Endorcine cells producing regulatory peptides

Summary Recent data on the immunologication of regulatory peptides and related propeptide sequences in endocrine cells and tumours of the gastrointestinal tract pancreas, lung, thyroid, pituitary (ACTH and opioids), adrenals and paraganglia have been revised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory beenrevised and discussed. Gastrin, xenopsin, cholecystokinin (CCK), somatostatin, motilin, secretin, GIP (gastric inhibitory polypeptide), neurotensin, glicentin/glucagon-37 and PYY (peptide tyrosine tyrosine) are the main products of gastrointestinal endocrine cells; glucagon, CRF (corticotropin releasing factor), somatostatin, PP (pancreatic polypeptide) and GRF (growth hormone releasing factor), in addition to insulin, are produced in pancreatic islet cells; bombesin-related peptidesare the main markers of pulmonary endocrine cells; calcitonin and CGRP (calcitonin gene-related peptide) occur in thyroid and extrathyroid C cells; ACTH and endorphins in anterior and intermediate lobe pituitary cells, -MSH and CLIP (corticotropoin-like intermediate lobe peptide) in intermediate lobe cells; met- and leu-enkephalins and related peptides in adrenal medullary and paraganglionic cells as well as in some gut (enterochromaffin) cells; NPY (neuropeptide Y) in adrenalin-type adrenal medullary cells, etc.. Both tissue-appropriate and tissue-inappropriate regulatory peptides are produced by endocrine tumours, with inappropriate peptides mostly produced by malignant tumours.     

Perennial N2 supersaturation in an Antarctic lake

The dry valleys of southern Victoria Land in Antarctica contain several closed basins in which perennially ice-covered lakes are found. One of the most unusual features of these lakes is the occurrence of high O2 concentrations in the water column; values ranging from slightly more than saturation to more than four times saturation have been reported. Recently, we considered a bulk O2 budget for Lake Hoare, Antarctica, which led us to suggest that biological processes alone were not sufficient to explain the observed elevated oxygen levels. Consequently, there must be a non-biological source of O2. We suggested that this source results from the exclusion of O2 during the freezing of aerated meltstream water at the bottom of the ice cover, and predicted that this physical mechanism should also enhance the other atmospheric gases. Here we report the results of a study which, for the first time, documents the supersaturation of N2 in a lake. Dissolved N2 levels of 145% and 163% were determined from samples taken just below the ice cover and at a depth of 12 m, respectively. The relatively importance of biological and abiological sources is reflected in the ratio of N2 concentration to O2 concentration. In Lake Hoare this ratio was 1.20 at ice/water interface and 1.05 at 12 m; considerably different from the ratio in equilibrium with air (approximately 1.8). Based on these results, we have determined that about half of the net O2 production in the lake is the result of biological processes.     

Regulation of cellulose synthesis in Acetobacter xylinum by cyclic diguanylic acid

Cellulose is the most abundant renewable carbon resource on earth and is an indispensable raw material for the wood, paper, and textile industries. A model system to study the mechanism of cellulose biogenesis is the bacterium Acetobacter xylinum which produces pure cellulose as an extracellular product. It was from this organism that in vitro preparations which possessed high levels of cellulose synthase activity were first obtained in both membranous and soluble forms. We recently demonstrated that this activity is subject to a complex multi-component regulatory system, in which the synthase is directly affected by an unusual cyclic nucleotide activator enzymatically formed from GTP, and indirectly by a Ca (2+) -sensitive phosphodiesterase which degrades the activator. The cellulose synthase activator (CSA) has now been identified as bis-(3' 5')-cyclic diguanylic acid (5'G3'p5'G3'p) on the basis of mass spectroscopic data, nuclear magnetic resonance analysis and comparison with chemically synthesized material. We also report here on intermediary steps in the synthesis and degradation of this novel circular dinucleotide, which have been integrated into a model for the regulation of cellulose synthesis.     

正交激励超声切削装置的椭圆轨迹偏转与校正

为研究超声椭圆振动切削（ultrasonic elliptical vibration cutting,UEVC）刀尖轨迹形成及控制,解决刀尖轨迹非正椭圆问题,建立二维正交柔性导波UEVC装置刀尖轨迹的运动学模型;分析90°相位差下非正椭圆轨迹产生原因,建立刀尖轨迹校正模型,并推导出基于正椭圆轨迹下的刀尖轨迹偏转模型。通过实验对刀尖轨迹校正模型进行验证,校正后轨迹偏离坐标轴1.67°,小于校正前偏离角度。实验结果表明,该模型能够有效地校正刀尖轨迹,可在轨迹控制方面为后续研究刀尖轨迹偏转及变刀尖轨迹超声振动加工提供理论基础。     

覆冰地区分裂与扩径导线表面电场特性

输电线路覆冰对电力系统安全运行具有严重威胁,目前已经发展了多种防冰除冰方法,但每种方法都有其局限性,对于一些具有微气象、微地形特征的重覆冰地区尚未有较好的解决方法。文中考虑到扩径导线的特点和分裂导线输电线路的局限性,根据波阻抗和自然功率将分裂导线等效为单导线,并考虑电流的集肤效应,得到了等效的单根扩径导线,进而分析比较覆冰地区的分裂导线及其等效的单根扩径导线的表面电场特性。研究表明：等效前后导线截面面积相同且波阻抗一致时,扩径导线与分裂导线相比,不仅显著降低了子导线根数和输电线路的覆冰荷载,而且在扩径导线的半径等于分裂导线的等效单导线半径时,扩径导线的表面最大电场强度小于分裂导线。因此,在严重覆冰地区,采用分裂导线等效半径的扩径导线具有非常好的表面电场特性,且可显著降低冰风荷载,提高抗冰强度。     

