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61.
62.
In 80% of the years between 1975 and 1989 chorus frogs were able to produce offspring that completed metamorphosis and became members of the next generation. During 3 of these 15 years (1975, 1983, and 1986), floods annihilated chorus frogs in the breeding pond. Between 1905 and 1989 this geographically isolated population of Pseudacris regilla , the Pacific chorus frog, located at the western edge of the Great Basin in northwestern Nevada, became reestablished after 10 natural physical disturbances including spring flash floods, numerous kill-offs by sudden drastic rises in water temperature, and stream dry-ups. Ninety percent of the frogs in this population were shades of green with black dorsal speckles and eyestripes. Predators were the belted kingfisher ( Megaceryle alcyon ), western terrestrial garter snake ( Thamnophis elegans ), and domestic house cat ( Felix domestica ). 相似文献
63.
Four species of Dipogon are recorded from Colorado for the first time. These are hurdi Evans, pulchripennis (Cresson), graenicheri Banks, and brevis (Cresson). All are inhabitants of wooded areas and are believed to nest in cavities in trees. Notes are presented on habitat and prey of these 4 species and of the recently described species kiowa Evans. 相似文献
64.
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65.
66.
MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters 总被引:15,自引:0,他引:15
The T-cell immune response is directed against antigenic peptide fragments generated in intracellular compartments, the cytosol or the endocytic system. Peptides derived from cytosolic proteins, usually of biosynthetic origin, are presented efficiently to T-cell receptors by major histocompatibility complex (MHC) class I molecules, with which they assemble, probably in the endoplasmic reticulum (ER). In the absence of recognizable N-terminal signal sequences, such cytosolic peptides must be translocated across the ER membrane by a novel mechanism. Genes apparently involved in the normal assembly and transport of class I molecules may themselves be encoded in the MHC. Here we show that one of these, the rat cim gene, maps to a highly polymorphic part of the MHC class II region encoding two novel members of the family of transmembrane transporters related to multidrug resistance. Other members of this family of transporter proteins are known to be capable of transporting proteins and peptides across membranes independently of the classical secretory pathway. Such molecules are credible candidates for peptide pumps that move fragments of antigenic proteins from the cytosol into the ER. 相似文献
67.
M A Shipp G B Stefano L D'Adamio S N Switzer F D Howard J Sinisterra B Scharrer E L Reinherz 《Nature》1990,347(6291):394-396
The antigen CD10 (common acute lymphoblastic leukaemia antigen), which is the zinc metalloprotease, neutral endopeptidase 24.11 (also known as NEP or 'enkephalinase'), is expressed by acute lymphoblastic leukaemias, normal lymphoid progenitors, mature polymorphonuclear leukocytes and certain nonhaematopoietic cells. CD10/NEP hydrolyses several naturally occurring peptides, including the endogenous opioid pentapeptides Met- and Leu-enkephalin. In invertebrate organisms such as the mollusc Mytilus edulis, Met-enkephalin triggers inflammatory responses by inducing morphological changes, directed migration and aggregation of haemocytes. We report here that a structure related to CD10/NEP is expressed by M. edulis haemocytes and that abrogation of CD10/NEP enzymatic activity reduces the amount of Met-enkephalin required for haemocyte activation by five orders of magnitude. Similar results are obtained with CD10+ human polymorphonuclear leukocytes, indicating that CD10/NEP related structures regulate enkephalin-mediated inflammatory responses in organisms whose ancestors diverged approximately 500 million years ago. 相似文献
68.
This paper explores how the physicist John Tyndall transformed himself from humble surveyor and schoolmaster into an internationally applauded icon of science. Beginning with his appointment as Professor of Natural Philosophy at the Royal Institution in 1853, I show how Tyndall’s worries about his social class and Irish origins, his painstaking attention to his lecturing performance and skilled use of the material and architectural resources of the Royal Institution were vital to his eventual success as a popular expositor and ambassador for science. Secondly I explore the implications of Tyndall’s ‘popularity’ with respect to debates over the meaning and value of scientific ‘popularisation’. In support of recent work challenging diffusionist models of science communication, I show how Tyndall’s interactions with his audiences illustrate the symbiotic relationship between producer and consumer of ‘popular’ science. By examining the views of Tyndall’s critics—notably the ‘North British’ group of physicists—and his defenders and rivals in the domain of popular scientific lecturing, I show that disputes over Tyndall’s authority reflected anxieties about what constituted popular science and the transient boundaries between instruction and entertainment. The term ‘popularisation’ enjoyed many different uses in these debates, not least of all as a rheorical device with which to either exalt or destroy a scientist’s credibility. 相似文献
69.
The in vitro characterization of the inhibition of mouse brain protein kinase-C by retinoids and their receptors 总被引:2,自引:0,他引:2
The mechanism of the in vitro inhibition of Ca2+-, phosphatidylserine-dependent protein kinase C (PK-C)2 by the purified holo (ligand-saturated) forms of cellular retinol-binding protein (cRBP) and cellular retinoic acid-binding protein (cRABP) was studied. We report here that the PK-C-inhibitory action of holo-cRBP and holo-cRABP is due to their respective ligands, all-trans-retinol and all-trans-retinoic acid; the reduced phosphorylation of the holo-retinoid-binding proteins and brain cytosolic proteins is not the result of a retinoid-induced soluble phosphatase or protease activity; retinoids reduce PK-C affinity for calcium and phosphatidylserine in vitro; and the structure-function activity of the retinoids and the specific interaction of these compounds with their binding proteins are important in blocking the activity of PK-C. These observations suggest that the inhibitory effect of retinoids on plasma membrane-associated PK-C activity pays a significant role in defining the early epigenetic aspects of PK-C-dependent tumor promotion and may be a physiological mechanism by which retinoids induce terminal differentiation in cell types that do not express soluble retinoid-binding proteins. 相似文献
70.
Seven-transmembrane-spanning receptors and heart function. 总被引:32,自引:0,他引:32
Understanding precisely how the heart can recognize and respond to many different extracellular signalling molecules, such as neurotransmitters, hormones and growth factors, will aid the identification of new therapeutic targets through which cardiovascular diseases can be combated. In recent years, we have learned more about the complex interactions that occur between the receptors and the signalling pathways of the heart and its environment. Most of these discoveries have focused on the most common type of cardiac receptor - the seven-transmembrane-spanning receptor or G-protein-coupled receptor. 相似文献