排序方式: 共有36条查询结果,搜索用时 93 毫秒
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Senderek J Krieger M Stendel C Bergmann C Moser M Breitbach-Faller N Rudnik-Schöneborn S Blaschek A Wolf NI Harting I North K Smith J Muntoni F Brockington M Quijano-Roy S Renault F Herrmann R Hendershot LM Schröder JM Lochmüller H Topaloglu H Voit T Weis J Ebinger F Zerres K 《Nature genetics》2005,37(12):1312-1314
SIL1 (also called BAP) acts as a nucleotide exchange factor for the Hsp70 chaperone BiP (also called GRP78), which is a key regulator of the main functions of the endoplasmic reticulum. We found nine distinct mutations that would disrupt the SIL1 protein in individuals with Marinesco-Sj?gren syndrome, an autosomal recessive cerebellar ataxia complicated by cataracts, developmental delay and myopathy. Identification of SIL1 mutations implicates Marinesco-Sj?gren syndrome as a disease of endoplasmic reticulum dysfunction and suggests a role for this organelle in multisystem disorders. 相似文献
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Astrid v. Lützow 《Cellular and molecular life sciences : CMLS》1966,22(4):215-216
Summary Theb-wave in the electroretinogram of the isolated retina of the rabbit can be completely preserved by addition of plasma to the perfusing fluid. The plasma factor is a non-protein (heat-stable, molecular size <24Å), and was found in the plasma of rabbit, man, and horse. 相似文献
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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins 总被引:3,自引:0,他引:3
Veldhoen M Hirota K Westendorf AM Buer J Dumoutier L Renauld JC Stockinger B 《Nature》2008,453(7191):106-109
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A microglial cell is both a glial cell of the central nervous system and a mononuclear phagocyte, which belongs to the haematopoietic system and is involved in inflammatory and immune responses. As such, microglia face a challenging task. The neurons of the central nervous system cannot divide and be replenished, and therefore need to be protected against pathogens, which is a key role of the immune system, but without collateral damage. In addition, after physical injury, neural cells need restorative support, which is provided by inflammatory responses. Excessive or chronic inflammatory responses can, however, be harmful. How microglia balance these demands, and how their behaviour can be modified to ameliorate disorders of the central nervous system, is becoming clear. 相似文献
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Yayuan Qin Yao Shen Changle Liu Hongliang Wo Yonghao Gao Yu Feng Xiaowen Zhang Gaofeng Ding Yiqing Gu Qisi Wang Shoudong Shen Helen C.Walker Robert Bewley Jianhui Xu Martin Boehm Paul Steffens Seiko Ohira-Kawamura Naoki Murai Astrid Schneidewind Xin Tong Gang Chen Jun Zhao 《科学通报(英文版)》2022,(1):38-44
We report thermodynamic and neutron scattering measurements of the triangular-lattice quantum Ising magnet TmMgGaO4 in longitudinal magnetic fields.Our experime... 相似文献
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H. Bornschein Renate Hanitzsch Astrid V. Lützow 《Cellular and molecular life sciences : CMLS》1966,22(2):98-99
Summary Barbiturates cause an increase of the ERG amplitude in the isolated perfused retina of the rabbit as well as in the eye of the intact animal. Therefore, this effect cannot be transmitted by centrifugal fibres in the optic nerve. 相似文献
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Résumé Les complications de traitement radiothérapique sont moins nombreuses pour les groupes I et II qui ont reçu des alcoxyglycérols que pour le groupe de contrôle III qui n'a été traité que par la radiothérapie. Le nombre de complications a diminué de plus de 50% pour le groupe I qui a reçu les alcoxyglycérols avant, pendant et après le traitement aux rayons. 相似文献
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