基于改进RPN的孪生小样本电力目标检测

为了解决当前电力系统巡检难度大、效率低、数据不足以支撑大规模训练的问题,提出一种基于孪生网络的小样本检测方法。首先,在Faster RCNN(faster region convolutional neural network)目标识别算法的框架下,搭建支持图片和查询图片共享的孪生网络模型;然后,利用改进的RPN(region proposal network)模块产生更高质量的proposals;最后,在检测头上对支持图片和查询图片的RoI(region of interest)进行关联匹配。结果表明,将算法应用于自主构建的EPD(electric power detection)数据集,在仅利用10张支持图片的情况下,就能实现对电力背景下鸟巢异物和绝缘子相关类别的检测,检测指标mAP达到18.92%。与其他算法相比,应用于电力行业目标检测的孪生网络小样本模型,在极端小样本情况下性能优良,同时具有更加轻量化的优势,可为电力检测新方法研究提供参考。     

紧邻浅埋暗挖地铁隧道地下密集管线及土层变形

针对地铁隧道施工影响下紧邻密集管线保护问题,依托南昌地铁实际工程,采用ABAQUS软件建立土体-密集地下管线-隧道暗挖三维有限元模型,结合现场实测数据与数值模拟结果,分析了隧道CRD (cross diaphragm)工法施工时的地层变形规律、地下管线应力特性与地下管线变形规律,并对管线周边土体有无注浆加固时的管线力学特性进行了对比。研究结果表明：(1)隧道开挖引起的管线变形以沉降为主,管土刚度差异对管线变形和应力影响显著。(2)管土刚度差异越小,管线变形趋势与土体变形趋势越接近;管土刚度差异越大,管线对地层变形的抵抗作用也越强会产生较大应力。(3)隧道左右导洞上方管段是危险区域,需重点保护。(4)密集地下管线主要表现为管线材质、管线几何特性、管线与隧道的空间位置关系不同,保护地下管线的核心在于控制地层沉降,地下管线保护关键阶段是隧道掌子面接近管线,此时应确保超前注浆效果和初期支护快速封闭,并加强对管线变形的监测。     

基于Maxwell和Simplorer的2 kW低速永磁发电机设计

针对低风速、风资源欠佳且用电困难的地区,为改善风力发电机的低速发电性能,提高风能利用率,设计了一种应用于2 kW风力发电机组的低转速永磁发电机,利用磁路法对2 kW永磁发电机进行电磁设计,获得发电机的主要尺寸参数,其中定子内径为180 mm,铁心长度为90 mm,永磁体宽度为20 mm,永磁体厚度为4.5 mm。采用ANSYS Maxwell软件进行二维建模并分析其空载和负载情况下的磁场分布,通过ANSYS Maxwell和Simplorer联合对其仿真,对其瞬态特性进行分析。在此基础上研制了低转速永磁风力发电机样机,通过对比发电机转速在256～400 r/min时,样机试验与仿真的功率值和效率值,二者的最大误差为4.47%,低于5%,结果表明该低转速永磁发电机设计可行。     

具有不定位势Kirchhoff型Schrödinger-Bopp-Podolsky系统解的存在性

研究Kirchhoff型Schrödinger-Bopp-Podolsky系统,考虑位势函数V不定的情况。此时Schrödinger算子-Δ+V具有有限维负空间。利用Morse理论,得到Kirchhoff型Schrödinger-Bopp-Podolsky系统非平凡解的存在性。     

注浆法应用于局部非饱和黄土地基中的适用性

为了探明注浆法应用于黄土地区某既有高层建筑地基加固产生负面作用的原因,用以指导该建筑物进一步的加固工作。本文依托某建筑物纠偏工程讨论了注浆法在局部非饱和黄土地基中的适用性。现场监测了建筑物的沉降、倾斜以及地基土孔隙水压力指标,结合地质条件以及前期加固方案,分析了注浆后地基土承载力不升反降、建筑物沉降速率增大的原因。结果表明：注浆开始后,建筑物沉降速明显增大,且南侧高于北侧,随着施工的暂停和恢复,沉降速率随之减小和增大。最大沉降速率达2.05 mm·d-1,南北两侧最大沉降差达40.78 mm。孔隙水压力变化趋势与沉降速率类似,最大孔隙水压力达990.21 kPa。停止注浆后,地基南侧各处孔隙水压力有所降低,降幅约8.85%~45.56%。注浆使建筑物产生不均沉降的原因为,未凝结浆液中的水在注浆压力和较高的孔隙水压力作用下逐渐渗透到本就排水条件不良的地基土中,且由于地基内初始孔隙水压力及初始排水条件的差异,对地基产生了不均匀的影响,最终体现在建筑物不均匀沉降上。可见对于类似的排水条件不良且孔隙水压力过大的局部非饱和黄土地基,注浆加固前应采取打入排水板、泄压孔等措施消散孔隙水压力,然后再进行注浆施工。