Preparation and characterization of graphene oxide paper

Free-standing paper-like or foil-like materials are an integral part of our technological society. Their uses include protective layers, chemical filters, components of electrical batteries or supercapacitors, adhesive layers, electronic or optoelectronic components, and molecular storage. Inorganic 'paper-like' materials based on nanoscale components such as exfoliated vermiculite or mica platelets have been intensively studied and commercialized as protective coatings, high-temperature binders, dielectric barriers and gas-impermeable membranes. Carbon-based flexible graphite foils composed of stacked platelets of expanded graphite have long been used in packing and gasketing applications because of their chemical resistivity against most media, superior sealability over a wide temperature range, and impermeability to fluids. The discovery of carbon nanotubes brought about bucky paper, which displays excellent mechanical and electrical properties that make it potentially suitable for fuel cell and structural composite applications. Here we report the preparation and characterization of graphene oxide paper, a free-standing carbon-based membrane material made by flow-directed assembly of individual graphene oxide sheets. This new material outperforms many other paper-like materials in stiffness and strength. Its combination of macroscopic flexibility and stiffness is a result of a unique interlocking-tile arrangement of the nanoscale graphene oxide sheets.     

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca<Superscript>2+</Superscript> signalling

Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce invasivity of CRC. Understanding the mechanisms of metastatic CRC is crucial for successful intervention. Therefore, we studied pro-invasive contributions of stromal cells in physiologically relevant three-dimensional in vitro assays consisting of CRC spheroids, CAFs, extracellular matrix and endothelial cells, as well as in reductionist models. In order to elucidate how CAFs support CRC invasion, tumour spheroid-induced CAF retraction and free intracellular Ca²⁺ levels were measured and pharmacological- or siRNA-based inhibition of selected signalling cascades was performed. CRC spheroids caused the retraction of CAFs, generating entry gates in the adjacent surrogate stroma. The responsible trigger factor 12(S)-HETE provoked a signal, which was transduced by PLC, IP3, free intracellular Ca²⁺, Ca²⁺-calmodulin-kinase-II, RHO/ROCK and MYLK which led to the activation of myosin light chain 2, and subsequent CAF mobility. RHO activity was observed downstream as well as upstream of Ca²⁺ release. Thus, Ca²⁺ signalling served as central signal amplifier. Treatment with the FDA-approved drugs carbamazepine, cinnarizine, nifedipine and bepridil HCl, which reportedly interfere with cellular calcium availability, inhibited CAF-retraction. The elucidation of signalling pathways and identification of approved inhibitory drugs warrant development of intervention strategies targeting tumour–stroma interaction.     

Robust Finite-Time Stability and Stabilization of a Class of Fractional-Order Switched Nonlinear Systems

This paper deals with the problem of finite-time boundedness and finite-time stabilization boundedness of fractional-order switched nonlinear systems with exogenous inputs. By constructing a simple Lyapunov-like function and using some properties of Caputo derivative, the authors obtain some new sufficient conditions for the problem via linear matrix inequalities, which can be efficiently solved by using existing convex algorithms. A constructive geometric is used to design switching laws amongst the subsystems. The obtained results are more general and useful than some existing works, and cover them as special cases, in which only linear fractional-order systems were presented. Numerical examples are provided to demonstrate the effectiveness of the proposed results.     

A Systemic Indicators Framework for Sustainable Rural Community Development

Systemic Practice and Action Research - Community indicators have been of special interest to scholars worldwide, because of their vital role in community development. Nevertheless, the best way to...     

Revealing Community Perceptions for Ecological Restoration Using a Soft System Methodology

Human perceptions under unstructured forms contain valuable information for ecological restoration (ER). To aid in ER, this paper introduces a working process to analyze the unstructured information for the case study of black bear restoration (BBR) in East Texas where understanding of the perceptions of stakeholders at a community level is needed. We identified the current situation, revealed stakeholders and their interactions, and developed actions for change for BBR. Our techniques included recording discussions in meetings, Soft Systems Methodology, and stakeholder analysis. Results indicated the current situation of BBR with human-bear and human-human conflicts. We figured out that information exchange was interrupted in the public, a potential cause for conflicts. Through a systemization, results showed various roles of key stakeholders and constraints for BBR. We found that local state agencies and local residents (particularly landowners) are the key decision-makers for BBR success. Their collaboration can result in a small portion of success (1/9) that can be increased by more cooperation. The SSM framework introduced in this study can be used for modeling community perceptions in ecological restoration.

     

移动平均市场预测的探索

在原有移动平均线的理论基础上,把一天分成四个时间单位,并利用加权公式算出当天收盘价格H取代简单算术移动平均中的收盘价S进行一次移动平均,在此基础上建立了其二次、三次移动平均法的预测模型。