New models of collaboration in genome-wide association studies: the Genetic Association Information Network

The Genetic Association Information Network (GAIN) is a public-private partnership established to investigate the genetic basis of common diseases through a series of collaborative genome-wide association studies. GAIN has used new approaches for project selection, data deposition and distribution, collaborative analysis, publication and protection from premature intellectual property claims. These demonstrate a new commitment to shared scientific knowledge that should facilitate rapid advances in understanding the genetics of complex diseases.     

苏北盆地泰州组原油中芴系列的特征与意义

 苏北盆地是中国东部唯一发现的上白垩统自生自储工业油藏的盆地。通过分析上白垩统泰州组20个油砂和1个原油样品芳烃化合物,发现芳烃馏分以三芳甾烷系列为主,指示母质沉积水体咸化和原油低成熟。来源于高等植物的生物标志物丰度低,反映原油母质以腐泥型为主。芳烃各组分相对含量、三芴系列相对含量和比值、二苯并噻吩/菲等参数反映了原油母质总体形成于强还原的咸水环境,不同地区的还原性存在差异。海安凹陷和高邮凹陷北坡的泰州组原油同属一族群,而吴堡低凸起泰州组原油属于另一族群。利用甲基二苯并噻吩比值换算的镜质组反射率（R_o）,推测海安凹陷泰州组原油来源于泰州组未-低熟烃源灶,高邮凹陷北坡的泰州组原油来源于就近泰州组的低熟烃源灶,而吴堡低凸起泰州组原油来源于邻区高邮深凹成熟的阜宁组烃源灶。研究结果对指导油气勘探具有实际意义。     

整合多尺度信息的裂缝性储层建模方法探讨

由于裂缝性储层裂缝分布具有很强的非均质性,且在空间呈现块状分布,常规地质建模方法并不适用于裂缝建模,基于三维地震、测井及岩心裂缝观测,探讨了适合裂缝性储层的建模思路和方法,指出从岩心观测和测井解释上获得小尺度裂缝的参数,包括裂缝密度、几何形态以及其他裂缝属性的统计信息;基于三维地震获取大尺度裂缝的空间分布信息.通过对2...     

A General Theory of Estimation of Variance-Covariance Components

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英语学习纵横谈

英语历史悠久,应用广泛,在国际交流媒介中占有重要的地位;国人学习英语可以更好地为我国的建设服务;要真正学好英语就必须认真学好英语的知识和理论,重视听、说、读、写四种英语技能的培养,了解外国文化,尤其是英美文化。     

江苏省航运量的预测

研究江苏省航运量的预测。利用线性回归模型和提出的灰色绝对残差辨识模型预测了１５个结点的货运量及分货种的出发量和进入量，引用离散相对吸引力及“用户最优分布模型”成功地预测了１９９５，２０００，２０１０年１５×１５个结点对之间的总量及分货种的Ｏ－Ｄ分布，其结果为江苏省航运系统优化规划提供了可靠的依据．     

发展专门用途英语 培养应用型外语人才——地方大学发展专用英语的探讨

地方经济的发展非常需要具有专用英语知识的应用型人材,为地方经济服务是地方性大学的办学宗旨。因此,发展专用英语,不断适应地方对人材需求的变化,培养应用英语人材,不仅是地方经济发展的必然要求,也是专用英语发展的关键,培养一支优秀的教师队伍则是发展专用英语的保证。     

思维美学研究在素质教育中的作用

从思维美学研究的对象和内容出发， 侧重于创造活动和人格完善两个方面， 论述了思维美学研究对于素质教育的作用     

Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells

Hair cells have highly organized bundles of apical projections, or stereocilia, that are deflected by sound and movement. Displacement of stereocilia stretches linkages at the tips of stereocilia that are thought to gate mechanosensory channels. To identify the molecular machinery that mediates mechanotransduction in hair cells, zebrafish mutants were identified with defects in balance and hearing. In sputnik mutants, stereociliary bundles are splayed to various degrees, with individuals displaying reduced or absent mechanotransduction. Here we show that the defects in sputnik mutants are caused by mutations in cadherin 23 (cdh23). Mutations in Cdh23 also cause deafness and vestibular defects in mice and humans, and the protein is present in hair bundles. We show that zebrafish Cdh23 protein is concentrated near the tips of hair bundles, and that tip links are absent in homozygous sputnik(tc317e) larvae. Moreover, tip links are absent in larvae carrying weak alleles of cdh23 that affect mechanotransduction but not hair bundle integrity. We conclude that Cdh23 is an essential tip link component required for hair-cell mechanotransduction.