF-2 and the other initiation factor eIF-2α constitutively. Under conditions of exponential cell growth and mammalian target of rapamycin (mTOR) activation, eEF-2 becomes transiently phosphorylated by an AMP-activated protein kinase (AMPK)-dependent pathway, especially high in mutant cells. Independent of AMPK and mTOR, eIF-2α is constitutively phosphorylated in mutant cells, likely a signature of endoplasmic reticulum (ER)-stress response induced by the loss of oxidative phosphorylation. While the AMPK/eEF-2K/eEF-2 pathway appears to function in adaptation to physiological fluctuations in ATP levels in the mutant cells, the ER stress signified by constitutive protein synthesis inhibition through eIF-2α-mediated repression of translation initiation may have pathobiochemical consequences. Received 29 October 2008; received after revision 11 December 2008; accepted 16 December 2008     

基于增量优化传递的正电子发射断层图像重建

将增量优化传递算法用于正电子发射断层图像重建中,得到一种新的最大后验概率图像重建算法,实验结果表明,相对于滤波反投影和最大似然期望值最大化算法,有序子集可分离的抛物面型替代函数算法和发射增量优化传递算法得到的图像归一化均方误差较小,且边界得到一定的保持.在迭代的初期,有序子集可分离的抛物面型替代函数算法收敛较快,误差小;当迭代到一定的次数时,发射增量优化传递算法误差小,且能够有效收敛,对发射扫描断层图像重建产生重要的影响.